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Publications

  1. Baldwin, J., C.H. Michnoff, N.A. Malmquist, J. White, M.G. Roth, P.K. Rathod, and M.A. Phillips, High-throughput Screening for Potent and Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase. Journal of Biological Chemistry, 2005. 280(23): p. 21847-21853.
  2. Chen, X., J. Longgood, C. Michnoff, S. Wei, D.E. Frantz, and I. Bezprozvanny, High-throughput Screen for Small Molecule Inhibitors of Mint1-PDZ Domains. Assay and Drug Development Technologies, 2007. 5(6): p. 769-783.
  3. Germanas, J.P., S. Wang, A. Miner, W. Hao, and J.M. Ready, Discovery of small-molecule inhibitors of tyrosinase. Bioorganic & Medicinal Chemistry Letters, 2007. 17(24): p. 6871-6875.
  4. Phillips, M.A., P.K. Rathod, J. Baldwin, and R. Gujjar, Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity. 2007: USA.
  5. Whitehurst, A., B. Bodemann, J. Cardenas, D. Ferguson, L. Girard, M. Pay-ton, J. Minna, C. Michnoff, W. Hao, M. Roth, X. Xie, and M. White, Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature, 2007. 446: p. 815 - 819.
  6. Falck, J.R., D. Stewart, and V. Sperandio, Methods of Inhibiting Bacterial Virulence and Compounds Relating Thereto, in UTSD: 1854USP1. 2008.
  7. Ganesan, A.K., H. Ho, B. Bodemann, S. Petersen, J. Aruri, S. Koshy, Z. Richardson, L.Q. Le, T. Krasieva, M.G. Roth, P. Farmer, and M.A. White, Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. PLoS Genetics, 2008. 4(12): p. 1-12.
  8. Malmquist, N.A., R. Gujjar, P.K. Rathod, and M.A. Phillips, Analysis of Flavin Oxidation and Electron-Transfer Inhibition in Plasmodium falciparum Dihydroorotate Dehydrogenase†. Biochemistry, 2008. 47(8): p. 2466-2475.
  9. Phillips, M.A., R. Gujjar, N.A. Malmquist, J. White, M.F. El, J. Baldwin, and P.K. Rathod, Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitors with Potent and Selective Activity against the Malaria Parasite Plasmodium falciparum. J. Med. Chem., 2008. 51(Copyright (C) 2010 American Chemical Society (ACS). All Rights Reserved.): p. 3649-3653.
  10. Phillips, M.A., P.K. Rathod, J. Baldwin, and R. Gujjar, Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity. 2008: United States.
  11. Rasko, D.A., C.G. Moreira, D.R. Li, N.C. Reading, J.M. Ritchie, M.K. Waldor, N. Williams, R. Taussig, S. Wei, M. Roth, D.T. Hughes, J.F. Huntley, M.W. Fina, J.R. Falck, and V. Sperandio, Targeting QseC Signaling and Virulence for Antibiotic Development. Science, 2008. 321(5892): p. 1078-1080.
  12. Roth, M., B. Fontoura, S. Wei, and N. Satterly, NS1 Protein Inhibitors. 2008: United States.
  13. Sadek, H., B. Hannack, E. Choe, J. Wang, S. Latif, M.G. Garry, D.J. Garry, J. Longgood, D.E. Frantz, E.N. Olson, J. Hsieh, and J.W. Schneider, Cardiogenic small molecules that enhance myocardial repair by stem cells. Proceedings of the National Academy of Sciences, 2008. 105(16): p. 6063-6068.
  14. Schneider, J., J. Hsieh, D. Frantz, S.L. McKnight, and J.M. Ready, Preparation of isoxazoles or pyrazoles as inducers of neurogenesis for treating disease. 2008, The University of Texas System, USA . p. 128 pp.
  15. Schneider, J.W., Z. Gao, S. Li, M. Farooqi, T.-S. Tang, I. Bezprozvanny, D.E. Frantz, and J. Hsieh, Small-molecule activation of neuronal cell fate. Nat Chem Biol, 2008. 4(7): p. 408-410.
  16. Tang, W., M. Dodge, D. Gundapaneni, C. Michnoff, M. Roth, and L. Lum, A genome-wide RNAi screen for Wnt/β-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Proc. Natl. Acad. Sci. U. S. A., 2008. 105: p. 9697-9702.
  17. Cao, J., X.-J. Xie, S. Zhang, A. Whitehurst, and M. White, Bayesian optimal discovery procedure for simultaneous significance testing. BMC Bioinformatics, 2009. 10(1): p. 5.
  18. Chen, B., M.E. Dodge, W. Tang, J. Lu, Z. Ma, C.-W. Fan, S. Wei, W. Hao, J. Kilgore, N.S. Williams, M.G. Roth, J.F. Amatruda, C. Chen, and L. Lum, Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol., 2009. 5: p. 100-107.
  19. Chew, S.K., P. Chen, N. Link, K.A. Galindo, K. Pogue, and J.M. Abrams, Genome-wide silencing in Drosophila captures conserved apoptotic effectors. Nature, 2009. 460(7251): p. 123-127.
  20. Gujjar, R., A. Marwaha, F. El Mazouni, J. White, K.L. White, S. Creason, D.M. Shackleford, J. Baldwin, W.N. Charman, F.S. Buckner, S. Charman, P.K. Rathod, and M.A. Phillips, Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice. Journal of Medicinal Chemistry, 2009. 52(7): p. 1864-1872.
  21. He, S., L. Wang, L. Miao, T. Wang, F. Du, L. Zhao, and X. Wang, Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-α. Cell (Cambridge, MA, U. S.), 2009. 137: p. 1100-1111.
  22. Lum, L., M. Roth, B. Chen, C. Chen, M. Dodge, and W. Tang, Wnt protein signalling inhibitors. 2009, The University of Texas System, USA . p. 147 pp.
  23. Phillips, M.A., P.K. Rathod, R. Gujjar, A. Marwaha, and S. Charman, Dihydroorotate Dehydrogenase Inhibitors With Selective Anti-malarial Activity. 2009: United States.
  24. Roth, M., B. Fontoura, S. Wei, and N. Satterly, NS1 protein inhibitors for the treatment of viral infections, particularly influenza virus infection. 2009, The University of Texas System, USA . p. 46 pp.
  25. Salahudeen, A.A., J.W. Thompson, J.C. Ruiz, H.-W. Ma, L.N. Kinch, Q. Li, N.V. Grishin, and R.K. Bruick, An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis. Science, 2009. 326(5953): p. 722-726.
  26. Wang, J., P. Alexander, L. Wu, R. Hammer, O. Cleaver, and S.L. McKnight, Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism. Science (Washington, DC, U. S.), 2009. 325: p. 435-439.
  27. Wang, X., S. He, and L. Wang, Cell-based necrosis assay in mammalian cell expressing RIPK1 and RIP3, and use for screening necrosis inhibitors. 2009, Board of Regents, The University of Texas System, USA . p. 10pp.
  28. Karner, C.M., C.E. Merkel, M. Dodge, Z. Ma, J. Lu, C. Chen, L. Lum, and T.J. Carroll, Tankyrase is necessary for canonical Wnt signaling during kidney development. Dev. Dyn., 2010. 239: p. 2014-2023.
  29. Komurov, K., D. Padron, T. Cheng, M. Roth, K.P. Rosenblatt, and M.A. White, Comprehensive Mapping of the Human Kinome to Epidermal Growth Factor Receptor Signaling. Journal of Biological Chemistry, 2010. 285(27): p. 21134-21142.
  30. McKnight, S.L., A.A. Pieper, J.M. Ready, and B.J. De, Preparation of carbazolylaminopropanols and related compounds as pro-neurogenic compounds. 2010, University of Texas Southwestern Medical Center, USA . p. 222pp.
  31. McKnight, S.L. and J. Wang, Methods for engineering stem cells to facilitate threonine catabolism by inducing expression of L-threonine 3-dehydrogenase transgene. 2010, University of Texas, USA . p. 10pp.
  32. Pieper, A.A., S. Xie, E. Capota, S.J. Estill, J. Zhong, J.M. Long, G.L. Becker, P. Huntington, S.E. Goldman, C.-H. Shen, M. Capota, J.K. Britt, T. Kotti, K. Ure, D.J. Brat, N.S. Williams, K.S. MacMillan, J. Naidoo, L. Melito, J. Hsieh, B.J. De, J.M. Ready, and S.L. McKnight, Discovery of a proneurogenic, neuroprotective chemical. Cell (Cambridge, MA, U. S.), 2010. 142: p. 39-51.
