New cardiovascular risk calculator offers precision medicine for people in midlife

DALLAS – July 30, 2018 – A team of researchers led by cardiologists at UT Southwestern Medical Center has developed a new online tool to more accurately predict who among those ages 40-65 is at the highest risk of suffering a heart attack or stroke in the next 10 years.

Measuring coronary artery calcium is among the most powerful and novel cardiovascular risk assessment tests. Until now, patients could not easily combine this measurement with traditional risk factors like blood pressure and cholesterol to predict the risk of having a stroke or heart attack. The new tool, named the Astronaut Cardiovascular Health and Risk Modification (Astro-CHARM) calculator, was developed by the National Space Biomedical Research Institute (NSBRI) together with a research team led by UT Southwestern preventive cardiologist Dr. Amit Khera. Its purpose is to facilitate precise cardiovascular risk assessment for astronauts as well as the general population.

Dr. Amit Khera is Professor of Internal Medicine and Director of UT Southwestern’s Preventive Cardiology Program.

“We found that the Astro-CHARM tool significantly improves cardiovascular risk prediction. It will be an important step forward in decision-making for preventive treatments in the general population for people in midlife,” said first author Dr. Khera, Professor of Internal Medicine and Director of UT Southwestern’s Preventive Cardiology Program, who holds the Dallas Heart Ball Chair in Hypertension and Heart Disease. “Cardiovascular risk assessment can also be critical in younger populations, particularly those in high-risk occupations.”

NASA launched the study with UT Southwestern to enhance cardiovascular risk prediction for astronauts, who are predominantly middle-aged men and women.

The full study on Astro-CHARM was recently published in the journal Circulation. The Astro-CHARM cardiovascular disease prevention tool can be found at astrocharm.org.

According to the Centers for Disease Control and Prevention, heart disease is the leading cause of death for both men and women. About 610,000 people die of heart disease in the United States every year, and many suffer complications from heart attack and stroke.

“This study is a perfect example of how NASA (and NSBRI) sponsored research helps both astronauts and the general population on Earth. The study was inspired by a critical question asked by flight surgeons and answered quickly by a partnership with academia,” said senior author and renowned UT Southwestern sports cardiologist Dr. Benjamin Levine.

Dr. Levine is Director of the Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, and a Professor of Internal Medicine/Cardiology at UT Southwestern, where he holds the Distinguished Professorship in Exercise Sciences.

For this study, the following risk factors were self-reported: race/ethnicity, history of cardiovascular diseases, medication usage, family history of myocardial infarction, and smoking status. Height, weight, blood pressure, plasma lipids, body mass index (BMI), and glucose were measured using standard methods. The researchers also looked at the patients’ personal and/or family history of diabetes and myocardial infarction.

The heart attack and risk calculator was developed by UT Southwestern, NASA, and NSBRI.

The mean age of the 7,382 study participants was 51, and the group was 45 percent female and 55 percent nonwhite. Data for this study were pooled from the Multi-Ethnic Study of Atherosclerosis, the Dallas Heart Study, and the Prospective Army Coronary Calcium Project. It was independently validated with the Framingham Heart Study Offspring and Third Generation cohorts.

The Dallas Heart Study was initiated in 2000 with the primary goal of improving the diagnosis, prevention, and treatment of heart disease. It is the only single center heart study of its size and multiethnic composition. 

Other UT Southwestern researchers who contributed to this work include Dr. James de Lemos, Professor of Internal Medicine who holds the Sweetheart Ball-Kern Wildenthal, M.D., Ph.D. Distinguished Chair in Cardiology, and Dr. Colby A. Ayers, a Clinical Sciences faculty associate. Dr. de Lemos has disclosed receipt of grant support from Roche Diagnostics and Abbott Diagnostics; and his consulting work for Ortho Clinical Diagnostics, Roche Diagnostics, Abbott Diagnostics, the Endpoint Committee for Siemen’s Health Care Diagnostics and Radiometer, and a Steering Committee from Amgen.

UT Southwestern is celebrating its 75^th anniversary during 2018.

About UT Southwestern Medical Center

UT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institution’s faculty has received six Nobel Prizes, and includes 22 members of the National Academy of Sciences, 16 members of the National Academy of Medicine, and 15 Howard Hughes Medical Institute Investigators. The faculty of more than 2,700 is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide care in about 80 specialties to more than 100,000 hospitalized patients, 600,000 emergency room cases, and oversee approximately 2.2 million outpatient visits a year.