2024 Article Archive
UTSW Research: Female sex hormones, adrenal hyperplasia, and more
For decades, researchers have assumed that women taking oral contraceptives have stable levels of sex hormones over each monthly cycle. However, a new study in the American Journal of Physiology-Endocrinology and Metabolism led by Yasin Dhaher, Ph.D., Professor of Physical Medicine & Rehabilitation and Orthopaedic Surgery at UT Southwestern Medical Center, shows that the opposite is true.
Postpartum urinary incontinence linked to mental health
A UT Southwestern Medical Center study of hundreds of underserved women showed that depression and anxiety, in addition to physical factors such as a higher body mass index and previous births, are associated with lingering postpartum urinary incontinence. The findings, published in Urogynecology, shine a spotlight on these conditions that can carry stigmas but are largely treatable, researchers say.
Gene-editing nanoparticles correct stem cell mutations in cystic fibrosis models
Researchers at UT Southwestern Medical Center developed nanoparticles that successfully edited the disease-causing gene in the lungs of a mouse model of cystic fibrosis (CF), swapping a mutated form for a healthy one that persisted in stem cells. Their findings, reported in Science, could offer hope for people with CF and other debilitating genetic lung diseases.
Electroconvulsive therapy or ketamine? Clinical factors affect outcomes
Patients with moderate to severe treatment-resistant depression (TRD) might have better symptom relief from ketamine infusions than from electroconvulsive therapy (ECT), but those with severe TRD could benefit more from ECT early in treatment, an analysis led by a UT Southwestern Medical Center researcher shows.
Semaglutide lowers cardiovascular risk regardless of blood sugar
A weekly dose of semaglutide significantly reduced the risk of major adverse cardiovascular events (MACEs) in people who are overweight or obese with cardiovascular disease but no diabetes regardless of blood sugar level, according to a clinical trial including researchers from UT Southwestern Medical Center.
Diagnosing essential tremor after death helps families learn risk
A statistical tool designed to analyze 11 characteristics of postmortem brains reliably diagnosed a common neurodegenerative disease known as essential tremor (ET), a study led by researchers at UT Southwestern Medical Center and Columbia University shows.
Experts call for more clinical trials on alcohol use, liver disease
More clinical research is needed to investigate how reducing alcohol consumption in patients with alcohol-related liver disease (ALD) may slow disease progression and improve outcomes, according to an international task force of experts from more than two dozen institutions including UT Southwestern Medical Center.
Research could lead to treatments for obesity, extreme weight loss
Mysterious cells that secrete hormones in the large intestine play a key role in regulating body weight through their relationship with intestinal bacteria, a study led by UT Southwestern Medical Center researchers suggests. Their findings, published in Nature Metabolism, could lead to new treatments for obesity and extreme weight loss.
AccessHope, UT Southwestern Medical Center collaborate to expand cancer expertise access in southern states
– AccessHope, LLC, a company changing the way leading-edge cancer expertise is delivered, announced that UT Southwestern Harold C. Simmons Comprehensive Cancer Center will become the seventh National Cancer Institute (NCI)-designated center in the AccessHope network.
Study reveals unexpected mechanism of drug resistance in kidney cancer
For nearly two decades, how kidney cancer becomes resistant to rapalog drugs has baffled the scientific community. Now a study by researchers at UT Southwestern Medical Center’s Kidney Cancer Program sheds light.