  33. Qi, X., L. Wang, and F. Du, Novel Small Molecules Relieve Prothymosin α-Mediated Inhibition of Apoptosome Formation by Blocking Its Interaction with Apaf-1. Biochemistry, 2010. 49(9): p. 1923-1930.
  34. Whitehurst, A.W., Y. Xie, S.C. Purinton, K.M. Cappell, J.T. Swanik, B. Larson, L. Girard, J.O. Schorge, and M.A. White, Tumor Antigen Acrosin Binding Protein Normalizes Mitotic Spindle Function to Promote Cancer Cell Proliferation. Cancer Res., 2010. 70(19): p. 7652-7661.
  35. Alexander, P.B., J. Wang, and S.L. McKnight, Targeted killing of a mammalian cell based upon its specialized metabolic state. Proceedings of the National Academy of Sciences, 2011. 108(38): p. 15828-15833.
  36. Cenik, B., C.F. Sephton, C.M. Dewey, X. Xian, S. Wei, K. Yu, W. Niu, G. Coppola, S.E. Coughlin, S.E. Lee, D.R. Dries, S. Almeida, D.H. Geschwind, F.-B. Gao, B.L. Miller, R.V. Farese, B.A. Posner, G. Yu, and J. Herz, Suberoylanilide Hydroxamic Acid (Vorinostat) Up-regulates Progranulin Transcription. Journal of Biological Chemistry, 2011. 286(18): p. 16101-16108.
  37. Coteron, J.M., M.a. Marco, J. Esquivias, X. Deng, K.L. White, J. White, M. Koltun, F. El Mazouni, S. Kokkonda, K. Katneni, R. Bhamidipati, D.M. Shackleford, I.i. Angulo-Barturen, S.B. Ferrer, M.a.B.n. Jiménez-Díaz, F.-J. Gamo, E.J. Goldsmith, W.N. Charman, I. Bathurst, D. Floyd, D. Matthews, J.N. Burrows, P.K. Rathod, S.A. Charman, and M.A. Phillips, Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential. Journal of Medicinal Chemistry, 2011. 54(15): p. 5540-5561.
  38. Ganesan, S.M., J.M. Morrisey, H. Ke, H.J. Painter, K. Laroiya, M.A. Phillips, P.K. Rathod, M.W. Mather, and A.B. Vaidya, Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection. Molecular and Biochemical Parasitology, 2011. 177(1): p. 29-34.
  39. Gujjar, R., F. El Mazouni, K.L. White, J. White, S. Creason, D.M. Shackleford, X. Deng, W.N. Charman, I. Bathurst, J. Burrows, D.M. Floyd, D. Matthews, F.S. Buckner, S.A. Charman, M.A. Phillips, and P.K. Rathod, Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity in Mice. Journal of Medicinal Chemistry, 2011. 54(11): p. 3935-3949.
  40. Hu, Y., A.P.D.M. Espindola, N.A. Stewart, S. Wei, B.A. Posner, and J.B. MacMillan, Chromomycin SA analogs from a marine-derived Streptomyces sp. Bioorganic & Medicinal Chemistry, 2011. 19(17): p. 5183-5189.
  41. MacMillan, K.S., J. Naidoo, J. Liang, L. Melito, N.S. Williams, L. Morlock, P.J. Huntington, S.J. Estill, J. Longgood, G.L. Becker, S.L. McKnight, A.A. Pieper, J.K. De Brabander, and J.M. Ready, Development of Proneurogenic, Neuroprotective Small Molecules. J. Am. Chem. Soc., 2011. 133(5): p. 1428-1437.
  42. Mata, M.A., N. Satterly, G.A. Versteeg, D. Frantz, S. Wei, N. Williams, M. Schmolke, S. Pena-Llopis, J. Brugarolas, C.V. Forst, M.A. White, A. Garcia-Sastre, M.G. Roth, and B.M.A. Fontoura, Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor. Nat Chem Biol, 2011. 7(10): p. 712-719.
  43. McKnight, S.L., A.A. Pieper, J.M. Ready, and J.K. De Brabander, Preparation of carbazolylaminopropanols and related compounds as pro-neurogenic compounds. 2011.
  44. McKnight, S.L., A.A. Pieper, J.M. Ready, and J.K. De Brabander, Pro-neurogenic compounds. 2011.
  45. Orvedahl, A., R.S. Jr, G. Xiao, A. Ng, Z. Zou, Y. Tang, M. Narimatsu, C. Gilpin, Q. Sun, M. Roth, C.V. Forst, J.L. Wrana, Y.E. Zhang, K. Luby-Phelps, R.J. Xavier, Y. Xie, and B. Levine, Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature, 2011. 480(7375): p. 113-117.
  46. Phillips, M.A., P.K. Rathod, S. Charman, D. Floyd, J. Burrows, G. Matthews, A. Marwaha, R. Gujjar, and J. Conteron-Lopez, Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase. 2011: USA.
  47. Wu, X. and B.P. Tu, Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation. Molecular Biology of the Cell, 2011. 22(21): p. 4124-4133.
  48. Chen, P., X. Tu, F. Akdemir, S.K. Chew, A. Rothenfluh, and J.M. Abrams, Effectors of alcohol-induced cell killing in Drosophila. Cell Death Differ, 2012. 19(10): p. 1655-1663.
  49. Fontoura, B., A. Garcia-Sastre, G. Versteeg, M. Roth, and N. Satterly, Viral inhibitors. 2012, The University of Texas System, USA; Mount Sinai School of Medicine . p. 99pp.
  50. Hu, Y., E.D. Martinez, and J.B. MacMillan, Anthraquinones from a Marine-Derived Streptomyces spinoverrucosus. Journal of Natural Products, 2012. 75(10): p. 1759-1764.
  51. McKnight, S.L., A.A. Pieper, J.M. Ready, and J.K. De Brabander, Pro-neurogenic compounds. 2012.
  52. McKnight, S.L., A.A. Pieper, J.M. Ready, and J.K. De Brabander, Preparation of carbazolylaminopropanols and related compounds as pro-neurogenic compounds. 2012, University of Texas System, USA . p. 185 pp., Cont.-in-part of U.S. Ser. No. 832,056.
  53. Pan, E., M. Jamison, M. Yousufuddin, and J.B. MacMillan, Ammosamide D, an Oxidatively Ring Opened Ammosamide Analog from a Marine-Derived Streptomyces variabilis. Organic Letters, 2012. 14(9): p. 2390-2393.
  54. Russell, J.L., S.C. Goetsch, H.R. Aguilar, H. Coe, X. Luo, N. Liu, E. van Rooij, D.E. Frantz, and J.W. Schneider, Regulated Expression of pH Sensing G Protein-Coupled Receptor-68 Identified through Chemical Biology Defines a New Drug Target for Ischemic Heart Disease. ACS Chemical Biology, 2012. 7(6): p. 1077-1083.
  55. Schneider, J., J. Hsieh, D. Frantz, S.L. McKnight, and J.M. Ready, Isoxazole amides, derivatives and methods of chemical induction of neurogenesis. 2012, University of Texas System, USA . p. 60pp.
  56. Somalinga, B.R., C.E. Day, S. Wei, M.G. Roth, and P.J. Thomas, TDP-43 Identified from a Genome Wide RNAi Screen for SOD1 Regulators. PLoS ONE, 2012. 7(4): p. e35818.
  57. Sun, L., H. Wang, Z. Wang, S. He, S. Chen, D. Liao, L. Wang, J. Yan, W. Liu, X. Lei, and X. Wang, Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase. Cell, 2012. 148(1–2): p. 213-227.
  58. Wang, X., J.B. MacMillan, S. Huang, and M. Fang, Ectonucleoside triphosphate diphosphohydrolase-5 (ENTPD-5) inhibitors for treatment of cancer. 2012, The University of Texas System: United States.
  59. Wang, Z., H. Jiang, S. Chen, F. Du, and X. Wang, The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways. Cell, 2012. 148(1–2): p. 228-243.
  60. Zhang, L., P. Das, M. Schmolke, B. Manicassamy, Y. Wang, X. Deng, L. Cai, B.P. Tu, C.V. Forst, M.G. Roth, D.E. Levy, A. García-Sastre, J. de Brabander, M.A. Phillips, and B.M.A. Fontoura, Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export. The Journal of Cell Biology, 2012. 196(3): p. 315-326.
  61. Hu, Y., M.B. Potts, D. Colosimo, M.L. Herrera-Herrera, A.G. Legako, M. Yousufuddin, M.A. White, and J.B. MacMillan, Discoipyrroles A–D: Isolation, Structure Determination, and Synthesis of Potent Migration Inhibitors from Bacillus hunanensis. Journal of the American Chemical Society, 2013. 135(36): p. 13387-13392.
