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The Histo Pathology Core is a fully-staffed service center offering research histology and anatomic pathology on a fee-for-service basis.

The lab is directed by Pathologist Bret Evers M.D., Ph.D., managed by John Shelton, a veteran molecular histologist, and is staffed with full-time research technicians and assistants. The lab continues to collaborate with Veterinary Pathologist and Professor Emeritus James Richardson, D.V.M., Ph.D.

UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, Texas 75390-8573

Phone: 214-648-1451
Fax: 214-648-1450

john.shelton@utsouthwestern.edu

Bret M. Evers, M.D., Ph.D., is Pathologist and Director of the Histo Pathology Core. He is Assistant Professor of Pathology, Boarded in Neuropathology as well as Anatomic Pathology, and current faculty member in Neuropathology.

In addition to his Neuropathology responsibilities and Director role for the Histo Pathology Core, Dr. Evers serves as:

  • Integrated Curriculum Course Director, Mechanisms of Disease and Translational Science Human Pathology Course
  • Ad hoc reviewer for the Journal of Alzheimer's Disease
  • Ad hoc reviewer for the Journal of Neuropathology & Experimental Neurology
  • Ad hoc reviewer for the Ophthalmology

Research Interests

Neurodegeneration, neuromuscular disease, ophthalmic pathology, lipid metabolism, lysosomal biology, and inborn errors of development and metabolism.

Research Summary

  • Insig-mediated regulation of craniofacial and hair follicle development
  • Defining the physiologic role of progranulin in lysosomes using lipidomic and transcriptomic approaches

Awards

  • Texas Society of Pathologists: Educational Foundation Scholarship 2015
  • Carl B. and Florence E. King Foundation: Endowed Fund in Alzheimer's Disease Research Award 2015
  • UTSW Department of Pathology: Bruce D. Fallis Resident Award for Teaching 2014 & 2015
  • UT Southwestern Medical School: Outstanding Teacher Award 2017

Education

Ph.D. — UT Southwestern Graduate School, Dallas, TX

M.D. — UT Southwestern Medical School, Dallas, TX

Undergraduate — Texas A&M University, College Station, TX

James A. Richardson, D.V.M., Ph.D., Diplomate (ACVP), is Senior Pathologist and Collaborator of the Histo Pathology Core. Dr. Richardson is Professor Emeritus of Pathology and Molecular Biology, holder of the Minnie Stevens Piper Professorship, and Distinguished Teaching Professor.

In addition to his past teaching responsibilities and directorship of the Histo Pathology Core, Dr. Richardson served as:

  • Course Director, MSII Pathology Course
  • Subcommittee Chair, UT Southwestern Pre-Matriculation Basic Science Curriculum Advisory Committee
  • Chairman, UT Southwestern Student Assistance Committee
  • Member, UT Southwestern Medical School Admissions Committee
  • Vice-Chairman, State of Texas Joint Admissions Medical Program
  • Charter Member, Southwestern Academy of Teachers
  • Member, UT Academy of Health Science Education

Research Interests

gfpemb Characterization of mutant phenotypes and the molecular basis of embryonic and neonatal development, as well as the study of models of heart disease and muscular disorders; utilizing gross pathology, routine histology, in-situ hybridization, and immunohistochemistry techniques. Clinical and research expertise in gross pathology/necropsy, histopathology, specialized microscopy, digital and 35mm imaging and analysis, desktop publishing and graphics.

