2023
Fernandes, L.M., Tresemer, J., Zhang, J., Rios, J.J., Scallan, J.P., Dellinger, M.T., Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function. Front Cell Dev Biol, 11: 1276333, 2023
Choudhuri, S.P., Girard, L., Lim, J.Y.S., Wise, J.F., Freitas, B., Yang, D., Wong, E., Hamilton, S., Chien, V.D., Gilbreath, C., Zhong, J., Phat, S., Myers, D.T., Christensen, C.L., Stanzione, M., Wong, K.K., Farago, A.F., Meador, C.B., Dyson, N.J., Lawrence, M.S., Wu, S., Drapkin, B.J., Acquired Cross-resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC paralogs. bioRxiv, 2023
Bhalla, S., Fattah, F.J., Ahn, C., Williams, J., Macchiaroli, A., Padro, J., Pogue, M., Dowell, J.E., Putnam, W.C., McCracken, N., Micklem, D., Brekken, R.A., Gerber, D.E., Phase 1 trial of bemcentinib (BGB324), a first-in-class, selective AXL inhibitor, with docetaxel in patients with previously treated advanced non-small cell lung cancer. Lung Cancer, 182: 107291, 2023
Qian, Y., Galan-Cobo, A., Guijarro, I., Dang, M., Molkentine, D., Poteete, A., Zhang, F., Wang, Q., Wang, J., Parra, E., Panda, A., Fang, J., Skoulidis, F., Wistuba, II, Verma, S., Merghoub, T., Wolchok, J.D., Wong, K.K., DeBerardinis, R.J., Minna, J.D., Vokes, N.I., Meador, C.B., Gainor, J.F., Wang, L., Reuben, A., Heymach, J.V., MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma. Cancer Cell, 41: 1363-1380 e7, 2023
Kwok, H.H., Li, H., Yang, J., Deng, J., Lee, N.C., Au, T.W., Sit, A.K., Hsin, M.K., Ma, S.K., Cheung, L.W., Girard, L., Fujimoto, J., Wistuba, II, Gao, B., Minna, J.D., Lam, D.C., Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma. Cancer Commun (Lond), 43: 951-955, 2023
Cai, L., DeBerardinis, R.J., Xie, Y., Minna, J.D., Xiao, G., A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma. Mol Cancer Res: OF1-OF13, 2023
Shah, A.M., Guo, L., Morales, M.G., Jaichander, P., Chen, K., Huang, H., Cano Hernandez, K., Xu, L., Bassel-Duby, R., Olson, E.N., Liu, N., TWIST2-mediated chromatin remodeling promotes fusion-negative rhabdomyosarcoma. Sci Adv, 9: eade8184, 2023
Iyengar, P., Gandhi, A.Y., Granados, J., Guo, T., Gupta, A., Yu, J., Llano, E.M., Zhang, F., Gao, A., Kandathil, A., Williams, D., Gao, B., Girard, L., Malladi, V.S., Shelton, J.M., Evers, B.M., Hannan, R., Ahn, C., Minna, J.D., Infante, R.E., Tumor loss-of-function mutations in STK11/LKB1 induce cachexia. JCI Insight, 8, 2023
Huffman, K.E., Li, L.S., Carstens, R., Park, H., Girard, L., Avila, K., Wei, S., Kollipara, R., Timmons, B., Sudderth, J., Bendris, N., Kim, J., Villalobos, P., Fujimoto, J., Schmid, S., Deberardinis, R.J., Wistuba, I., Heymach, J., Kittler, R., Akbay, E.A., Posner, B., Wang, Y., Lam, S., Kliewer, S.A., Mangelsdorf, D.J., Minna, J.D., Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers. Front Oncol, 13: 1025443, 2023
Ganguly, D., Schmidt, M.O., Coleman, M., Ngo, T.C., Sorrelle, N., Dominguez, A.T.A., Murimwa, G.Z., Toombs, J.E., Lewis, C., Fang, Y.V., Valdes-Mora, F., Gallego-Ortega, D., Wellstein, A., Brekken, R.A., Pleiotrophin drives a prometastatic immune niche in breast cancer. J Exp Med, 220, 2023
Kim, J., Minna, J.D., Moving toward precision medicine with lung cancer organoids. Cell Rep Med, 4: 100952, 2023