  62. Kilgore, J.A., X. Du, L. Melito, S. Wei, C. Wang, H.G. Chin, B. Posner, S. Pradhan, J.M. Ready, and N.S. Williams, Identification of DNMT1 Selective Antagonists Using a Novel Scintillation Proximity Assay. Journal of Biological Chemistry, 2013. 288(27): p. 19673-19684.
  63. Kim, Hyun S., S. Mendiratta, J. Kim, Chad V. Pecot, Jill E. Larsen, I. Zubovych, Bo Y. Seo, J. Kim, B. Eskiocak, H. Chung, E. McMillan, S. Wu, J. De Brabander, K. Komurov, Jason E. Toombs, S. Wei, M. Peyton, N. Williams, Adi F. Gazdar, Bruce A. Posner, R.A. Brekken, Anil K. Sood, Ralph J. Deberardinis, Michael G. Roth, John D. Minna, and Michael A. White, Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer. Cell, 2013. 155(3): p. 552-566.
  64. Liu, Y., S. Shoji-Kawata, R.M. Sumpter, Y. Wei, V. Ginet, L. Zhang, B. Posner, K.A. Tran, D.R. Green, R.J. Xavier, S.Y. Shaw, P.G.H. Clarke, J. Puyal, and B. Levine, Autosis is a Na+,K+-ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia. Proceedings of the National Academy of Sciences, 2013. 110(51): p. 20364-20371.
  65. Lum, L., M. Roth, B. Chen, M. Dodge, and C. Chen, Wnt protein signalling inhibitors and therapeutic uses thereof. 2013, University of Texas System, USA . p. 99 pp.
  66. Lum, L., M.G. Roth, B. Chen, C. Chen, M.E. Dodge, and W. Tang, Wnt protein signalling inhibitors. 2013, The Board of Regents of the University of Texas System, USA . p. No pp. given.
  67. Markowitz, S., J.K.V. Willson, B.A. Posner, J. Ready, Y. Zhang, H.-H. Tai, M. Moss, and M. Antczak, Compositions and methods of modulating 15-Hydroxy-prostaglandin dehydrogenase. 2013, Case Western Reserve University, USA; University of Texas System; University of Kentucky . p. 342pp.
  68. McKnight, S.L., A.A. Pieper, J.M. Ready, and J.K. De Brabander, Preparation of carbazolylaminopropanols and related compounds as pro-neurogenic compounds. 2013, University of Texas System, USA . p. 235 pp., Cont.-in-part of U.S. Ser. No. 177,981.
  69. O’Neal, M.A., B.A. Posner, C.J. Coates, and J.M. Abrams, A Cell-Based Screening Platform Identifies Novel Mosquitocidal Toxins. Journal of Biomolecular Screening, 2013. 18(6): p. 688-694.
  70. Pan, E., N.W. Oswald, A.G. Legako, J.M. Life, B.A. Posner, and J.B. MacMillan, Precursor-directed generation of amidine containing ammosamide analogs: ammosamides E-P. Chemical Science, 2013. 4(1): p. 482-488.
  71. Potts, M.B., H.S. Kim, K.W. Fisher, Y. Hu, Y.P. Carrasco, G.B. Bulut, Y.-H. Ou, M.L. Herrera-Herrera, F. Cubillos, S. Mendiratta, G. Xiao, M. Hofree, T. Ideker, Y. Xie, L.J.-s. Huang, R.E. Lewis, J.B. MacMillan, and M.A. White, Using Functional Signature Ontology (FUSION) to Identify Mechanisms of Action for Natural Products. Sci. Signal., 2013. 6(297): p. ra90-.
  72. Rogers, J.L., L. Bayeh, T.H. Scheuermann, J. Longgood, J. Key, J. Naidoo, L. Melito, C. Shokri, D.E. Frantz, R.K. Bruick, K.H. Gardner, J.B. MacMillan, and U.K. Tambar, Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor. Journal of Medicinal Chemistry, 2013. 56(4): p. 1739-1747.
  73. Scheuermann, T.H., Q. Li, H.-W. Ma, J. Key, L. Zhang, R. Chen, J.A. Garcia, J. Naidoo, J. Longgood, D.E. Frantz, U.K. Tambar, K.H. Gardner, and R.K. Bruick, Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol, 2013. 9(4): p. 271-276.
  74. Tang, H., G. Xiao, C. Behrens, J. Schiller, J. Allen, C.-W. Chow, M. Suraokar, A. Corvalan, J. Mao, M.A. White, I.I. Wistuba, J.D. Minna, and Y. Xie, A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non–Small Cell Lung Cancer Patients. Clin. Cancer Res., 2013. 19(6): p. 1577-1586.
  75. Wang, G., X. Wang, H. Yu, S. Wei, N. Williams, D.L. Holmes, R. Halfmann, J. Naidoo, L. Wang, L. Li, S. Chen, P. Harran, X. Lei, and X. Wang, Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat Chem Biol, 2013. 9(2): p. 84-89.
  76. Zhong, R., M.S. Kim, M.A. White, Y. Xie, and G. Xiao, SbacHTS: Spatial background noise correction for High-Throughput RNAi Screening. Bioinformatics, 2013. 29(17): p. 2218-2220.
  77. BRUICK, R., C. CALDWELL, D. FRANTZ, K.H. GARDNER, J. MACMILLAN, T.H. SCHEUERMANN, and U. TAMBAR, INHIBITION OF HIF-2[alpha] HETERODIMERIZATION WITH HIF1[beta] (ARNT). 2014, UNIV TEXAS.
  78. Bruick, R.K., C.G. Caldwell, D.E. Frantz, K.H. Gardner, J.B. MacMillan, T.H. Scheuermann, and U.K. Tambar, Inhibition of HIF-2α heterodimerization with HIF1β (ARNT). 2014, University of Texas System, USA . p. 119pp.
  79. Chau, V., S.K. Lim, W. Mo, C. Liu, A.J. Patel, R.M. McKay, S. Wei, B.A. Posner, J.K. De Brabander, N.S. Williams, L.F. Parada, and L.Q. Le, Preclinical Therapeutic Efficacy of a Novel Pharmacologic Inducer of Apoptosis in Malignant Peripheral Nerve Sheath Tumors. Cancer Research, 2014. 74(2): p. 586-597.
  80. Comerford, Sarah A., Z. Huang, X. Du, Y. Wang, L. Cai, Agnes K. Witkiewicz, H. Walters, Mohammed N. Tantawy, A. Fu, H.C. Manning, Jay D. Horton, Robert E. Hammer, Steven L. McKnight, and Benjamin P. Tu, Acetate Dependence of Tumors. Cell, 2014. 159(7): p. 1591-1602.
  81. Díaz-Martínez, L.A., Z.N. Karamysheva, R. Warrington, B. Li, S. Wei, X.-J. Xie, M.G. Roth, and H. Yu, Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation. The EMBO Journal, 2014. 33(17): p. 1960-1976.
  82. Fan, C.-W., B. Chen, I. Franco, J. Lu, H. Shi, S. Wei, C. Wang, X. Wu, W. Tang, Michael G. Roth, Noelle S. Williams, E. Hirsch, C. Chen, and L. Lum, The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation. Chemistry & Biology, 2014. 21(12): p. 1680-1689.
  83. Fu, P., M. Jamison, S. La, and J.B. MacMillan, Inducamides A–C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp. Organic Letters, 2014. 16(21): p. 5656-5659.
  84. Fu, P., M. Johnson, H. Chen, B.A. Posner, and J.B. MacMillan, Carpatamides A–C, Cytotoxic Arylamine Derivatives from a Marine-Derived Streptomyces sp. Journal of Natural Products, 2014. 77(5): p. 1245-1248.
  85. Iscla, I., R. Wray, S. Wei, B. Posner, and P. Blount, Streptomycin potency is dependent on MscL channel expression. Nat Commun, 2014. 5.
  86. Liao, D., L. Sun, W. Liu, S. He, X. Wang, and X. Lei, Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein. MedChemComm, 2014. 5(3): p. 333-337.
  87. Lum, L. and C. Chen, Highly potent inhibitors of porcupine. 2014, The University of Texas System, USA . p. 76pp.
  88. McKnight, S.L., A.A. Pieper, J.M. Ready, and J.K. De Brabander, Preparation of carbazolylaminopropanols and related compounds as pro-neurogenic compounds. 2014, University of Texas System, USA . p. 390pp.
