Curriculum

The track’s course work and activities will supplement those of the student’s home program. By the end of training, students will be able to:

• Perform original, basic science research on the hormonal, neuronal, and biochemical processes underlying normal metabolism and the metabolic derangements that lead to and result from disease states
• Employ cutting-edge, state-of-the-art techniques in their research projects
• Conduct critical assessments of metabolism-focused scientific literature and apply the latest findings to their own research
• Convey their research findings and the implications of their research findings to the academic community in the form of poster and oral presentations at local, national, and international settings and in the form of peer-reviewed scientific manuscripts

Course Descriptions

Metabolism Masterclass

• This seminar series will provide an intimate setting for students to interact with the many exceptional principal investigators on campus performing metabolism research.
• The lecturer of the day will lead a discussion focusing on a key paper from her/his career, during which the lecturer will reflect on the scientific process, context, and background for the study, while also reviewing the techniques used, results, and conclusions.

• Speakers in this seminar series during 2020-2021 included: Drs. Mike Brown, Helen Hobbs, Joe Takahashi, Joel Elmquist, Philipp Scherer, Lora Hooper, Steven Kliewer, and Ralph DeBerardinis.

• Speakers in this seminar series during 2021-2022 included: Drs. David Mangelsdorf, Jay Horton, Philip Shaul, Ezra Burstein, Russell Debose-Boyd, Ildiko Lingvay, and Melanie Cobb.

• Speakers in this seminar series during 2022-2023 included: Drs. Joe Goldstein, Sarah Huen, Yuh Min Chook, Josh Mendell, Lee Kraus, Kim Orth, Joachim Herz, and Nan Yan.

Manifestations and Pathogenesis of Metabolic Diseases

• Each session of this course will be devoted to a metabolic disease, with the first half of the session focused on the clinical description of the disease ("Manifestations") and the second half of the session focused on the biological mechanisms that cause the disease ("Pathogenesis")
• Both clinician-scientists and basic science researchers will serve as lecturers.
• There will be one speaker who provides the Manifestations description (45 min) and a second speaker who provides the Pathogenesis description (45 min).  Thus, each pair of speakers will collectively devote 1.5 hours of their time in front of the students.
• There will be very short quizzes after each class to reinforce some of the major take-home messages (with questions to be provided by the Speakers)
• No homework. No mandatory papers to read or write. No student presentations.
• The classes will be taught live.
• Topics (lecturers) featured in Summer 2022 included Diabetes Mellitus (Ali, Bickel), Obesity (Almandoz, Williams), Genetic Forms of Obesity and Eating Disorders (Zigman, Elmquist), Lipodystrophy (Garg, Patni), Fatty Liver Disease (Kerr, Burgess), Dyslipidemia (Ahmad, Debose-Boyd), Obesity as a Risk Factor for Cancer (Huang, Scherer), and Cancer Cachexia (Iyengar, Infante).
• Topics (lecturers) featured in Summer 2023 included Hypertension (Nesbitt, Vongpatanasin), Obesity (Vinton, YJ You), Coronary Artery Disease (Joshi, Shaul), Acute Kidney Injury (Huen, Parikh), Osteoporosis (Maalouf, Towler), Epilepsy (Sirsi, Minassian), Inflammatory Bowel Disease (Fudman, Turer), and Type 1 Diabetes (Raskin, Pham).

Metabolism Mayhem Journal Club (Summer 2024)

• This journal club was conceived at the request of the current 3MD students and is designed to give students an opportunity to read/review/discuss some key papers in metabolism, some of which were authored by UT Southwestern faculty. There will be a faculty moderator present throughout the course (Dr. Teppei Fujikawa), however, the journal club discussions will be student led. The journal club will be held over eight one-hour sessions during the Summer 2024.

Introduction to the UT Southwestern Core Facilities Workshop (To Be Announced)

• This workshop will enable students to gain familiarity with the platforms and techniques offered through the UT Southwestern Core Facilities related to metabolism.
• The workshop will be designed such that the participants can visit the sites where the cores are housed to learn about the available platforms and techniques, to observe first-hand the machinery and techniques in use, and to interact with the core directors and staff.
• Participants will also get instructions from the core staff regarding considerations for study design and practical aspects of analyzing the data produced by the cores.
• As examples, the participants will observe the staff performing a hyperinsulinemic-hypoglycemic clamp, and the participants will observe our TSE metabolic chamber setup and will receive practical guidance regarding how best to analyze the voluminous sets of locomotor activity, food intake, and indirect calorimetry data.
• This workshop will be staffed by the personnel of the cores who carry out and direct the studies.