Nilsson, M.B., Yang, Y., Heeke, S., Patel, S.A., Poteete, A., Udagawa, H., Elamin, Y.Y., Moran, C.A., Kashima, Y., Arumugam, T., Yu, X., Ren, X., Diao, L., Shen, L., Wang, Q., Zhang, M., Robichaux, J.P., Shi, C., Pfeil, A.N., Tran, H., Gibbons, D.L., Bock, J., Wang, J., Minna, J.D., Kobayashi, S.S., Le, X., Heymach, J.V., CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance. Cancer Cell, 41: 340-355 e6, 2023
Wang, S., Rong, R., Yang, D.M., Fujimoto, J., Bishop, J.A., Yan, S., Cai, L., Behrens, C., Berry, L.D., Wilhelm, C., Aisner, D., Sholl, L., Johnson, B.E., Kwiatkowski, D.J., Wistuba, II, Bunn, P.A., Jr., Minna, J., Xiao, G., Kris, M.G., Xie, Y., Features of tumor-microenvironment images predict targeted therapy survival benefit in patients with EGFR-mutant lung cancer. J Clin Invest, 133, 2023
Duan, L., Chen, Y.A., Liang, Y., Chen, Z., Lu, J., Fang, Y., Cao, J., Lu, J., Zhao, H., Pong, R.C., Hernandez, E., Kapur, P., Tran, T.A.T., Smith, T., Martinez, E.D., Ahn, J.M., Hsieh, J.T., Luo, J.H., Liu, Z.P., Therapeutic targeting of histone lysine demethylase KDM4B blocks the growth of castration-resistant prostate cancer. Biomed Pharmacother, 158: 114077, 2023
2022
Pongor, L.S., Tlemsani, C., Elloumi, F., Arakawa, Y., Jo, U., Gross, J.M., Mosavarpour, S., Varma, S., Kollipara, R.K., Roper, N., Teicher, B.A., Aladjem, M.I., Reinhold, W., Thomas, A., Minna, J.D., Johnson, J.E., Pommier, Y., Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation. iScience, 25: 105338, 2022
Cruz-Lorenzo, E., Ramirez, N.P., Lee, J., Pandhe, S., Wang, L., Hernandez-Doria, J., Spivak, A.M., Planelles, V., Petersen, T., Jain, M.K., Martinez, E.D., D'Orso, I., Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity. Viruses, 14, 2022
Dixit, A., Sarver, A., Zettervall, J., Huang, H., Zheng, K., Brekken, R.A., Provenzano, P.P., Targeting TNF-alpha-producing macrophages activates antitumor immunity in pancreatic cancer via IL-33 signaling. JCI Insight, 7, 2022
Kim, K., Huang, H., Parida, P.K., He, L., Marquez-Palencia, M., Reese, T.C., Kapur, P., Brugarolas, J., Brekken, R.A., Malladi, S., Cell Competition Shapes Metastatic Latency and Relapse. Cancer Discov, 13: 85-97, 2023
von Itzstein, M.S., Gerber, D.E., Minna, J.D., Circulating mitochondrial DNA as a biomarker for lung cancer screening. Transl Lung Cancer Res, 11: 1522-1525, 2022
Cai, L., DeBerardinis, R.J., Xiao, G., Minna, J.D., Xie, Y., A Pan-Cancer Assessment of RB1/TP53 Co-Mutations. Cancers (Basel), 14, 2022
Suchors, C., Kim, J., Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer. Cells, 11, 2022
Krebs, N., Klein, L., Wegwitz, F., Espinet, E., Maurer, H.C., Tu, M., Penz, F., Kuffer, S., Xu, X., Bohnenberger, H., Cameron, S., Brunner, M., Neesse, A., Kishore, U., Hessmann, E., Trumpp, A., Strobel, P., Brekken, R.A., Ellenrieder, V., Singh, S.K., Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer. JCI Insight, 7, 2022
Sanidas, I., Lee, H., Rumde, P.H., Boulay, G., Morris, R., Golczer, G., Stanzione, M., Hajizadeh, S., Zhong, J., Ryan, M.B., Corcoran, R.B., Drapkin, B.J., Rivera, M.N., Dyson, N.J., Lawrence, M.S., Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression. Mol Cell, 82: 3333-3349 e9, 2022
Elamir, A.M., Karalis, J.D., Sanford, N.N., Polanco, P.M., Folkert, M.R., Porembka, M.R., Kazmi, S.A., Maddipati, R., Zeh, H.J., Timmerman, R.D., Zhang, S., Ligorio, M., Beg, M.S., Aguilera, T.A., Ablative Radiation Therapy in Oligometastatic Pancreatic Cancer to Delay Polyprogression, Limit Chemotherapy, and Improve Outcomes. Int J Radiat Oncol Biol Phys, 114: 792-802, 2022
