Matthew Segar, M.D., PGY1
Seldin Scholar, 2019 & 2020
What stood out about your research experience at UT Southwestern, and how did it shape your career?
I was really impressed with the mentorship. I wouldn’t have had the success or opportunities I’ve had in research without the mentorship of Dr. Ambarish Pandey. He’s been formative in my career in helping teach me the research process, treating me as a colleague, and valuing my opinion.
How did participating in the Seldin Symposium impact your research path?
The Seldin Symposium gave me confidence to know the work I was doing was meaningful and impactful. Some of the work I presented as a resident has made its way into clinical guidelines documents and is still being referenced nearly six years later. The Seldin Symposium was one of the first opportunities I had to present my research on a large scale. It’s initially intimidating presenting at Grand Rounds in front of esteemed faculty and future Nobel laureates, but everyone treated trainees with respect, asked insightful and poignant questions, and really made me feel like the work I was doing mattered.
What are your current research interests and goals?
Currently I’m still researching ways to apply big data techniques to predict future risk of cardiovascular disease and identify novel therapies. Much of my work still involves heart failure, but I’m applying many of those techniques to electrophysiology.
What advice would you offer current Internal Medicine trainees about pursuing research?
Find a good mentor—someone who can give you specific tasks to work on and can find projects that fit your clinical interest.
Representative Publications
- Electronic Health Record Alert With Heart Failure Risk and Sodium Glucose Cotransporter 2 Inhibitor Prescriptions in Diabetes: A Randomized Clinical Trial.
Segar MW, Patel KV, Keshvani N, Kannan V, Willett D, Klonoff DC, Pandey A. J Diabetes Sci Technol. 2024 Sep 10. - Development and Validation of a Machine Learning-based Approach to Identify High-risk Diabetic Cardiomyopathy Phenotype.
Segar MW, Usman MS, Patel KV, Khan MS, Butler J, Manjunath L, Lam CSP, Verma S, Willett D, Kao D, Januzzi JL, Pandey A. Eur J Heart Fail. 2024 Oct. Epub 2024 Sep 6. - An Exercise Enigma: Unravelling the Complexity of Exercise Intolerance in Heart Failure with Preserved Ejection Fraction.
Segar MW, Nair A, Pandey A. Eur J Heart Fail. 2024 Mar. Epub 2024 Feb 27. - Understanding the Language of the Heart: The Promise of Natural Language Processing to Diagnose Heart Failure with Preserved Ejection Fraction.
Segar MW, Pandey A. Eur J Heart Fail. 2024 Feb. - A Phenomapping Tool and Clinical Score to Identify Low Diuretic Efficiency in Acute Decompensated Heart Failure.
Segar MW, Khan MS, Patel KV, Butler J, Ravichandran AK, Walsh MN, Willett D, Fonarow GC, Drazner MH, Mentz RJ, Hall J, Farr MA, Hedayati SS, Yancy C, Allen LA, Tang WHW, Pandey A. JACC Heart Fail. 2024 Mar. - Frailty Status Modifies the Efficacy of ICD Therapy for Primary Prevention Among Patients With HF.
Segar MW, Keshvani N, Singh S, Patel L, Parsa S, Betts T, Reeves GR, Mentz RJ, Forman DE, Razavi M, Saeed M, Kitzman DW, Pandey A. JACC Heart Fail. 2024 Apr. - Race, Social Determinants of Health, and Length of Stay Among Hospitalized Patients With Heart Failure: An Analysis From the Get With The Guidelines-Heart Failure Registry.
Segar MW, Keshvani N, Rao S, Fonarow GC, Das SR, Pandey A. Circ Heart Fail. 2022 Nov. - Machine Learning-Based Models Incorporating Social Determinants of Health vs Traditional Models for Predicting In-Hospital Mortality in Patients With Heart Failure.
Segar MW, Hall JL, Jhund PS, Powell-Wiley TM, Morris AA, Kao D, Fonarow GC, Hernandez R, Ibrahim NE, Rutan C, Navar AM, Stevens LM, Pandey A. JAMA Cardiol. 2022 Aug 1. - Mediators of Ertugliflozin Effects on Heart Failure and Kidney Outcomes Among Patients with Type 2 Diabetes Mellitus.
Segar MW, Kolkailah AA, Frederich R, Pong A, Cannon CP, Cosentino F, Dagogo-Jack S, McGuire DK, Pratley RE, Liu CC, Maldonado M, Liu J, Cater NB, Pandey A, Cherney DZI. Diabetes Obes Metab. 2022 Sep.