SPECT/CT
These are some sample SPECT/CT images from the Small Animal Imaging Resource (UT-SAIR).
![Lung Cancer](/edumedia/eduimages/research/sair/image_gallery/lung-cancer-sm.png)
Lung cancer imaging: SPECT images showing different uptake dynamics of a 99mTc tagged with a DTPA tracer (i.p.) by H2009 vs. H460 tumors.
![Renal Image](/edumedia/eduimages/research/sair/image_gallery/renal.png)
Renal imaging (SPECT/CT) using 99mTc-DMSA: When administered, 99mTc-DMSA intravenously apparently binds to plasma proteins in the blood and collects in the renal cortex. This allows measurement of relative left and right renal (kidney) function and is a very sensitive test to indicate the presence of renal scars or active infection in the kidney (pyelonephritis).
![Renal TC-MAG3](/edumedia/eduimages/research/sair/image_gallery/renal-mag-3.png)
Renal imaging (SPECT/CT) using 99mTc-MAG3: The MAG3 clearance is highly correlated with the effective renal plasma flow (ERPF), and can be used as an independent measure of renal function. After intravenous administration, about 40-50% of the MAG3 in the blood is extracted by the proximal tubules with each pass through the kidneys; the proximal tubules then secrete the MAG3 into the tubular lumen. Note: MAA was also injected.
![SPECT Cardiac Gating](/edumedia/eduimages/research/sair/image_gallery/spect-cardiac-gating.png)
Cardiac gating is used to reduce motion artifacts generated by the pumping heart. ECG signals guide the SPECT acquisition so that the resulting images show the heart as it contracts.
![Respiratory Gating](/edumedia/eduimages/research/sair/image_gallery/respiratory-gating.png)
Respiratory gating: The respiration signals are monitored continuously and are used to guide SPECT acquisition the same way as cardiac gating.