  89. McKnight, S.L., A.A. Pieper, J.M. Ready, J.K. De Brabander, and J.M. Zigman, Preparation of carbazolylaminopropanols and related compounds as anti-depression compounds. 2014, University of Texas System, USA . p. 249 pp., Cont.-in-part of U.S. Ser. No. 594,223.
  90. McKnight, S.L., A.A. Pieper, J.M. Ready, and E. Fernandez, Pro-neurogenic compounds as therapeutic agents for the treatment of neuropsychiatric and/or neurodegenerative diseases. 2014, University of Texas System, USA . p. 38pp.; Chemical Indexing Equivalent to 160:363826 (WO).
  91. Morrison, S., E. Piskounova, and U. Eskiocak, Combination treatments for melanoma. 2014, University of Texas System, USA . p. 18pp.; Chemical Indexing Equivalent to 160:420915 (WO).
  92. Morrison, S., E. Piskounova, and U. Eskiocak, Treatments for melanoma using mono- and combination therapies. 2014, University of Texas System, USA . p. 24pp.; Chemical Indexing Equivalent to 160:420916 (WO).
  93. Morrison, S.J., E. Piskounova, and U. Eskiocak, Treatments for Melanoma, in United States, U. States, Editor. 2014: United States.
  94. Tso, S.-C., W.-J. Gui, C.-Y. Wu, J.L. Chuang, X. Qi, K.J. Skvorak, K. Dorko, A.L. Wallace, L.K. Morlock, B.H. Lee, S.M. Hutson, S.C. Strom, N.S. Williams, U.K. Tambar, R.M. Wynn, and D.T. Chuang, Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase. Journal of Biological Chemistry, 2014. 289(30): p. 20583-20593.
  95. Wang, G., T. Han, D. Nijhawan, P. Theodoropoulos, J. Naidoo, S. Yadavalli, H. Mirzaei, Andrew A. Pieper, Joseph M. Ready, and Steven L. McKnight, P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage. Cell, 2014. 158(6): p. 1324-1334.
  96. Yarbrough, M.L., K. Zhang, R. Sakthivel, C.V. Forst, B.A. Posner, G.N. Barber, M.A. White, and B.M.A. Fontoura, Primate-specific miR-576-3p sets host defense signalling threshold. Nat Commun, 2014. 5: p. 1 - 10.
  97. Zhong, R., X. Dong, B. Levine, Y. Xie, and G. Xiao, iScreen: Image-Based High-Content RNAi Screening Analysis Tools. Journal of Biomolecular Screening, 2014.
  98. Zhong, R., J. Kim, H.S. Kim, M. Kim, L. Lum, B. Levine, G. Xiao, M.A. White, and Y. Xie, Computational detection and suppression of sequence-specific off-target phenotypes from whole genome RNAi screens. Nucleic Acids Research, 2014. 42(13): p. 8214-8222.
  99. Chuang, D.T., S.-C. Tso, X. Qi, W.-J. Gui, C.-Y. Wu, J.L. Chuang, U.K. Tambar, and R.M. Wynn, Inhibitors of mitochondrial pyruvate dehydrogenase kinase isoforms 1-4 and uses thereof. 2015, Board of Regents, University of Texas System, USA . p. 186pp.
  100. Debrabander, J., J.W. Shay, and W. Wang, Preparation of small molecule anticancer therapeutics targeting truncated adenomatous polyposis coli (APC) proteins. 2015, USA . p. 248pp.
  101. Fu, P. and J.B. MacMillan, Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora. Journal of Natural Products, 2015. 78(3): p. 548-551.
  102. Garcia-Rodriguez, J., S. Mendiratta, M.A. White, X.-S. Xie, and J.K. De Brabander, Synthesis and structure–activity studies of the V-ATPase inhibitor saliphenylhalamide (SaliPhe) and simplified analogs. Bioorganic & Medicinal Chemistry Letters, 2015. 25(20): p. 4393-4398.
  103. Liu, Y. and B. Levine, Autosis and autophagic cell death: the dark side of autophagy. Cell Death Differ, 2015. 22(3): p. 367-376.
  104. Lum, L., M. Roth, B. Chen, M. Dodge, and C. Chen, Wnt protein signalling inhibitors. 2015, The Board of Regents of the University of Texas System, USA . p. No pp. given.
  105. Markowitz, S., J.K.V. Willson, B. Posner, J. Ready, M. Antczak, Y. Zhang, A. Desai, S. Gerson, and W. Greenlee, Preparation of thienopyridines and similar bicyclic heterocyclic compounds as modulators of 15-hydroxyprostaglandin dehydrogenase type I for therapy. 2015, Case Western Reserve University, USA; University of Texas System . p. 385pp.
  106. Markowitz, S., J.K.V. Willson, B.A. Posner, J. Ready, Y. Zhang, H.-H. Tai, M. Moss, M. Antczak, S. Gerson, K. Bae, S.Y. Yang, and A. Desai, Preparation of aminoheteroaromatic compounds, their compositions and methods of modulating 15-PGDH activity. 2015, Case Western Reserve University, USA; Board of Regents of the University of Texas System; University of Kentucky Research Foundation . p. 205pp.
  107. McKnight, S.L., J.M. Ready, A.A. Pieper, G. Wang, and T. Han, Screening methods for identifying neuroprotective compds. and therapeutic uses thereof. 2015, University of Texas System, USA; University of Iowa Research Foundation . p. 146pp.
  108. Morrison, S.J. and U. Eskiocak, Combination therapies for treatment for melanoma. 2015, The Board of Regents of the University of Texas System, USA . p. 41pp.
  109. Ready, J.M., D. Nijhawan, S.S. Gonzales, and P. Theodoropoulos, Preparation of benzothiophenes and other compounds and methods and compositions for selective and targeted cancer therapy. 2015, Board of Regents of the University of Texas System, USA.
  110. Scheuermann, T.H., D. Stroud, C.E. Sleet, L. Bayeh, C. Shokri, H. Wang, C.G. Caldwell, J. Longgood, J.B. MacMillan, R.K. Bruick, K.H. Gardner, and U.K. Tambar, Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2. Journal of Medicinal Chemistry, 2015. 58(15): p. 5930-5941.
  111. Thorne, C.A., C. Wichaidit, A.D. Coster, B.A. Posner, L.F. Wu, and S.J. Altschuler, GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol, 2015. 11(1): p. 58-63.
  112. Unger, R., J. De Brabander, M. Roth, and M. Evans, Compositions and methods to treat the bihormonal disorder in diabetes comprising glucagon depleting compound. 2015, The University of Texas Southwestern Medical Center, USA . p. 57pp.
  113. Yu, G., J. Herz, B. Posner, and B. Cenik, Isoxazole treatments for frontotemporal dementia. 2015, The Board of Regents of the University of Texas System, USA . p. 57pp.
  114. Zhang, Y., A. Desai, S.Y. Yang, K.B. Bae, M.I. Antczak, S.P. Fink, S. Tiwari, J.E. Willis, N.S. Williams, D.M. Dawson, D. Wald, W.-D. Chen, Z. Wang, L. Kasturi, G.A. Larusch, L. He, F. Cominelli, L. Di Martino, Z. Djuric, G.L. Milne, M. Chance, J. Sanabria, C. Dealwis, D. Mikkola, J. Naidoo, S. Wei, H.-H. Tai, S.L. Gerson, J.M. Ready, B. Posner, J.K.V. Willson, and S.D. Markowitz, Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science, 2015. 348(6240).
  115. Chen, W., H. Hill, A. Christie, M.S. Kim, E. Holloman, A. Pavia-Jimenez, F. Homayoun, Y. Ma, N. Patel, P. Yell, G. Hao, Q. Yousuf, A. Joyce, I. Pedrosa, H. Geiger, H. Zhang, J. Chang, K.H. Gardner, R.K. Bruick, C. Reeves, T.H. Hwang, K. Courtney, E. Frenkel, X. Sun, N. Zojwalla, T. Wong, J.P. Rizzi, E.M. Wallace, J.A. Josey, Y. Xie, X.-J. Xie, P. Kapur, R.M. McKay, and J. Brugarolas, Targeting renal cell carcinoma with a HIF-2 antagonist. Nature, 2016. 539(7627): p. 112-117.
  116. Cho, H., X. Du, J.P. Rizzi, E. Liberzon, A.A. Chakraborty, W. Gao, I. Carvo, S. Signoretti, R.K. Bruick, J.A. Josey, E.M. Wallace, and W.G. Kaelin, On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models. Nature, 2016. 539: p. 107.
  117. Choi, S.H., D. Bosnakovski, J.M. Strasser, E.A. Toso, M.A. Walters, and M. Kyba, Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen. Journal of Biomolecular Screening, 2016. 21(7): p. 680-688.
