Patient-Oriented Research

Research Interests: Diagnosis, prevention, and treatment of chronic kidney disease (CKD) and its related conditions, including peripheral artery disease, vascular calcification, mineral bone disorders, inflammation,  Cardiovascular-Kidney-Metabolic syndrome, and biological aging.

Research Interests: Dr. Lederer has two major clinical research interests.  She is using mathematical modeling and artificial intelligence to study the clinical syndrome of chronic kidney disease mineral bone disorder, a syndrome is associated with the development of fractures, heart failure, and vascular damage, resulting in an accelerated mortality in these individuals.  The goal of this project is to identify early mediators of the syndrome and to develop personalized therapy for individuals with chronic kidney disease.
The second project is to explore the relationships between kidney and bone handling of citrate in the development of bone disease and kidney stones. The goal of this project is to identify determinants of urine citrate in the interest of improving the treatment of osteoporosis and kidney stones.

Pak Center for Mineral Metabolism
Research Interests: Uric acid stones, role of insulin resistance, post-renal transplantation, phosphorus wasting, effect of combined calcium citrate and potassium citrate on the risk of kidney stone and prevention of bone loss

Research Interests: Progression of CKD, lipid disorders, angiotensin II, and dialysis

Research Interests: Mechanisms and management of hypertension in chronic kidney disease and hemodialysis patients, fluid management in hemodialysis patients, diabetic nephropathy