Research Summary

  • Characterization of the gene knockout phenotypes: Orexin, Insig-1, Capsulin, MyoR, CRP 1/2, Scleraxis, HRT-1/2/3, FBP-1, Nkx2.5, HSF-1/2, EVEC, Enothelins-a, b, 1, 2, 3, ECE-1/2, miRs-143/145, HDAC-1/2/3, dHand, eHand, Ets71, GATA-4/5
  • Characterization of cholesterol synthesis pathway genes: SCALD, LDLR, VLDLR, ApoER2
  • Characterization of the expression patterns of muscle specific genes: Myoglobin, FHL2, MNF, PKD1, MEF2c
  • Characterization of the expression patterns of renal ischemia response genes: IRF-1, IL-6, G-CSF
  • Characterization of cardiac hypertrophy phenotypes as a function of pressure overload or gene expression: CamKII, MLCK, PKD1, MEF2d, HDAC-1/2, STARS, SRF1, TRPC6
  • Models of insulin resistance, glucose homeostasis, and adipose filling: STAT3, SREBP-1c, ET-1
  • Efficacy of skin rejuvenation techniques and skin-filler/lypolysis agents: 1540nmEr laser, CO2 laser, hyaluronic acid
  • Characterization of genetic point mutations resulting in myopathy: H6PD, MEF2c, RING-fp1/3
  • Characterization of smooth muscle homeostasis genes: CRP-1/2, Fibulin-5, Dlx6, Tie-2

Awards

  • University of Texas Regents' Outstanding Teacher Award 2012
  • University of Texas System Distinguished Teacher 2011
  • Outstanding Teacher Award (UT Southwestern): Classes of 2016, 2015, 2014, 2013, 2012, 2011, 2009, 2005, 2003, 2001, 2000, 1998, 1997,1995, 1993, 1991
  • Teacher of the Year (University of Florida): Classes of 1985, 1984

Education

Ph.D. — Purdue University, West Lafayette, IN

D.V.M. — University of Guelph, Guelph, Ontario, Canada

Undergraduate — Trent University, Peterborough, Ontario, Canada

John M. Shelton is Operations Manager of the Histo Pathology Core. Shelton, a veteran molecular histologist, handles all technical and business functions of the lab.

Research Interests

Comparative anatomic and histologic elucidation of mutant and disease phenotypes, the study of skeletal muscle fiber-type remodeling, as well as structural and physiologic based myopathies. Research expertise in gross pathology, routine histology, enzyme histochemistry, in-situ hybridization, immunohistochemistry, laser capture microdissection, digital imaging, morphometrics, plant pathology, and mammalian clinical pathology.

Support and augmentation of long standing research collaborations with the Departments of Pathology, Molecular Biology, Biochemistry, Pharmacology, Internal Medicine - Divisions of Cardiology, Nephrology, Touchstone Diabetes Center, as well as the Howard Hughes Medical Institute:

  • cardiac & skeletal muscle development
  • skeletal muscle physiology - cholesterol metabolism
  • cell signaling and transcription licensing
  • cardiac, renal, and hepatic fibrosis
  • ischemic and acidotic nephropathy
  • tumor prophylaxis and mitigation
  • bile acid metabolism
  • gonadal development
  • cell storage disorders
  • atherosclerosis and vascular weakening

Extramural Studies - Short Courses

  • Buehler Industries Material Science & Processing Wet Lab - Lake Bluff, IL
  • Intl Laser Microdissection & Microgenomics Workshop - Chicago, IL
  • Leica AS-LMD Workshop I & II - New York, NY, Research Triangle, NC
  • Non-Human Primate Precaution Class - San Antonio, TX
  • Texas Society for Microbiology Enterobacteriaceae Course - Temple, TX
  • Texas Electron Microscopy Wet Lab - Houston, TX

Offices & Awards

  • Liaison, UT Southwestern Office of Safety & Business Continuity/Cardiology Division
  • Committee Member - Donald W. Seldin Outstanding Service Award
  • Recipient, Donald W. Seldin Award
  • Recipient, TBAALAS Technical Presenter Award
  • Past Chair, TBAALAS Elections Committee
  • Subject, AP Wire "Biotech doesn't always require advanced degree"
  • Invited Speaker, Baylor Research Foundation Continuing Education

Education

College — Texas A&M University, College Station, Texas

The Histo Pathology Core is staffed with ten full-time technicians who are experienced with research-histology. All full-time lab members are highly capable, degreed professionals, and each is tasked with producing the highest quality histologic sections available from the specimens submitted. Each member is also specialized to serve as point histologist for one, or more, difficult developmental- or investigator-specific anatomies/stains.