  118. DeBrabander, J., L.F. Parada, S.K. LIM, Q. LIANG, H.-y. WANG, and Y. Shi, Substituted benzimidazolium, pyrido-imidazolium, or pyrazino-imidazolium compounds as chemotherapeutics, T.B.O.R.O.T.U.O.T. SYSTEM, Editor. 2016.
  119. Debrabander, J., J.W. Shay, W. Wang, D. Nijhawan, and P. Theodoropoulos, Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis. 2016, Board of Regents of the University of Texas System, USA . p. 111 pp., Cont.-in-part of U.S. Ser. No. 482,659.
  120. Eskiocak, U., V. Ramesh, J.G. Gill, Z. Zhao, S.W. Yuan, M. Wang, T. Vandergriff, M. Shackleton, E. Quintana, T.M. Johnson, R.J. DeBerardinis, and S.J. Morrison, Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma. Nature Communications, 2016. 7: p. 12336.
  121. Evans, M.R., S. Wei, B.A. Posner, R.H. Unger, and M.G. Roth, An AlphaScreen Assay for the Discovery of Synthetic Chemical Inhibitors of Glucagon Production. Journal of Biomolecular Screening, 2016. 21(4): p. 325-332.
  122. Fu, P., S. La, and J.B. MacMillan, 1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus. Journal of Natural Products, 2016. 79(3): p. 455-462.
  123. Fu, P.L., Aaron; La, Scott; MacMillan, John B, Discovery, characterization, and analog synthesis of bohemamine dimers generated by non-enzymatic biosynthesis. Chemistry - A European Journal, 2016. 22(10): p. 3491-3495.
  124. Kang, J., C.-H. Hsu, Q. Wu, S. Liu, A.D. Coster, B.A. Posner, S.J. Altschuler, and L.F. Wu, Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines. Nat Biotech, 2016. 34(1): p. 70-77.
  125. Kaufman, Sarah K., David W. Sanders, Talitha L. Thomas, Allison J. Ruchinskas, J. Vaquer-Alicea, Apurwa M. Sharma, Timothy M. Miller, and Marc I. Diamond, Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo. Neuron, 2016. 92(4): p. 796-812.
  126. Kim, J., E. McMillan, H.S. Kim, N. Venkateswaran, G. Makkar, J. Rodriguez-Canales, P. Villalobos, J.E. Neggers, S. Mendiratta, S. Wei, Y. Landesman, W. Senapedis, E. Baloglu, C.-W.B. Chow, R.E. Frink, B. Gao, M. Roth, J.D. Minna, D. Daelemans, I.I. Wistuba, B.A. Posner, P.P. Scaglioni, and M.A. White, XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer. Nature, 2016. 538(7623): p. 114-117.
  127. Lum, L., C. Chen, X. Zhang, O. Kulak, and X. Wu, Indolinyl-sulfonamide inhibitors of tankyrase and methods of use thereof. 2016, The Board of Regents of the University of Texas System, USA . p. 82pp.
  128. Markowitz, S.D., J. Ready, Y. Zhang, M. Antczak, J.K.V. Willson, B.A. Posner, and W. Greenlee, Compositions and methods of modulating short-chain dehydrogenase activity. 2016, Case Western Reserve University, USA; Board of Regents of the University of Texas System . p. 254pp.
  129. Morrison, S. and E. Piskounova, Treatment for cancer metastasis using combination therapies. 2016, The Board of Regents of the University of Texas System, USA . p. 92pp.
  130. Phillips, M., S.A. Charman, P.K. Rathod, D. Matthews, and D. Waterson, Preparation of substituted triazolopyrimidines as antimalarial agents. 2016, Board of Regents of the University of Texas System, USA; Monash University; University of Washington; MMV Medicines for Malaria Venture . p. 21pp.; Chemical Indexing Equivalent to 165:440839 (WO).
  131. Piala, A.T., R. Akella, M.B. Potts, S.A. Dudics-Giagnocavo, H. He, S. Wei, M.A. White, B.A. Posner, and E.J. Goldsmith, Discovery of novel TAOK2 inhibitor scaffolds from high-throughput screening. Bioorganic & Medicinal Chemistry Letters, 2016. 26(16): p. 3923-3927.
  132. Ramirez, M., S. Rajaram, R.J. Steininger, D. Osipchuk, M.A. Roth, L.S. Morinishi, L. Evans, W. Ji, C.-H. Hsu, K. Thurley, S. Wei, A. Zhou, P.R. Koduru, B.A. Posner, L.F. Wu, and S.J. Altschuler, Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells. Nat Commun, 2016. 7: p. 1.
  133. Rathod, P.K., D. Floyd, J. Burrows, A. Marwaha, R. Gujjar, J. Coteron-Lopez, M. Phillips, S.A. Charman, and D. Matthews, Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase. 2016, Board of Regents, The University of Texas System, USA; Mmv Medicines for Malaria Venture; University of Washington; Monash University, Clayton; Glaxosmithkline Investigacion Y Desarrollo, S.L; Medicines for Malaria Venture . p. No pp. given.
  134. Rujirawanich, J., S. Kim, A.-J. Ma, J.R. Butler, Y. Wang, C. Wang, M. Rosen, B. Posner, D. Nijhawan, and J.M. Ready, Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives. Journal of the American Chemical Society, 2016. 138(33): p. 10561-10570.
  135. Theodoropoulos, P.C., S.S. Gonzales, S.E. Winterton, C. Rodriguez-Navas, J.S. McKnight, L.K. Morlock, J.M. Hanson, B. Cross, A.E. Owen, Y. Duan, J.R. Moreno, A. Lemoff, H. Mirzaei, B.A. Posner, N.S. Williams, J.M. Ready, and D. Nijhawan, Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase. Nat Chem Biol, 2016. 12(4): p. 218-225.
  136. Wallace, E.M., J.P. Rizzi, G. Han, P.M. Wehn, Z. Cao, X. Du, T. Cheng, R.M. Czerwinski, D.D. Dixon, B.S. Goggin, J.A. Grina, M.M. Halfmann, M.A. Maddie, S.R. Olive, S.T. Schlachter, H. Tan, B. Wang, K. Wang, S. Xie, R. Xu, H. Yang, and J.A. Josey, A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma. Cancer Research, 2016. 76(18): p. 5491-5500.
  137. Witkiewicz, Agnieszka K., U. Balaji, C. Eslinger, E. McMillan, W. Conway, B. Posner, Gordon B. Mills, Eileen M. O’Reilly, and Erik S. Knudsen, Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer. Cell Reports, 2016. 16(7): p. 2017-2031.
  138. Zhang, L., P.C. Theodoropoulos, U. Eskiocak, W. Wang, Y.-A. Moon, B. Posner, N.S. Williams, W.E. Wright, S.B. Kim, D. Nijhawan, J.K. De Brabander, and J.W. Shay, Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. Science Translational Medicine, 2016. 8(361): p. 361ra140-361ra140.
  139. Zubovych, I.O., A. Sethi, A. Kulkarni, V. Tagal, and M.G. Roth, A Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non–Small Cell Lung Cancer Cell Lines. Mol. Cancer Ther., 2016. 15(1): p. 23-36.
  140. Antczak, M.I., Y. Zhang, C. Wang, J. Doran, J. Naidoo, S. Voruganti, N.S. Williams, S.D. Markowitz, and J.M. Ready, Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair. Journal of Medicinal Chemistry, 2017. 60(9): p. 3979-4001.
  141. Cooper, J.M., Y.-H. Ou, E.A. McMillan, R.M. Vaden, A. Zaman, B.O. Bodemann, G. Makkar, B.A. Posner, and M.A. White, TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer. Cancer Research, 2017. 77(18): p. 5077-5094.
  142. Debrabander, J. and L. Parada, Benzamide or benzamine compounds useful as anticancer agents for the treatment of human cancers. 2017, The Board of Regents of the University of Texas System, USA . p. 298pp.
  143. Frankel, A.E., U. Eskiocak, J.G. Gill, S. Yuan, V. Ramesh, T.W. Froehlich, C. Ahn, and S.J. Morrison, Digoxin Plus Trametinib Therapy Achieves Disease Control in BRAF Wild-Type Metastatic Melanoma Patients. Neoplasia, 2017. 19(4): p. 255-260.
  144. Fu, P., S. La, and J.B. MacMillan, Daryamide Analogues from a Marine-Derived Streptomyces species. Journal of Natural Products, 2017. 80(4): p. 1096-1101.