Bartolacci, C., Andreani, C., Vale, G., Berto, S., Melegari, M., Crouch, A.C., Baluya, D.L., Kemble, G., Hodges, K., Starrett, J., Politi, K., Starnes, S.L., Lorenzini, D., Raso, M.G., Solis Soto, L.M., Behrens, C., Kadara, H., Gao, B., Wistuba, II, Minna, J.D., McDonald, J.G., Scaglioni, P.P., Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer. Nat Commun, 13: 4327, 2022
Han, J.H., Kim, Y.K., Kim, H., Lee, J., Oh, M.J., Kim, S.B., Kim, M., Kim, K.H., Yoon, H.J., Lee, M.S., Minna, J.D., White, M.A., Kim, H.S., Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells. Cancer Commun (Lond), 42: 716-749, 2022
Park, J.V., Chandra, R., Cai, L., Ganguly, D., Li, H., Toombs, J.E., Girard, L., Brekken, R.A., Minna, J.D., Tumor Cells Modulate Macrophage Phenotype in a Novel In Vitro Co-Culture Model of the NSCLC Tumor Microenvironment. J Thorac Oncol, 17: 1178-1191, 2022
Mack, P.C., Hirsch, F.R., Bunn, P.A., Minna, J.D., Longitudinal Analyses of COVID-19 Vaccination in Patients With Lung Cancer: Antibody Responses and Variant-Specific Neutralization. J Clin Oncol, 40: 3787-3789, 2022
Stanzione, M., Zhong, J., Wong, E., LaSalle, T.J., Wise, J.F., Simoneau, A., Myers, D.T., Phat, S., Sade-Feldman, M., Lawrence, M.S., Hadden, M.K., Zou, L., Farago, A.F., Dyson, N.J., Drapkin, B.J., Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer. Sci Adv, 8: eabn1229, 2022
Huang, H., Wang, Z., Zhang, Y., Pradhan, R.N., Ganguly, D., Chandra, R., Murimwa, G., Wright, S., Gu, X., Maddipati, R., Muller, S., Turley, S.J., Brekken, R.A., Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer. Cancer Cell, 40: 656-673 e7, 2022
Mack, P.C., Gomez, J.E., Rodilla, A.M., Carreno, J.M., Hsu, C.Y., Rolfo, C., Meshulami, N., Moore, A., Brody, R.I., King, J.C., Treatman, J., Lee, S., Raskin, A., Srivastava, K., Gleason, C.R., de Miguel-Perez, D., group, P.P.s., Tcheou, J., Bielak, D., Acharya, R., Gerber, D.E., Rohs, N., Henschke, C.I., Yankelevitz, D.F., Simon, V., Minna, J.D., Bunn, P.A., Jr., Garcia-Sastre, A., Krammer, F., Shyr, Y., Hirsch, F.R., Longitudinal COVID-19-vaccination-induced antibody responses and Omicron neutralization in patients with lung cancer. Cancer Cell, 40: 575-577, 2022
Li, H., Liu, Z., Liu, L., Zhang, H., Han, C., Girard, L., Park, H., Zhang, A., Dong, C., Ye, J., Rayford, A., Peyton, M., Li, X., Avila, K., Cao, X., Hu, S., Alam, M.M., Akbay, E.A., Solis, L.M., Behrens, C., Hernandez-Ruiz, S., Lu, W., Wistuba, I., Heymach, J.V., Chisamore, M., Micklem, D., Gabra, H., Gausdal, G., Lorens, J.B., Li, B., Fu, Y.X., Minna, J.D., Brekken, R.A., AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1(+) CD8 T cells. Cell Rep Med, 3: 100554, 2022
Zhang, Y., Brekken, R.A., Direct and indirect regulation of the tumor immune microenvironment by VEGF. J Leukoc Biol, 111: 1269-1286, 2022
Kim, Y., Lee, S., Cho, S., Park, J., Chae, D., Park, T., Minna, J.D., Kim, H.H., High-throughput functional evaluation of human cancer-associated mutations using base editors. Nat Biotechnol, 40: 874-884, 2022
Zhang, Y., Brekken, R.A., Are TEMs Canceled? Questioning the Functional Relevance of Tie2-Expressing Macrophages. Cancer Res, 82: 1172-1173, 2022
