Neuroscience Program Faculty

Research Interests: Epigenetics, neurological disorders, genome engineering, single-cell genomics

Research Interests: Engineering adeno-associated viral (AAV) vectors; Developing viral-mediated gene therapies for pediatric neurological disorders; developing gene therapies for Alzheimer’s and neurogenerative diseases; selective targeting of AAV vectors to the central and peripheral nervous systems; facilitating the translation of gene therapies to use in clinical trials

Research Interests: Biomedical engineering, Brain and spinal cord monitoring, Cerebral metabolism and hemodynamics, Diffuse correlation spectroscopy (DCS), Diffuse optical spectroscopy (DOS), Intraoperative neuromonitoring, Medical device development, Near-infrared spectroscopy (NIRS), Non-invasive monitoring, Spinal cord hemodynamics

Research Interests: Biomarkers, Biotargets, Vascular Dysfunction, Organ Dysfunction, Inflammatory Disorders, Endothelial Function, Neurodegenerative Diseases, Translational Research.

Research Interests: Somatosensation, pain and touch pathways, mouse genetics, in vitro and in vivo physiology, optogenetics

Research Interests: Cognitive neuroscience; language; cognition; social communication; fMRI; neuroimaging; autism spectrum disorders; development; cerebellum

Research Interests: Motor function, dystonia, Parkinson’s disease, neural circuits, neurodegeneration

Research Interests: Mechanisms of amyloid propagation in neurodegenerative diseases, especially tauopathies (e.g. Alzheimer’s disease), synucleinopathies (e.g. Parkinson’s disease), and polyglutamine diseases (e.g. Huntington’s disease); linkage between amyloid structure and biological impact

Research Interests: Aging and stress response signaling in traumatic brain injury and neurodegeneration

Research Interests: Functional neuroanatomy of the mammalian hypothalamus

Research Interests: Behavioral neuroscience, microbiome, neuroimmunology, psychiatry, biomarkers, bioinformatics, animal models of disease, mental health

Research Interests: Ataxia, Cerebellar anatomy, Cerebellar development

Research Interests: Alzheimer’s disease, Parkinson’s disease, autism

Research Interests: Molecular mechanisms of circadian rhythms and how they control metabolism

Research Interests: Circuit dysfunction in psychiatric disorders; role of adenosine in function of sleep

Research Interests: Dissection of neural mechanisms that support integration of sensory information, memory, and internal state to guide behavior using a multidisciplinary approach that encompasses molecular genetics, neural recording, optogenetics, behavioral experiments, and computational modeling.

Research Interests: Cell migration, survival, stress response, cancer

Research Interests: Function and regulation of membrane transporters; electrophysiology; biophysics of ion pumps and channels

Research Interests:Treatment Resistant Depression, Animal Models, Lateral Habenula, Systems Neuroscience

Research Interests: Mechanisms of synapse development, plasticity and circuit function, and alterations of these processes in mouse models of intellectual disability and autism

Research Interests: Molecular control of neuronal diversity and balancing progenitor cell maintenance with neuronal differentiation in the vertebrate central nervous system implications for tumor progression in neural and neuroendocrine cancers

Research Interests: Neural circuit genetics, neural representation and memory engrams for learning and memory in entorhinal-hippocampal circuits of rodent brain under normal and psychotic conditions by applying in vivo calcium imaging, in vivo electrophysiology, viral-tracing and circuit manipulation

Research Interests: Neurodevelopmental signaling pathways involved in cognition and neuropsychiatric disorders; comparative gene expression for insight into human brain evolution

Research Interests: Genetic dissection of endocytic trafficking in Drosophila

Research Interests: Connectivity and development of neuronal circuits generating somatosensation; molecular and functional diversity of spinal cord interneurons

Research Interests: Memory encoding and retrieval; Restoring memory function after brain injury

Research Interests: Neuroimaging, MRI, dynamic brain connectivity, dopamine, astrocytes, reward and learning, neurovascular coupling

Research Interests: Learning and Memory; Neurodevelopmental Disorders; Neuronal Activity-dependent Gene Transcription; Experience-dependent Synaptic Modification; Neural Circuits; GABAergic Inhibitory Circuits; E/I Balance; Memory Discrimination and Generalization

Research Interests: Developmental neurobiology, cellular and molecular basis of synapse formation, function, maintenance, and degeneration, using approaches including electrophysiology, genetics, and molecular biology.