  145. Goldsmith, E.J., A.T. Piala, and M.B. Potts, Compositions and methods comprising Thousand-And-One Kinase 2 (TAOK2) inhibitors and modulators of autophagy for cancer treatment. 2017, USA . p. 23pp.
  146. Kishore, A.H., H. Liang, M. Kanchwala, C. Xing, T. Ganesh, Y. Akgul, B. Posner, J.M. Ready, S.D. Markowitz, and R.A. Word, Prostaglandin dehydrogenase is a target for successful induction of cervical ripening. Proceedings of the National Academy of Sciences, 2017. 114(31): p. E6427-E6436.
  147. Markowitz, S., A. Desai, S. Gerson, and J. Ready, Inhibitors of short-chain dehydrogenase such as 15-hydroxyprostaglandin dehydrogenase (15-PGDH) for modulating hematopoietic stem cells and hematopoiesis. 2017, Case Western Reserve University, USA; Board of Regents of the University of Texas System . p. 100 pp., Cont.-in-part of U.S. Ser. No. 29,943.
  148. Mohanakrishnan, A., T.V.M. Tran, M. Kumar, H. Chen, B.A. Posner, and S.L. Schmid, A high-throughput assay to identify robust inhibitors of dynamin GTPase activity. bioRxiv, 2017.
  149. Mohanakrishnan, A., T.V.M. Tran, M. Kumar, H. Chen, B.A. Posner, and S.L. Schmid, A highly-sensitive high throughput assay for dynamin's basal GTPase activity. PLOS ONE, 2017. 12(9): p. e0185639.
  150. Moon, J., H. Zhou, L.-s. Zhang, W. Tan, Y. Liu, S. Zhang, L.K. Morlock, X. Bao, S.P. Palecek, J.Q. Feng, N.S. Williams, J.F. Amatruda, E.N. Olson, R. Bassel-Duby, and L. Lum, Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist. Proceedings of the National Academy of Sciences, 2017. 114(7): p. 1649 - 1654.
  151. Tagal, V., S. Wei, W. Zhang, R.A. Brekken, B.A. Posner, M. Peyton, L. Girard, T. Hwang, D.A. Wheeler, J.D. Minna, M.A. White, A.F. Gazdar, and M.G. Roth, SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers. Nature Communications, 2017. 8: p. 14098.
  152. Volkov, O.A., C.C. Cosner, A.J. Brockway, M. Kramer, M. Booker, S. Zhong, A. Ketcherside, S. Wei, J. Longgood, M. McCoy, T.E. Richardson, S.A. Wring, M. Peel, J.D. Klinger, B.A. Posner, J.K. De Brabander, and M.A. Phillips, Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay. ACS Infectious Diseases, 2017. 3: p. 512 - 526.
  153. Wang, C., H. Niederstrasser, P.M. Douglas, R. Lin, J. Jaramillo, Y. Li, N.W. Olswald, A. Zhou, E.A. McMillan, S. Mendiratta, Z. Wang, T. Zhao, Z. Lin, M. Luo, G. Huang, R.A. Brekken, B.A. Posner, J.B. MacMillan, J. Gao, and M.A. White, Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nature Communications, 2017. 8(1): p. 2270.
  154. Zhang, L. and J.W. Shay, Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer. JNCI: Journal of the National Cancer Institute, 2017. 109(8): p. djw332-djw332.
  155. Zhong, B., L. Sun, H. Shi, J. Li, C. Chen, and Z. Chen, Thiazolidinediones and related compounds as cGAS antagonists and their preparation. 2017, Immune Sensor, LLC, USA; University of Texas System . p. 270pp.
  156. Zhou, H., M.G. Morales, H. Hashimoto, M.E. Dickson, K. Song, W. Ye, M.S. Kim, H. Niederstrasser, Z. Wang, B. Chen, B.A. Posner, R. Bassel-Duby, and E.N. Olson, ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression. Genes & Development, 2017. 31(17): p. 1770-1783.
  157. Chiang, W.-C., Y. Wei, Y.-C. Kuo, S. Wei, A. Zhou, Z. Zou, J. Yehl, M.J. Ranaghan, A. Skepner, J.A. Bittker, J.R. Perez, B.A. Posner, and B. Levine, High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding. ACS Chemical Biology, 2018. 13(8): p. 2247-2260.
  158. Courtney, K.D., J.R. Infante, E.T. Lam, R.A. Figlin, B.I. Rini, J. Brugarolas, N.J. Zojwalla, A.M. Lowe, K. Wang, E.M. Wallace, J.A. Josey, and T.K. Choueiri, Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma. Journal of Clinical Oncology, 2018. 36(9): p. 867-874.
  159. Desai, A., Y. Zhang, Y. Park, D.M. Dawson, G.A. Larusch, L. Kasturi, D. Wald, J.M. Ready, S.L. Gerson, and S.D. Markowitz, A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independent of age, transplant dose, and G-CSF support. Haematologica, 2018.
  160. Kalwat, M.A., I.H. Hwang, J. Macho, M.G. Grzemska, J.Z. Yang, K. McGlynn, J.B. MacMillan, and M.H. Cobb, Chromomycin A2 potently inhibits glucose-stimulated insulin secretion from pancreatic β cells. Journal of General Physiology, 2018. 150(12): p. 1747-1757.
  161. Llanos-Cuentas, A., M. Casapia, R. Chuquiyauri, J.-C. Hinojosa, N. Kerr, M. Rosario, S. Toovey, R.H. Arch, M.A. Phillips, F.D. Rozenberg, J. Bath, C.L. Ng, A.N. Cowell, E.A. Winzeler, D.A. Fidock, M. Baker, J.J. Möhrle, R. Hooft van Huijsduijnen, N. Gobeau, N. Araeipour, N. Andenmatten, T. Rückle, and S. Duparc, Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study. The Lancet Infectious Diseases, 2018. 18(8): p. 874-883.
  162. Luthra, P., J. Liang, C.A. Pietzsch, S. Khadka, M.R. Edwards, S. Wei, S. De, B. Posner, A. Bukreyev, J.M. Ready, and C.F. Basler, A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication. Antiviral Research, 2018. 150: p. 193-201.
  163. Luthra, P., J. Naidoo, C.A. Pietzsch, S. De, S. Khadka, M. Anantpadma, C.G. Williams, M.R. Edwards, R.A. Davey, A. Bukreyev, J.M. Ready, and C.F. Basler, Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses. Antiviral Research, 2018. 158: p. 288-302.
  164. Markowitz, S., M. Antczak, J. Ready, and Y. Zhang, Preparation of thienopyridines and related compounds, their compositions and methods of modulating short-chain dehydrogenase activity. 2018, Case Western Reserve University, USA; Board of Regents, The University of Texas System . p. 332pp.
  165. Markowitz, S., W.J. Ho, Y. Yuan, M. Jain, M. Sabeh, J. Ready, and N. Williams, Inhibitors of 15-hydroxy prostaglandin dehydrogenase (15-PGDH) activity for treating coronary disorders. 2018, Case Western Reserve University, USA; Board of Regents of the University of Texas . p. 112 pp.
  166. Markowitz, S., J. Ready, and A. Pieper, Preparation of alkylsulfinyl-, alkylsulfonyl- and alkylthio- thieno[2,3-b]pyridinamines as inhibitors of short-chain dehydrogenase activity for promoting neurogenesis and inhibiting nerve cell death. 2018, Case Western Reserve University, USA; University of Texas Southwestern Medical Center; University of Iowa Research Foundation . p. 168pp.
  167. Markowitz, S.D., Y. Yuan, Y. Zhang, J. Ready, and B. Hu, Preparation of pyrazolopyrimidine and quinoxaline derivatives for modulating short-chain dehydrogenase activity. 2018, Case Western Reserve University, USA; Board of Regents of the University of Texas System . p. 228pp.
  168. McMillan, E.A., M.-J. Ryu, C.H. Diep, S. Mendiratta, J.R. Clemenceau, R.M. Vaden, J.-H. Kim, T. Motoyaji, K.R. Covington, M. Peyton, K. Huffman, X. Wu, L. Girard, Y. Sung, P.-H. Chen, P.L. Mallipeddi, J.Y. Lee, J. Hanson, S. Voruganti, Y. Yu, S. Park, J. Sudderth, C. DeSevo, D.M. Muzny, H. Doddapaneni, A. Gazdar, R.A. Gibbs, T.-H. Hwang, J.V. Heymach, I. Wistuba, K.R. Coombes, N.S. Williams, D.A. Wheeler, J.B. MacMillan, R.J. Deberardinis, M.G. Roth, B.A. Posner, J.D. Minna, H.S. Kim, and M.A. White, Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell, 2018. 173(4): p. 864-878.e29.