Osborne, J.K., Minna, J.D., Lung Cancer Cell of Origin: Controversy and Clinical Translational Implications. Cancer Res, 82: 972-973, 2022
Shukla, S.P., Zhang, H., Fang, B., Minna, J.D., Gomika Udugamasooriya, D., Unbiased peptoid cell screen identifies a peptoid targeting newly appeared cell surface vimentin on tumor transformed early lung cancer cells. Bioorg Med Chem, 58: 116673, 2022
Muraki, N., Yamada, M., Doki, H., Nakai, R., Komeda, K., Goto, D., Kawabe, N., Matsuoka, K., Matsushima, M., Kawabe, T., Tanaka, I., Morise, M., Shay, J.W., Minna, J.D., Sato, M., Resistance to mutant KRAS(V12)-induced senescence in an hTERT/Cdk4-immortalized normal human bronchial epithelial cell line. Exp Cell Res, 414: 113053, 2022
Kim, J., Minna, J.D., AP-1 leads the way in lung cancer transformation. Dev Cell, 57: 292-294, 2022
Ha, Y.J., Oh, M.J., Kim, J., Kim, J., Kang, S., Minna, J.D., Kim, H.S., Kim, S., Establishment of reference standards for multifaceted mosaic variant analysis. Sci Data, 9: 35, 2022
Son, J., Huang, S., Zeng, Q., Bricker, T.L., Case, J.B., Zhou, J., Zang, R., Liu, Z., Chang, X., Darling, T.L., Xu, J., Harastani, H.H., Chen, L., Gomez Castro, M.F., Zhao, Y., Kohio, H.P., Hou, G., Fan, B., Niu, B., Guo, R., Rothlauf, P.W., Bailey, A.L., Wang, X., Shi, P.Y., Martinez, E.D., Brody, S.L., Whelan, S.P.J., Diamond, M.S., Boon, A.C.M., Li, B., Ding, S., JIB-04 Has Broad-Spectrum Antiviral Activity and Inhibits SARS-CoV-2 Replication and Coronavirus Pathogenesis. mBio, 13: e0337721, 2022
Tran, T.A., Zhang, Q.J., Wang, L., Gonzales, C., Girard, L., May, H., Gillette, T., Liu, Z.P., Martinez, E.D., Inhibition of Jumonji demethylases reprograms severe dilated cardiomyopathy and prolongs survival. J Biol Chem, 298: 101515, 2022
Rolfo, C., Meshulami, N., Russo, A., Krammer, F., Garcia-Sastre, A., Mack, P.C., Gomez, J.E., Bhardwaj, N., Benyounes, A., Sirera, R., Moore, A., Rohs, N., Henschke, C.I., Yankelevitz, D., King, J., Shyr, Y., Bunn, P.A., Jr., Minna, J.D., Hirsch, F.R., Lung Cancer and Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Identifying Important Knowledge Gaps for Investigation. J Thorac Oncol, 17: 214-227, 2022
Cai, L., Xiao, G., Gerber, D., J, D.M., Xie, Y., Lung Cancer Computational Biology and Resources. Cold Spring Harb Perspect Med, 12, 2022
Zhang, Y., Arner, E.N., Rizvi, A., Toombs, J.E., Huang, H., Warner, S.L., Foulks, J.M., Brekken, R.A., AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer. Mol Cancer Ther, 21: 38-47, 2022
Galan-Cobo, A., Stellrecht, C.M., Yilmaz, E., Yang, C., Qian, Y., Qu, X., Akhter, I., Ayres, M.L., Fan, Y., Tong, P., Diao, L., Ding, J., Giri, U., Gudikote, J., Nilsson, M., Wierda, W.G., Wang, J., Skoulidis, F., Minna, J.D., Gandhi, V., Heymach, J.V., Enhanced Vulnerability of LKB1-Deficient NSCLC to Disruption of ATP Pools and Redox Homeostasis by 8-Cl-Ado. Mol Cancer Res, 20: 280-292, 2022
Wilson, A.N., Chen, B., Liu, X., Kurie, J.M., Kim, J., A Method for Orthotopic Transplantation of Lung Cancer in Mice. Methods Mol Biol, 2374: 231-242, 2022