Research Interests: Cellular and functional diversity in the hypothalamus; 5-HT circuits underlying energy and glucose homeostasis; Fetal programming of obesity and diabetes

Research Interests: Chromatin dynamics and epigenetic regulation of activity-dependent gene expression; the role of genomic instability in neurological disorders and cancer

Research Interests: Understanding the molecular basis of glycogen malformation in the fatal Lafora epilepsy and devising gene and small-molecule based therapies for this and other childhood neurogenetic disorders

Research Interests: Friedreich’s ataxia, chromatin and transcription regulation, repeat sequence instability, gene editing, mitochondrial dysfunction, induced pluripotent stem cell models of neurodegeneration, cerebellar function and degeneration

Research Interests: Regulatory mechanisms impacting structure, function and location of glycogen; Molecular consequences of glycogen storage diseases; Development of treatment strategies on molecular basis of the disease pathogenesis; Engineering proteins for improved Gene Therapy

Research Interests: Neuro-immune interactions, intestinal neural circuits, host-microbial interactions, gut-brain axis and circadian clock

Research Interests: Neuroprotection, CNS injury, neurodegenerative diseases, axon regeneration, CNS circuits

Research Interests: Consolidation and recall of memory via large-scale, high-density in vivo recordings of neural activity during free behavior in rodents, focusing on spatial navigation as a specific example of more general memory formation and use

Research Interests: Neural Circuits for Basic Biological Motivations, Pain, Pain Relief, Cell-type Targeted Gene Therapies

Research Interests: Analyses of intracranial human neurophsyiology to investigate basic human neuroscientific principles of motor control, the pathophysiology of disease, and to develop novel stimulation-based therapeutics for human neuropsychiatric disease, including depression, OCD, and consciousness.

Research Interests: FMRP, Fragile X, auditory development, hearing loss

Research Interests: Reward circuit function in animal models of depression and addiction

Research Interests: Cerebellar ataxia, SCA, ion channels, neurodegeneration, selective neuronal vulnerability, potassium channels, Purkinje neurons

Research Interests: Alzheimer's Disease, tauopathies, cellular tau uptake, neuroinflammatory mechanisms and role of the innate immune system in neurodegeneration

Research Interests: Neuron-glia interaction, oligodendrocyte, myelination, neurological disorders

Research Interests: Mechanistic studies of volume sensors and mechanosensors, ion channel structure-function and related channelopathies

Research Interests: Molecular and genetic analysis of the mammalian circadian clock system

Research Interests: Schizophrenia; postmortem brain; human brain imaging; human translational neuroscience

Research Interests: Axon growth and guidance; neuronal connectivity; axon regeneration; actin cytoskeleton; spinal cord injury and degeneration

Research Interests: Molecular and cellular mechanisms underlying the formation of neuronal circuits responsible for cognition and behavior

Research Interests: CNS injury and diseases, axon regeneration, neural circuit connectivity, vision restoration, neuron-glia interaction

Research Interests: Elucidating the molecular, synaptic, and circuit mechanisms underlying memory persistence

Research Interests: Diffusion MRI; QSM; Neuroimaging; ML/AI; Alzheimer's Disease; Osteoarthritis

Research Interests: Mitochondrial dysfunction, neurodegeneration and PARP-1-dependent cell death (PARthanatos) in Alzheimer’s disease, stroke and traumatic brain injury

Research Interests: Movement Disorders, dystonia, motor control, dopamine, striatum, human development, MRI, diffusion imaging, deep brain stimulation

Research Interests: Tumor suppressor genes (TSG), TSG syndromes, neurofibromatosis type 1, RAS, MEK/ERK, MAPK, p53, developing and adult neural stem cells, neural-crest stem cells, pediatric and adult brain tumors, brain development and evolution, autism spectrum disorder(ASD), neurodevelopmental and neuropsychiatric diseases

Research Interests: Computational Neuroscience

Research Interests: Electrophysiology, neuronal circuits in neocortex, and neuroscience

Research Interests: Friedreich’s ataxia, chromatin and transcription regulation, repeat sequence instability, gene editing, mitochondrial dysfunction, induced pluripotent stem cell models of neurodegeneration, cerebellar function and degeneration

Research Interests: Dietary and nutritional targeting of glioma, mouse models of brain tumors, mitochondrial and anti-oxidant metabolism, redox and growth factor signaling

Research Interests: Locally produced estradiol has been demonstrated to be important for the regulation of synaptic plasticity in the hippocampus. However, very little is known about the factors that regulate the expression of aromatase, the enzyme that converts testosterone into estradiol, in the brain. Our lab uses cell culture techniques and molecular approaches to learn more about the regulation of aromatase expression in the hippocampus of rats and mice.

Research Interests: Magnetoencephalography (MEG), neural oscillations, aging, cognition, cognitive impairment, magnetic resonance imaging (MRI)

Research Interests: 3D reconstruction; Connectomics, Digital Pathology, Histology, Image Analysis, Neuroscience, Serial Two-Photon Tomography, Stroke, Volumetric Imaging

Research Interests: Circadian Physiology; Feeding and Light Entrainment of the Circadian System; Live Cell/Tissue Real-Time Imaging; Mouse Models for Human Disorders Caused by Disruption/Disorganization/Misalignment of the Circadian System; Neural Circuit Controlling Feeding and Locomotor Activity Rhythms; Pacemaker Coupling