  169. Nichols, B.A., N.W. Oswald, E.A. McMillan, K. McGlynn, J. Yan, M.S. Kim, J. Saha, P.L. Mallipeddi, S.A. LaDuke, P.A. Villalobos, J. Rodriguez-Canales, I.I. Wistuba, B.A. Posner, A.J. Davis, J.D. Minna, J.B. MacMillan, and A.W. Whitehurst, HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress. Cancer Research, 2018. 78(21): p. 6196-6208.
  170. Sharma, A.M., T.L. Thomas, D.R. Woodard, O.M. Kashmer, and M.I. Diamond, Tau monomer encodes strains. eLife, 2018. 7: p. e37813.
  171. Thorne, C.A., I.W. Chen, L.E. Sanman, M.H. Cobb, L.F. Wu, and S.J. Altschuler, Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization. Developmental Cell, 2018. 44(5): p. 624-633.e4.
  172. Volkov, O.A., A.J. Brockway, S.A. Wring, M. Peel, Z. Chen, M.A. Phillips, and J.K. De Brabander, Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase. Journal of Medicinal Chemistry, 2018. 61(3): p. 1182-1203.
  173. Wehn, P.M., J.P. Rizzi, D.D. Dixon, J.A. Grina, S.T. Schlachter, B. Wang, R. Xu, H. Yang, X. Du, G. Han, K. Wang, Z. Cao, T. Cheng, R.M. Czerwinski, B.S. Goggin, H. Huang, M.M. Halfmann, M.A. Maddie, E.L. Morton, S.R. Olive, H. Tan, S. Xie, T. Wong, J.A. Josey, and E.M. Wallace, Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385). Journal of Medicinal Chemistry, 2018. 61(21): p. 9691-9721.
  174. Winterton, S.E., E. Capota, X. Wang, H. Chen, P.L. Mallipeddi, N.S. Williams, B.A. Posner, D. Nijhawan, and J.M. Ready, Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase. Journal of Medicinal Chemistry, 2018. 61(12): p. 5199-5221.
  175. Yarravarapu, N., C. Chen, L. Lum, L. You, C. Zhang, X. Wang, and L. Zhang, Preparation of disubstituted and trisubtituted 1,2,3-triazoles as Wnt inhibitors for the treatment of diseases. 2018, The Board of Regents of the University of Texas System, USA . p. 86pp.
  176. Zhang, L., S.B. Kim, K. Luitel, and J.W. Shay, Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells. Molecular Cancer Therapeutics, 2018. 17(5): p. 943-951.
  177. DE BRABANDER, J., D. ROSENBAUM, Q. LIANG, and W. WANG, OX2R COMPOUNDS, U.o.T.B.o. Reagents, Editor. 2019, University of Texas Board of Reagents: US.
  178. De Brabander, J., D. Rosenbaum, Q. Liang, and W. Wang, Benzimidazolimine derivatives as OX2R agonists and their preparation. 2019, Board of Regents, The University of Texas System, USA . p. 343pp.
  179. Gao, J., M.A. White, C. Wang, Y. Li, B. Posner, and G. Huang, Novel transcription factor TFEB pathway agonists for treating metabolic disorders and age-related diseases. 2019, The Board of Regents of the University of Texas System, USA . p. 141pp.
  180. Kjalarsdottir, L., S.A. Tersey, M. Vishwanath, J.-C. Chuang, B.A. Posner, R.G. Mirmira, and J.J. Repa, 1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor. The Journal of Steroid Biochemistry and Molecular Biology, 2019. 185: p. 17-26.
  181. McMillan, E.A., G. Kwon, J.R. Clemenceau, K.W. Fisher, R.M. Vaden, A.F. Shaikh, B.K. Neilsen, D. Kelly, M.B. Potts, Y.-J. Sung, S. Mendiratta, S.K. Hight, Y. Lee, J.B. MacMillan, R.E. Lewis, H.S. Kim, and M.A. White, A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery. Cell Chem. Biol., 2019. 26(10): p. 1380-1392.e6.
  182. Shi, Y., S.K. Lim, Q. Liang, S.V. Iyer, H.-Y. Wang, Z. Wang, X. Xie, D. Sun, Y.-J. Chen, V. Tabar, P. Gutin, N. Williams, J.K. De Brabander, and L.F. Parada, Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature, 2019. 567(7748): p. 341-346.
  183. Tuladhar, R., N. Yarravarapu, Y. Ma, C. Zhang, J. Herbert, J. Kim, C. Chen, and L. Lum, Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN). Journal of Biological Chemistry, 2019. 294(16): p. 6273-6282.
  184. Wang, W., L. Zhang, L. Morlock, N.S. Williams, J.W. Shay, and J.K. De Brabander, Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC). Journal of Medicinal Chemistry, 2019. 62(10): p. 5217-5241.
  185. White, J., S.K. Dhingra, X. Deng, F. El Mazouni, M.C.S. Lee, G.A. Afanador, A. Lawong, D.R. Tomchick, C.L. Ng, J. Bath, P.K. Rathod, D.A. Fidock, and M.A. Phillips, Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. ACS Infectious Diseases, 2019. 5(1): p. 90-101.
  186. Word, R.A., H.K. Annavarapu, B. Posner, J. Ready, and S. Markowitz, Compositions and methods for modulating cervical ripening. 2019, Case Western Reserve University, USA; University of Texas Southwestern Medical . p. 132pp.
  187. Xu, R., K. Wang, J.P. Rizzi, H. Huang, J.A. Grina, S.T. Schlachter, B. Wang, P.M. Wehn, H. Yang, D.D. Dixon, R.M. Czerwinski, X. Du, E.L. Ged, G. Han, H. Tan, T. Wong, S. Xie, J.A. Josey, and E.M. Wallace, 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma. Journal of Medicinal Chemistry, 2019. 62(15): p. 6876-6893.
  188. Yu, Y., Q. Yu, and X. Zhang, Allosteric inhibition of HIF-2α as a novel therapy for clear cell renal cell carcinoma. Drug Discovery Today, 2019. 24(12): p. 2332-2340.
  189. Courtney, K.D., Y. Ma, A. Diaz de Leon, A. Christie, Z. Xie, L. Woolford, N. Singla, A. Joyce, H. Hill, A.J. Madhuranthakam, Q. Yuan, Y. Xi, Y. Zhang, J. Chang, O. Fatunde, Y. Arriaga, A.E. Frankel, S. Kalva, S. Zhang, T. McKenzie, O. Reig Torras, R.A. Figlin, B.I. Rini, R.M. McKay, P. Kapur, T. Wang, I. Pedrosa, and J. Brugarolas, HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor, in Patients with Clear Cell Renal Cell Carcinoma. Clinical Cancer Research, 2020. 26(4): p. 793-803.
  190. Esparza, M., A. Mor, H. Niederstrasser, K. White, A. White, K. Zhang, S. Gao, J. Wang, J. Liang, S. Sho, R. Sakthivel, A.A. Sathe, C. Xing, R. Muñoz-Moreno, J.W. Shay, A. García-Sastre, J. Ready, B. Posner, and B.M.A. Fontoura, Chemical intervention of influenza virus mRNA nuclear export. PLOS Pathogens, 2020. 16(4): p. e1008407.
  191. Fernández, Á.F., Y. Liu, V. Ginet, M. Shi, J. Nah, Z. Zou, A. Zhou, B.A. Posner, G. Xiao, M. Tanguy, V. Paradis, J. Sadoshima, P.-E. Rautou, J. Puyal, M.C. Hu, and B. Levine, Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia. JCI Insight, 2020. 5(1): p. 1 - 13.
  192. Jung, H., T. Takeshima, T. Nakagawa, K.S. MacMillan, R.M. Wynn, H. Wang, H. Sakiyama, S. Wei, Y. Li, R.K. Bruick, B.A. Posner, J.K. De Brabander, and K. Uyeda, The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP–importin α interactions. Biochemical Journal, 2020. 477(17): p. 3253-3269.
  193. Kokkonda, S., X. Deng, K.L. White, F. El Mazouni, J. White, D.M. Shackleford, K. Katneni, F.C.K. Chiu, H. Barker, J. McLaren, E. Crighton, G. Chen, I. Angulo-Barturen, M.B. Jimenez-Diaz, S. Ferrer, L. Huertas-Valentin, M.S. Martinez-Martinez, M.J. Lafuente-Monasterio, R. Chittimalla, S.P. Shahi, S. Wittlin, D. Waterson, J.N. Burrows, D. Matthews, D. Tomchick, P.K. Rathod, M.J. Palmer, S.A. Charman, and M.A. Phillips, Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria. Journal of Medicinal Chemistry, 2020. 63(9): p. 4929-4956.