In order of most seniority, the technicians are:

Jessica Williams
Senior Research Associate
University of Houston
May 2011 - Present

Juan Alejandro (Alex) Daniel
Research Associate
University of Texas at Arlington
January 2016 - Present

Josue Ramirez
Research Assistant II
Texas A & M University
April 2020 - Present

Olivia Jones
Histology Technician
University of North Texas
September 2020 - Present

 

 

Vanesa Duran
Research Assistant I
Texas Woman's University
May 2021 - Present

Casey Landefeld
Research Technician II
University of Texas
August 2021 - Present

Alejandro Gallegos
Research Technician II
Texas Women's University
November 2022 - Present

Wilson Peltier
Research Technician II
Texas A&M University
December 2022 - Present

Christian Lopez
Research Technician II
University of Texas
February 2023 - Present

Over the long history of the Core, there have been many conscientious technicians and assistants who have contributed to the lab's success.

Their names, exiting title, alma maters, dates of service, and organization that they matriculated to, are listed in tribute to them:

Diana Wigginton
Research Assistant II
Texas A&M University
December '17 – January '23
Payroll Administrator - First Command Financial

Annie Thach
Research Technician II
University of Texas at Arlington
July '21 - October '22

Lindsay Covington
Research Assistant I
University of South Carolina
November '18 – September '22
Master's Student - University of Glasgow

Cameron Perry
Research Associate
University of Texas at Dallas
August '11 - August '22

Mariafernanda Felipa Lastarria
Research Technician II
University of Texas
January '19 – August '21
Health Administration Master's Student – University of North Texas Health Science Center

Jenna White
Research Technician II
Baylor University
March '19 - July '21
Public Health Master's Student – Rutgers University

Jameon Love
Research Technician II
Texas A&M University
June '18 – May '21
Medical Master's Student – University of North Texas Health Science Center

Charles Huff
Research Technician II
University of North Texas
July '18 – July '20
Master's Student - University of Texas at Dallas Jindal School of Management

Anne (Starling) Carter
Research Assistant I
Texas A & M University
June '16 – September '18
Research Study Coordinator - Ophthalmology

Samantha Lopez
Research Technician II
Baylor University
August '17 – June '18
Medical Student - UT Southwestern Medical School

John Hintz
Research Technician II
University of Oklahoma
June '17 – May '18
Medical Student - University of Texas School of Medicine San Antonio

Kevin White
Research Assistant II
Texas A&M University
May '12 – Nov '17
Account Representative - Stericycle Incorporated

Ryan Jones
Research Technician II
Texas A&M University
July '16 – June '17
Medical Student - Texas A&M University Medical School

Michael Bounajem
Research Technician II
University of Texas
March '16 – July '16
Medical Student - University of Texas

Shyam Vedantam
Research Technician II
University of Texas at Dallas
June '15 – June '16
Medical Student - University of North Texas Health Science Center

Ryan Rodriguez
Research Technician II
Our Lady of the Lake University
January '15 – June '16
Pharmacy Student - University of North Carolina

Brandon Powell
Research Assistant I
Baylor University
September '12 – December '15
Clinical Trials Representative - Medpace Inc.

