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Research Collaborations

Diabetic Limb Salvage Fellowship conducts diverse research on wound management and treatment, with a focus on complex cases such as diabetic foot ulcers and pressure ulcers.

Our research involves innovative techniques and therapies, including:

  • Negative pressure wound therapy with supplemental O2
  • Utilizing biotherapies
  • Evaluation of current and novel treatments for patients with foot ulcerations

We also explore various interventions, such as pressure alternating shoes and medical socks for diabetic foot wounds.

Our studies encompass both clinical outcomes and scientific insights, addressing factors like infection progression, immune responses, and inflammatory biomarkers.

We collaborate with industry partners and institutions to advance wound care strategies and enhance patient outcomes.

Our Projects

The impact of GLP-1 agonists on patients with foot ulcerations

A collaboration with Yucel Akgul, Ph.D. to evaluate the impact of GLP-1 agonists on the healing and outcomes of patients with foot ulcerations. This is in process for NIH grant applications.

Osteomyelitis

 Dr. Andrew Crisologo’s research comprises several studies focused on various aspects of diabetic foot complications, particularly osteomyelitis and diabetic foot ulcers (DFUs).

The project includes the following key investigations:

  • Osteomyelitis: evaluating Spect-CT and bone biopsy (American diabetes association)
  • Multi-center, prospective, randomized controlled trial evaluating Skinte® in the treatment of Wagner 2 DFUS - closure obtained with vascularized epithelial regeneration for DFUS with Skinte® (cover DFUS) (Polarity, Inc.)
  • A randomized, open-label, controlled, phase 2 study to assess safety, tolerability, and efficacy of adjunctive treatment with topically applied MBN 101 in hospitalized patients with moderate to severe diabetic foot infection (DFI) (Microbion corp.)
  • A registry study for subjects who participated in ambulate DFU and ambulate DFU ii (Tissuetech, Inc.)

Biotherapy

Dr. Paul Kim, and Dr. Andrew Crisologo’s research project focuses on the evaluation of innovative biotherapies for the treatment of complex diabetic foot ulcers (DFUs).

A multicenter phase 3 confirmatory trial of biotherapy using cryopreserved human umbilical cord (ttax01) for late-stage, complex non-healing diabetic foot ulcers (ambulate DFU ii) (Tissuetech, Inc. )

Bacterial Activity

Dr. Paul Kim, Dr. Andrew Crisologo, and Dr. Kathryn Davis' study evaluates bacterial activity that drives the progression of clinical infection (AstraZeneca pharmaceuticals lP).

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