2025 Article Archive
UT Southwestern scientists develop ‘self-driving’ microscope
A new “self-driving” microscope developed by UT Southwestern Medical Center researchers solves two fundamental challenges that have long plagued microscopy: first, imaging living cells or organisms at dramatically different scales, and second, following a specific structure or area of interest over long periods of time. This innovation, detailed in Nature Methods, is already making observations that have not been possible with conventional methods.
Upper urinary tract cancer drug may offer long-term benefits
While randomized comparative trials are needed, a relatively new treatment option for upper urinary tract cancers shows promise for lowering long-term recurrence in many patients with low-grade disease, according to a multicenter study led by researchers at UT Southwestern Medical Center.
Neurostimulation shows promise as potential Alzheimer’s treatment
Repeated sessions of electrical stimulation to brain networks associated with memory improved verbal learning in some Alzheimer’s disease patients for up to eight weeks in a preliminary trial led by UT Southwestern Medical Center researchers. The findings, published in The Journal of Prevention of Alzheimer’s Disease, indicate that while future trials are needed, neurostimulation shows early promise as a treatment for Alzheimer’s and other neurodegenerative disorders, such as Lewy body dementia.
Cryo-EM technology reveals how vitamin K works in the body
Using a powerful microscopy technique, a team led by researchers at UT Southwestern Medical Center has gained insights into how the body uses vitamin K, an essential nutrient that plays a pivotal role in blood clotting and other physiological functions.
UTSW researchers use focused ultrasound to identify stroke biomarkers
A molecule called glial fibrillary acidic protein (GFAP) rose significantly in the blood of patients who underwent high-intensity focused ultrasound (HIFU), a procedure that is used to treat tremors and causes damage similar to a small stroke, UT Southwestern Medical Center scientists discovered in a new study. Their findings, published in Brain Communications, reveal a potential biomarker for stroke and could eventually lead to blood tests that quickly diagnose brain injuries.
Video helps defibrillator patients make informed choices
A UT Southwestern Medical Center quality improvement team led a large-scale, multispecialty project in partnership with the Parkland Center of Innovation and Value to help patients with implantable cardioverter defibrillators (ICDs) better understand their devices and make choices about their care.
New target to thwart multidrug resistance in cancer treatment
Multidrug resistance in cancer can be overcome by combining a drug that blocks a key enzyme with another anticancer drug, according to a study in preclinical models led by researchers at UT Southwestern Medical Center. The findings, published in Science Advances, could have implications for patients with certain cancers that have KRAS-G12C mutations after resistance to drug therapy develops.
Researchers make molecular connection between blindness, dementia
Researchers at UT Southwestern Medical Center have linked blindness in animal models to a brain-wide cellular stress response that’s a common risk factor for dementia. Their findings, published in Nature Communications, could help explain the connection between vision or hearing loss and dementia.
AI chatbots are mostly correct, but incomplete, on endometriosis
Three of the leading chatbots can provide basic information about endometriosis, a painful gynecologic condition that affects as many as 1 in 10 women, but their responses are not as comprehensive as the guidance from health care providers, according to a study by UT Southwestern Medical Center researchers.
Children’s Research Institute at UT Southwestern scientists identify feature of aggressive non-small cell lung cancer
In localized non-small cell lung cancer (NSCLC), a tumor’s ability to use carbon from glucose to feed the tricarboxylic acid (TCA) cycle predicts cancer spread beyond the lung, months to years before metastases are clinically apparent. According to this new research from Children’s Medical Center Research Institute at UT Southwestern (CRI) published in Cancer Discovery, tumors with this metabolic activity result in early patient death.