Peter Firouzbakht
Research Technician II
University of Wisconsin
August '14 – July '15
Health Unit Coordinator - University of Wisconsin Hospitals and Clinics

Leslie McKown
Research Assistant I
University of Texas
April '12 – January '15
Engineering Masters Student - University of Texas at Dallas

Clinton Wanner
Research Assistant I
University of North Texas
March '12 – August '14
IT Masters Student - University of Texas at Dallas

Angelo Ramirez
Research Assistant I
Texas A & M University
June '12 – April '14
Medical Master's Student – University of North Texas Health Science Center

Hailey Eisner
Research Technician II
University of California at Davis
July '11 – May '12
Medical Student – University of North Texas College of Osteopathic Medicine

Kevin Hancock
Research Assistant I
Texas State University
June '10 – April '12
Medical Student – University of Texas Medical Branch at Galveston

Jesse Morris II
Research Associate
Baylor University
January '07 – March '12

Nick Lemley
Research Assistant I
University of the Incarnate Word
March '10 – March '12
Medical Master's Student – University of North Texas Health Science Center

Melanie Weiler
Intern Associate (FNEA)
University of Texas
January '07 – December '11

Adare McCarthy
Research Technician II
University of Texas
June '10 – May '11
Medical Student – Texas A&M University Medical School

Jennifer Thompson
Research Technician II
Texas A&M University
September '10 – May '11
Medical Student – Texas A&M University Medical School

Nathan Mitchell
Research Technician II
Texas Christian University
January '10 – April '11
Neuroscience Graduate Student – University of Texas Health Science Center San Antonio

Ramey Marshell
Research Technician II
University of Arkansas
September '09 – June '10
Medical Student – University of Arkansas

Sierra Porter
Research Assistant I
Stephen F. Austin University
April '07 – May '10
Physician's Assistant Masters Student – University of Washington

Iman Abdeshahian
Research Assistant I
Baylor University
September '06 – May '10
Dental Student – Arizona School of Dentistry

Katie Johnson
Research Technician II
Texas A&M University
June '09 – April '10
Physician's Assistant Masters Student – UT Southwestern School of Allied Health

Chase Guy
Research Assistant I
Louisiana Tech University
July '07 – July '09
Engineering Student – University of Texas Arlington

Jonathan Guevara
Research Assistant I
Baylor University
August '07 – June '09
Medical Student – University of Texas School of Medicine San Antonio Health Science Center

Justin Remsing
Research Assistant I
UT Arlington
March '06 – August '07
Medical Student – St. Matthews University School of Medicine

Brian Shirley
Research Assistant I
Lee University
March '04 – May '07
Medical Student – Edward College of Osteopathic Medicine (Virginia Tech University)

Paul Williams
Research Assistant I
Austin College
February '05 – May '07

Kerra Kepley
Research Technician II
Texas A&M University
May '06 – February '07
Medical Student – Texas A&M University Medical School

Erin Brewer
Research Assistant I
Texas A&M University
October '04 – August '06
Clinical Nutrition Masters Student – UT Southwestern School of Allied Health

Bobbie Jo Dodson
Research Technician II
Texas A&M University
May '05 – May '06
Medical Student – University of North Texas College of Osteopathic Medicine

A.J. Jernigan
Research Technician II
West Texas A & M University
July '05 – May '06
Medical Student – Texas Tech University Medical School

Bruce Boehne
STARS Temporary Staff Associate
University of California – Los Angeles
June '05 – August '05
Instructor – Zion Baptist School

Adam Melton
Research Assistant I
Texas A & M University
December '03 – March '05
Masters Student – University of Pittsburgh

Cris Pomajzl
Senior Histology Technician
University of Texas
May '98 – August '04
Histology Supervisor – Austin Pathology Reference Laboratories

David Sutcliffe
Research Assistant I
Texas A&M University
October '01 – August '04
Medical Student – UT Southwestern Medical School

Jennifer Schacherer
Research Technician II
Baylor University
April '03 – July '04
Nursing Student – University of Texas Arlington

Jeffrey Stark
Senior Histology Technician
Texas A&M University
July '98 – November '03
Histologist – Children's Medical Center, Dallas

Robert Webb
Senior Histology Technician
McMurry State University
September '95 – December '98
IT Engineer – Iron Mountain Document Security

Misty Rogers
Histology Technician
Mountain View College
November '93 – September '95

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