Maddipati, R., Norgard, R.J., Baslan, T., Rathi, K.S., Zhang, A., Saeid, A., Higashihara, T., Wu, F., Kumar, A., Annamalai, V., Bhattacharya, S., Raman, P., Adkisson, C.A., Pitarresi, J.R., Wengyn, M.D., Yamazoe, T., Li, J., Balli, D., LaRiviere, M.J., Ngo, T.C., Folkert, I.W., Millstein, I.D., Bermeo, J., Carpenter, E.L., McAuliffe, J.C., Oktay, M.H., Brekken, R.A., Lowe, S.W., Iacobuzio-Donahue, C.A., Notta, F., Stanger, B.Z., MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma. Cancer Discov, 12: 542-561, 2022
2021
Wörmann, S.M., Zhang, A., Thege, F.I., Cowan, R.W., Rupani, D.N., Wang, R., Manning, S.L., Gates, C., Wu, W., Levin-Klein, R., Rajapakshe, K.I., Yu, M., Multani, A.S., Kang, Y., Taniguchi, C.M., Schlacher, K., Bellin, M.D., Katz, M.H.G., Kim, M.P., Fleming, J.B., Gallinger, S., Maddipati, R., Harris, R.S., Notta, F., Ross, S.R., Maitra, A., Rhim, A.D., APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis. Nat Cancer, 2: 1338-1356, 2021
Malik, S., Westcott, J.M., Brekken, R.A., Burrows, F.J., CXCL12 in Pancreatic Cancer: Its Function and Potential as a Therapeutic Drug Target. Cancers (Basel), 14, 2021
Chandra, R., Karalis, J.D., Liu, C., Murimwa, G.Z., Voth Park, J., Heid, C.A., Reznik, S.I., Huang, E., Minna, J.D., Brekken, R.A., The Colorectal Cancer Tumor Microenvironment and Its Impact on Liver and Lung Metastasis. Cancers (Basel), 13, 2021
Gong, K., Guo, G., Beckley, N.A., Yang, X., Zhang, Y., Gerber, D.E., Minna, J.D., Burma, S., Zhao, D., Akbay, E.A., Habib, A.A., Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids. Nat Commun, 12: 7014, 2021
Bohan, D., Van Ert, H., Ruggio, N., Rogers, K.J., Badreddine, M., Aguilar Briseño, J.A., Elliff, J.M., Rojas Chavez, R.A., Gao, B., Stokowy, T., Christakou, E., Kursula, P., Micklem, D., Gausdal, G., Haim, H., Minna, J., Lorens, J.B., Maury, W., Phosphatidylserine receptors enhance SARS-CoV-2 infection. PLoS Pathog, 17: e1009743, 2021
Kwok, H.H., Gao, B., Chan, K.H., Ip, M.S., Minna, J.D., Lam, D.C., Nicotinic Acetylcholine Receptor Subunit α7 Mediates Cigarette Smoke-Induced PD-L1 Expression in Human Bronchial Epithelial Cells. Cancers (Basel), 13, 2021
Yenerall, P., Kittler, R., Minna, J., Structure-based classification of EGFR mutations informs inhibitor selection for lung cancer therapy. Cancer Cell, 39: 1455-1457, 2021
Cejas, P., Xie, Y., Font-Tello, A., Lim, K., Syamala, S., Qiu, X., Tewari, A.K., Shah, N., Nguyen, H.M., Patel, R.A., Brown, L., Coleman, I., Hackeng, W.M., Brosens, L., Dreijerink, K.M.A., Ellis, L., Alaiwi, S.A., Seo, J.H., Baca, S., Beltran, H., Khani, F., Pomerantz, M., Dall'Agnese, A., Crowdis, J., Van Allen, E.M., Bellmunt, J., Morrisey, C., Nelson, P.S., DeCaprio, J., Farago, A., Dyson, N., Drapkin, B., Liu, X.S., Freedman, M., Haffner, M.C., Corey, E., Brown, M., Long, H.W., Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer. Nat Commun, 12: 5775, 2021
Huang, H., Brekken, R.A., Location Matters: Profiling Diffuse Type Gastric Cancer At the Single-Cell Level. Clin Cancer Res, 27: 6284-6286, 2021
Liu, H., Hiremath, C., Patterson, Q., Vora, S., Shang, Z., Jamieson, A.R., Fiolka, R., Dean, K.M., Dellinger, M.T., Marciano, D.K., Heterozygous Mutation of Vegfr3 Reduces Renal Lymphatics without Renal Dysfunction. J Am Soc Nephrol, 32: 3099-113, 2021
Pozo, K., Kollipara, R.K., Kelenis, D.P., Rodarte, K.E., Ullrich, M.S., Zhang, X., Minna, J.D., Johnson, J.E., ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer. iScience, 24: 102953, 2021
