Grants
Grants provide the funding for our research. Many of our grants come from the National Institute of Health – some of the most difficult grants to be awarded.
Active
1R01 HD097330-01
Yi Hong, Ph.D. (PI)
02/2019 – 01/2026 (NCE)
To develop an injectable bio adhesive made of specialized nanoparticles in the early management of pelvic floor prolapse.
1R01DK131267-01
Nicole De Nisco, B.S., Ph.D. (PI)
09/30/2021 – 04/30/2026
Defining the dynamics of urobiome structure and function in postmenopausal women and its role in recurrent UTI susceptibility.
This grant is actively recruiting women with recurrent urinary tract infections. The control group, namely women who never experienced a Uti, has been fully enrolled. New microbiome data has been submitted as abstracts for the SUFU and EAU/AUA meetings in 2024 and SUFU meeting 2025.
R21 AI169323-01A1
Nicole De Nisco, B.S., Ph.D. (PI)
8/18/2023 - 7/31/2025
Title: “Urovirulence and fimbrial regulation in Klebsiella quasi-pneumoniae.”
This two-year grant with Dr. Greenberg and Dr. De Nisco is aimed at defining the clinical and urovirulence features of a new bacterial species causing recurrent urinary tract infections.
1R 21 DK40688-01
Jeremiah Gassensmith, Ph.D. - UT Dallas
07/2024 – 06/2026
With Nicole De Nisco, Ph.D. and Philippe Zimmern, M.D.
Title: “Targeted ablation of bladder-resident uropathogenic bacteria with a novel cell penetrating dye.”
R 01
Philippe E. Zimmern, M.D.
Title: “Multicentric randomized trial of daily nitrofurantoin versus bladder fulguration plus daily nitrofurantoin for the long-term management of cystitis in women with recurrent urinary tract infections.”
To be started in April 2025
Submitted
R21
Shalini Prasad, Ph.D. (PI) - UT Dallas
Title: “USENSE: an electrochemical biosensor for improved point-of-care urinary tract infection diagnosis.”
Resubmitted October 2024
R 01
Larry Reitzer, Ph.D. - UT Dallas
Title: “Urovirulence of uropathogenic B2 strains.”
Re-Submitted November 2024
R 01
Philippe E. Zimmern, M.D.
Title: “Randomized controlled trial of D-mannose for the prophylaxis of recurrent urinary tract infections in post-menopausal women.”
Submitted October 2024
In Preparation
R 21
Subash Sarguru, Ph.D. - Texas A&M University
Title: “Host-pathogen interaction in the porcine urinary tract.”
To be submitted February 2025
R 01
Taylor H. Ware, Ph.D. - Texas A&M University
(February 2024)
Title: “Shape-changing Midurethral sling for Stress urinary incontinence.”
To be submitted February 2025
R 21
Nicole De Nisco, B.S., Ph.D. – UT Dallas
Title: “Elimination of bladder bacterial reservoirs with intravesical VesiX CPC solution.”
To be re-submitted March 2025
Randomized Controlled Trials and Prospective Studies at the Cain Bladder Center
RCT (October 2024)
Philippe Zimmern, M.D. (PI)
Title: “A multicenter randomized non-inferiority trial of empiric versus culture-based antibiotic therapy for UTIs in adult women with a history of recurrent UTIs.”
RCT (February 2025)
Philippe Zimmern, M.D. (PI)
Title: “Randomized controlled trial of D-mannose for the prophylaxis of recurrent urinary tract infections in post-menopausal women.”
RCT (April 2025)
Philippe Zimmern, M.D. (PI)
Title: “Randomized double blind clinical trial of methenamime hippurate versus nitrofurantoin for the prophylaxis of recurrent urinary tract infections in postmenopausal women.”
Prospective study
Philippe E. Zimmern, M.D. and Nicole De Nisco, B.S., Ph.D. (PI) UT Dallas
Title: “The impact of estrogen hormone therapy modality on urobiome dynamics in postmenopausal women.”
Completed
R21 EB028547-01
Taylor H. Ware, Ph.D. (PI)
08/01/2019 – 04/30/2022
Liquid Crystal Elastomer as a Dynamic Treatment of Incontinence
This grant received an extension until 2023. The data from this grant has been used to submit an R 01 grant in October 2024.
R01 DK120307-01
Mario Romero-Ortega, Ph.D. (PI)
07/06/2018 – 07/06/2023
Pelvic floor musculature in the aged and multiparous rabbit model as surrogate for the management of urinary incontinence and pelvic floor dysfunction in women.
This grant received an extension until 2024.
CTSA Pilot Award Grant at UT Southwestern 1UL1TR003163-01A1
Subash Sarguru, Ph.D. (Co-PI)
5/25/2022 – 05/24/2023
A miniature pigmodel of urinary tract infection
UT Dallas CoBRA Grant (No grant number)
Larry Reitzer, Ph.D. (PI)
07/01/2019 – 06/30/2021
Urinary tract infections and uropathogenic bacteria
2UG1HD054241-11
Ike Rahn, M.D. (PI)
07/01/2016 – 07/01/2021
To develop and implement pelvic floor related projects with the PFDN
5R01DK120307-04
Mario Romero-Ortega, Ph.D. (PI)
08/01/2021 – 07/31/2023
Neuromodulation of Individual Pelvic Floor Muscle Activity in Urinary Incontinence