2025 Article Archive
Experimental depression treatment preserves cognitive function
An experimental treatment for depression that triggers seizures with magnets significantly improved mental health in patients without some cognitive effects associated with electroconvulsive therapy (ECT), a clinical trial led by UT Southwestern Medical Center researchers showed.
Study implicates another gene in brain that causes weight gain
Mutations in a gene called OTP cause obesity by controlling the output of another gene already targeted by an anti-obesity drug, a study led by UT Southwestern Medical Center researchers shows.
UT Southwestern pharmacologists earn Hill Prize from TAMEST
David Mangelsdorf, Ph.D., Chair and Professor of Pharmacology and Professor of Biochemistry at UT Southwestern Medical Center, has been awarded the Hill Prize in Biological Sciences from the Texas Academy of Medicine, Engineering, Science and Technology (TAMEST) in recognition of his long-standing research on orphan nuclear receptors – proteins in the cell nucleus that flip genes on and off and are triggered by unknown molecules.
Autoimmune skin condition linked to higher risk of heart disease
Patients with cutaneous lupus erythematosus (CLE), an autoimmune disease that causes skin inflammation, have a higher risk for atherosclerotic cardiovascular disease (ASCVD), or hardening of the arteries, UT Southwestern Medical Center researchers found.
End-of-life care more aggressive for cancer patients with defibrillators
Patients with advanced cancer who also had cardiac defibrillators were more likely than those without these implants to receive aggressive end-of-life care, a team led by UT Southwestern Medical Center researchers found in a new study.
How sex and age shape fat patterns in muscles and bones
Researchers at UT Southwestern Medical Center have discovered sex-specific differences in how fat accumulates in muscle and bone, uncovering patterns that could inform new approaches to treating age-related diseases.
Stimulating fat cells with GIP receptor has potential to treat obesity
Obese mice whose fat cells were genetically altered to produce an increased amount of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lost more than a third of their body weight through a mechanism that burns energy, UT Southwestern Medical Center researchers report in a new study.
‘Good’ cholesterol may protect against brain atrophy, dementia
High-density lipoprotein (HDL), or “good” cholesterol, may play a vital role in conserving healthy brain matter in middle-aged adults, UT Southwestern Medical Center researchers report.