Rashdan, S., Iyengar, P., Minna, J.D., Gerber, D.E., Narrative review: molecular and genetic profiling of oligometastatic non-small cell lung cancer. Transl Lung Cancer Res, 10: 3351-3368, 2021
Yan, C., Yang, Q., Zhang, S., Millar, D.G., Alpert, E.J., Do, D., Veloso, A., Brunson, D.C., Drapkin, B.J., Stanzione, M., Scarfò, I., Moore, J.C., Iyer, S., Qin, Q., Wei, Y., McCarthy, K.M., Rawls, J.F., Dyson, N.J., Cobbold, M., Maus, M.V., Langenau, D.M., Single-cell imaging of T cell immunotherapy responses in vivo. J Exp Med, 218, 2021
Zhang, W., Bhagwath, A.S., Ramzan, Z., Williams, T.A., Subramaniyan, I., Edpuganti, V., Kallem, R.R., Dunbar, K.B., Ding, P., Gong, K., Geurkink, S.A., Beg, M.S., Kim, J., Zhang, Q., Habib, A.A., Choi, S.H., Lapsiwala, R., Bhagwath, G., Dowell, J.E., Melton, S.D., Jie, C., Putnam, W.C., Pham, T.H., Wang, D.H., Itraconazole Exerts Its Antitumor Effect in Esophageal Cancer By Suppressing the HER2/AKT Signaling Pathway. Mol Cancer Ther, 20: 1904-1915, 2021
Umfress, A., Speed, H.E., Tan, C., Ramezani, S., Birnbaum, S., Brekken, R.A., Sun, X., Plattner, F., Powell, C.M., Bibb, J.A., Neuropathological Effects of Chemotherapeutic Drugs. ACS Chem Neurosci, 12: 3038-3048, 2021
Zhang, A., Ren, Z., Tseng, K.F., Liu, X., Li, H., Lu, C., Cai, Y., Minna, J.D., Fu, Y.X., Dual targeting of CTLA-4 and CD47 on T(reg) cells promotes immunity against solid tumors. Sci Transl Med, 13, 2021
von Itzstein, M.S., Drapkin, B.J., Minna, J.D., How lung cancer cells change identity. Elife, 10, 2021
Norgard, R.J., Pitarresi, J.R., Maddipati, R., Aiello-Couzo, N.M., Balli, D., Li, J., Yamazoe, T., Wengyn, M.D., Millstein, I.D., Folkert, I.W., Rosario-Berrios, D.N., Kim, I.K., Bassett, J.B., Payne, R., Berry, C.T., Feng, X., Sun, K., Cioffi, M., Chakraborty, P., Jolly, M.K., Gutkind, J.S., Lyden, D., Freedman, B.D., Foskett, J.K., Rustgi, A.K., Stanger, B.Z., Calcium signaling induces a partial EMT. EMBO Rep, 22: e51872, 2021
Patel, S.A., Herynk, M.H., Cascone, T., Saigal, B., Nilsson, M.B., Tran, H., Ramachandran, S., Diao, L., Wang, J., Le, X., Minna, J., Wistuba, II, Heymach, J.V., Estrogen Promotes Resistance to Bevacizumab in Murine Models of NSCLC. J Thorac Oncol, 16: 2051-2064, 2021
Burckhardt, C.J., Minna, J.D., Danuser, G., Co-immunoprecipitation and semi-quantitative immunoblotting for the analysis of protein-protein interactions. STAR Protoc, 2: 100644, 2021
Stewart, C.A., Gay, C.M., Ramkumar, K., Cargill, K.R., Cardnell, R.J., Nilsson, M.B., Heeke, S., Park, E.M., Kundu, S.T., Diao, L., Wang, Q., Shen, L., Xi, Y., Zhang, B., Della Corte, C.M., Fan, Y., Kundu, K., Gao, B., Avila, K., Pickering, C.R., Johnson, F.M., Zhang, J., Kadara, H., Minna, J.D., Gibbons, D.L., Wang, J., Heymach, J.V., Byers, L.A., Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2-Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology. J Thorac Oncol, 16: 1821-1839, 2021
von Itzstein, M.S., Gerber, D.E., Minna, J.D., Contemporary Lung Cancer Screening and the Promise of Blood-Based Biomarkers. Cancer Res, 81: 3441-3443, 2021
Deng, J., Kang, Y., Cheng, C.C., Li, X., Dai, B., Katz, M.H., Men, T., Kim, M.P., Koay, E.A., Huang, H., Brekken, R.A., Fleming, J.B., DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis. JCI Insight, 6, 2021