  194. Layeghi-Ghalehsoukhteh, S., S. Pal Choudhuri, O. Ocal, Y. Zolghadri, V. Pashkov, H. Niederstrasser, B.A. Posner, H.S. Kantheti, A.C. Azevedo-Pouly, H. Huang, L. Girard, R.J. MacDonald, R.A. Brekken, and T.M. Wilkie, Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics. Scientific Reports, 2020. 10(1): p. 20662.
  195. Madhusudhan, N., B. Hu, P. Mishra, J.F. Calva-Moreno, K. Patel, R. Boriack, J.M. Ready, and D. Nijhawan, Target Discovery of Selective Non-Small-Cell Lung Cancer Toxins Reveals Inhibitors of Mitochondrial Complex I. ACS Chemical Biology, 2020. 15(1): p. 158-170.
  196. Povedano, J.M., R. Rallabandi, X. Bai, X. Ye, J. Liou, H. Chen, J. Kim, Y. Xie, B. Posner, L. Rice, J.K. De Brabander, and D.G. McFadden, A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins. Journal of Medicinal Chemistry, 2020. 63(22): p. 14054-14066.
  197. Ramadurgum, P., D.R. Woodard, S. Daniel, H. Peng, P.L. Mallipeddi, H. Niederstrasser, M. Mihelakis, V.Q. Chau, P.M. Douglas, B.A. Posner, and J.D. Hulleman, Simultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological Chaperones. Cell Chemical Biology, 2020. 27(5): p. 622-634.e6.
  198. Shen, Q., H. Niederstrasser, R. Barakat, Z. Haddadin, S.R. Miller, B. Posner, and Y.-T. Kim, Single-cell-level screening method for migratory cancer cells and its potential feasibility in high-throughput manner. Biofabrication, 2020. 12(3): p. 035019.
  199. Theodoropoulos, P.C., W. Wang, A. Budhipramono, B.M. Thompson, N. Madhusudhan, M.A. Mitsche, J.G. McDonald, J.K. De Brabander, and D. Nijhawan, A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins. Journal of the American Chemical Society, 2020. 142(13): p. 6128-6138.
  200. Ullah, I., S. Gahalawat, L.M. Booshehri, H. Niederstrasser, S. Majumdar, C. Leija, J.M. Bradford, B. Hu, J.M. Ready, and D.M. Wetzel, An Antiparasitic Compound from the Medicines for Malaria Venture Pathogen Box Promotes Leishmania Tubulin Polymerization. ACS Infectious Diseases, 2020. 6(8): p. 2057-2072.
  201. Williams, N.S., S. Gonzales, J. Naidoo, G. Rivera-Cancel, S. Voruganti, P. Mallipeddi, P.C. Theodoropoulos, S. Geboers, H. Chen, F. Ortiz, B. Posner, D. Nijhawan, and J.M. Ready, Tumor-Activated Benzothiazole Inhibitors of Stearoyl-CoA Desaturase. Journal of Medicinal Chemistry, 2020. 63(17): p. 9773-9786.
  202. Fontoura, B., M.A. Esparza, H. Niederstrasser, B. Posner, J.M. Ready, and A. Mor, High throughput drug screening methods for identifying inhibitors of viral M mRNA nuclear export and uses thereof for treating influenza viral infection. 2021, The Board of Regents of the University of Texas System, USA: U.S.A.
  203. Jaykumar, A.B., J.-U. Jung, P.K. Parida, T.T. Dang, C. Wichaidit, A.R. Kannangara, S. Earnest, E.J. Goldsmith, G.W. Pearson, S. Malladi, and M.H. Cobb, WNK1 Enhances Migration and Invasion in Breast Cancer Models. Molecular Cancer Therapeutics, 2021. 20(10): p. 1800-1808.
  204. Lawong, A., S. Gahalawat, J. Okombo, J. Striepen, T. Yeo, S. Mok, I. Deni, J.L. Bridgford, H. Niederstrasser, A. Zhou, B. Posner, S. Wittlin, F.J. Gamo, B. Crespo, A. Churchyard, J. Baum, N. Mittal, E. Winzeler, B. Laleu, M.J. Palmer, S.A. Charman, D.A. Fidock, J.M. Ready, and M.A. Phillips, Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum. Journal of Medicinal Chemistry, 2021. 64(5): p. 2739-2761.
  205. Lee, G., S. Karunanithi, B. Posner, H. Niederstrasser, H. Cheng, Y. Federov, S. Manjappa, K. Musaitif, H. Wang, Z. Jackson, and D. Wald, Chemical screening identifies novel small molecule activators of natural killer cell cytotoxicity against cancer cells. Cancer Immunology, Immunotherapy, 2021.
  206. Mallipeddi, P.L., Y. Zhang, H. Li, S.D. Markowitz, and B. Posner, Structural Insights into Novel 15-Prostaglandin Dehydrogenase Inhibitors. Molecules, 2021. 26(19): p. 5903.
  207. Palmer, M.J., X. Deng, S. Watts, G. Krilov, A. Gerasyuto, S. Kokkonda, F. El Mazouni, J. White, K.L. White, J. Striepen, J. Bath, K.A. Schindler, T. Yeo, D.M. Shackleford, S. Mok, I. Deni, A. Lawong, A. Huang, G. Chen, W. Wang, J. Jayaseelan, K. Katneni, R. Patil, J. Saunders, S.P. Shahi, R. Chittimalla, I. Angulo-Barturen, M.B. Jiménez-Díaz, S. Wittlin, P.K. Tumwebaze, P.J. Rosenthal, R.A. Cooper, A.C.C. Aguiar, R.V.C. Guido, D.B. Pereira, N. Mittal, E.A. Winzeler, D.R. Tomchick, B. Laleu, J.N. Burrows, P.K. Rathod, D.A. Fidock, S.A. Charman, and M.A. Phillips, Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. Journal of Medicinal Chemistry, 2021. 64(9): p. 6085-6136.
  208. Singh, S., W. Quarni, M. Goralski, S. Wan, H. Jin, L.-A.V.d. Velde, J. Fang, Q. Wu, A. Abu-Zaid, T. Wang, R. Singh, D. Craft, Y. Fan, T. Confer, M. Johnson, W.J. Akers, R. Wang, P.J. Murray, P.G. Thomas, D. Nijhawan, A.M. Davidoff, and J. Yang, Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Science Advances, 2021. 7(47): p. eabj5405.
  209. Smith, J.N.P., D.M. Dawson, K.F. Christo, A.P. Jogasuria, M.J. Cameron, M.I. Antczak, J.M. Ready, S.L. Gerson, S.D. Markowitz, and A.B. Desai, 15-PGDH inhibition activates the splenic niche to promote hematopoietic regeneration. JCI Insight, 2021. 6(6).
  210. WETZEL, D.M., I. ULLAH, L.M. BOOSHEHRI, J. READY, S. GAHALAWAT, B. HU, and Y. ADDEPALLI, NOVEL ANTIPARASITIC COMPOUNDS AND METHODS. 2021, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM.
  211. White, K., M. Esparza, J. Liang, P. Bhat, J. Naidoo, B.L. McGovern, M.A.P. Williams, B.R. Alabi, J. Shay, H. Niederstrasser, B. Posner, A. García-Sastre, J. Ready, and B.M.A. Fontoura, Aryl Sulfonamide Inhibits Entry and Replication of Diverse Influenza Viruses via the Hemagglutinin Protein. Journal of Medicinal Chemistry, 2021. 64(15): p. 10951-10966.
  212. Zhang, Z., S. Ray, L. Imlay, L.T. Callaghan, H. Niederstrasser, P.L. Mallipeddi, B.A. Posner, D.M. Wetzel, M.A. Phillips, and M.W. Smith, Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity. Chemical Science, 2021. 12(30): p. 10388-10394.
  213. Udden, S.N., Q. Wang, S. Kumar, V.S. Malladi, S.-Y. Wu, S. Wei, B.A. Posner, S. Geboers, N.S. Williams, Y.-L. Liu, J.K. Sharma, R.S. Mani, S. Malladi, K. Parra, M. Hofstad, G.V. Raj, J.M. Larios, R. Jagsi, M.S. Wicha, B.H. Park, G.P. Gupta, A.M. Chinnaiyan, C.-M. Chiang, and P.G. Alluri, Targeting ESR1 mutation-Induced transcriptional addiction in breast cancer with BET inhibition. JCI Insight, 2022.
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