Calianese, D., Kreiss, T., Kasikara, C., Davra, V., Lahey, K.C., Gadiyar, V., Geng, K., Singh, S., Honnen, W., Jaijyan, D.K., Reichman, C., Siekierka, J., Gennaro, M.L., Kotenko, S.V., Ucker, D.S., Brekken, R.A., Pinter, A., Birge, R.B., Choudhary, A., Phosphatidylserine-Targeting Monoclonal Antibodies Exhibit Distinct Biochemical and Cellular Effects on Anti-CD3/CD28-Stimulated T Cell IFN-γ and TNF-α Production. J Immunol, 207: 436-448, 2021
Zhang, Y., Coleman, M., Brekken, R.A., Perspectives on Hypoxia Signaling in Tumor Stroma. Cancers (Basel), 13, 2021 Homayun-Sepehr, N., McCarter, A.L., Helaers, R., Galant, C., Boon, L.M., Brouillard, P., Vikkula, M., Dellinger, M.T., KRAS-driven model of Gorham-Stout disease effectively treated with trametinib. JCI Insight, 6, 2021 Cai, L., Liu, H., Minna, J.D., DeBerardinis, R.J., Xiao, G., Xie, Y., Assessing Consistency Across Functional Screening Datasets in Cancer Cells. Bioinformatics, 37: 4540-7, 2021 Drapkin, B.J., Minna, J.D., A rational targeted therapy for platinum-resistant small-cell lung cancer. Cancer Cell, 39: 453-456, 2021
Vijay, R., Guthmiller, J.J., Sturtz, A.J., Crooks, S., Johnson, J.T., Li, L., Lan, L.Y., Pope, R.L., Chen, Y., Rogers, K.J., Dutta, N., Toombs, J.E., Wilson, M.E., Wilson, P.C., Maury, W., Brekken, R.A., Butler, N.S., Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiation. J Exp Med, 218, 2021
Du, W., Phinney, N.Z., Huang, H., Wang, Z., Westcott, J., Toombs, J.E., Zhang, Y., Beg, M.S., Wilkie, T.M., Lorens, J.B., Brekken, R.A., AXL Is a Key Factor for Cell Plasticity and Promotes Metastasis in Pancreatic Cancer. Mol Cancer Res, 19: 1412-1421, 2021
Han, G., Sinjab, A., Hara, K., Treekitkarnmongkol, W., Brennan, P., Chang, K., Bogatenkova, E., Sanchez-Espiridion, B., Behrens, C., Solis, L.M., Gao, B., Girard, L., Zhang, J., Sepesi, B., Cascone, T., Byers, L.A., Gibbons, D.L., Chen, J., Moghaddam, S.J., Ostrin, E.J., Scheet, P., Fujimoto, J., Shay, J., Heymach, J.V., Minna, J.D., Dubinett, S., Wistuba, II, Stevenson, C.S., Spira, A.E., Wang, L., Kadara, H., Single-Cell Expression Landscape of SARS-CoV-2 Receptor ACE2 and Host Proteases in Normal and Malignant Lung Tissues from Pulmonary Adenocarcinoma Patients. Cancers (Basel), 13, 2021
Driskill, J.H., Zheng, Y., Wu, B.K., Wang, L., Cai, J., Rakheja, D., Dellinger, M., Pan, D., WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma. Genes Dev, 35: 495-511, 2021
Burckhardt, C.J., Minna, J.D., Danuser, G., SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt. Dev Cell, 56: 1164-1181.e12, 2021
Cai, L., Liu, H., Huang, F., Fujimoto, J., Girard, L., Chen, J., Li, Y., Zhang, Y.A., Deb, D., Stastny, V., Pozo, K., Kuo, C.S., Jia, G., Yang, C., Zou, W., Alomar, A., Huffman, K., Papari-Zareei, M., Yang, L., Drapkin, B., Akbay, E.A., Shames, D.S., Wistuba, II, Wang, T., Johnson, J.E., Xiao, G., DeBerardinis, R.J., Minna, J.D., Xie, Y., Gazdar, A.F., Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer. Commun Biol, 4: 314, 2021
Khaliq, M., Manikkam, M., Martinez, E.D., Fallahi-Sichani, M., Epigenetic modulation reveals differentiation state specificity of oncogene addiction. Nat Commun, 12: 1536, 2021
Wogsland, C.E., Lien, H.E., Pedersen, L., Hanjra, P., Grondal, S.M., Brekken, R.A., Lorens, J.B., Halberg, N., High-dimensional immunotyping of tumors grown in obese and non-obese mice. Dis Model Mech, 14, 2021
Zhang, K., Miorin, L., Makio, T., Dehghan, I., Gao, S., Xie, Y., Zhong, H., Esparza, M., Kehrer, T., Kumar, A., Hobman, T.C., Ptak, C., Gao, B., Minna, J.D., Chen, Z., García-Sastre, A., Ren, Y., Wozniak, R.W., Fontoura, B.M.A., Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression. Sci Adv, 7, 2021
Yuan, G., Flores, N.M., Hausmann, S., Lofgren, S.M., Kharchenko, V., Angulo-Ibanez, M., Sengupta, D., Lu, X., Czaban, I., Azhibek, D., Vicent, S., Fischle, W., Jaremko, M., Fang, B., Wistuba, II, Chua, K.F., Roth, J.A., Minna, J.D., Shao, N.Y., Jaremko, Ł., Mazur, P.K., Gozani, O., Elevated NSD3 histone methylation activity drives squamous cell lung cancer. Nature, 590: 504-508, 2021
Zhu, M., Huang, Y., Bender, M.E., Girard, L., Kollipara, R., Eglenen-Polat, B., Naito, Y., Savage, T.K., Huffman, K.E., Koyama, S., Kumanogoh, A., Minna, J.D., Johnson, J.E., Akbay, E.A., Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis. Cancer Res, 81: 1813-1826, 2021
Gay, C.M., Stewart, C.A., Park, E.M., Diao, L., Groves, S.M., Heeke, S., Nabet, B.Y., Fujimoto, J., Solis, L.M., Lu, W., Xi, Y., Cardnell, R.J., Wang, Q., Fabbri, G., Cargill, K.R., Vokes, N.I., Ramkumar, K., Zhang, B., Della Corte, C.M., Robson, P., Swisher, S.G., Roth, J.A., Glisson, B.S., Shames, D.S., Wistuba, II, Wang, J., Quaranta, V., Minna, J., Heymach, J.V., Byers, L.A., Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities. Cancer Cell, 39: 346-360.e7, 2021
Liu, Y., Gao, G.F., Minna, J.D., Williams, N.S., Westover, K.D., Loss of wild type KRAS in KRAS(MUT) lung adenocarcinoma is associated with cancer mortality and confers sensitivity to FASN inhibitors. Lung Cancer, 153: 73-80, 2021
Thomas, P.L., Madubata, C.J., Aldrich, M.C., Lee, M.M., Owonikoko, T.K., Minna, J.D., Rudin, C.M., Sage, J., Lovly, C.M., A Call to Action: Dismantling Racial Injustices in Preclinical Research and Clinical Care of Black Patients Living with Small Cell Lung Cancer. Cancer Discov, 11: 240-244, 2021
Nilsson, M.B., Robichaux, J., Herynk, M.H., Cascone, T., Le, X., Elamin, Y., Patel, S., Zhang, F., Xu, L., Hu, L., Diao, L., Shen, L., He, J., Yu, X., Nikolinakos, P., Saintigny, P., Fang, B., Girard, L., Wang, J., Minna, J.D., Wistuba, II, Heymach, J.V., Altered Regulation of HIF-1α in Naive- and Drug-Resistant EGFR-Mutant NSCLC: Implications for a Vascular Endothelial Growth Factor-Dependent Phenotype. J Thorac Oncol, 16: 439-451, 2021
Bayo, J., Fiore, E.J., Dominguez, L.M., Cantero, M.J., Ciarlantini, M.S., Malvicini, M., Atorrasagasti, C., Garcia, M.G., Rossi, M., Cavasotto, C., Martinez, E., Comin, J., Mazzolini, G.D., Bioinformatic analysis of RHO family of GTPases identifies RAC1 pharmacological inhibition as a new therapeutic strategy for hepatocellular carcinoma. Gut, 70: 1362-1374, 2021
Huang, F., Huffman, K.E., Wang, Z., Wang, X., Li, K., Cai, F., Yang, C., Cai, L., Shih, T.S., Zacharias, L.G., Chung, A., Yang, Q., Chalishazar, M.D., Ireland, A.S., Stewart, C.A., Cargill, K., Girard, L., Liu, Y., Ni, M., Xu, J., Wu, X., Zhu, H., Drapkin, B., Byers, L.A., Oliver, T.G., Gazdar, A.F., Minna, J.D., DeBerardinis, R.J., Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer. J Clin Invest, 131, 2021
Bao, J.M., Dang, Q., Lin, C.J., Lo, U.G., Feldkoren, B., Dang, A., Hernandez, E., Li, F., Panwar, V., Lee, C.F., Cen, J.J., Guan, B., Margulis, V., Kapur, P., Brekken, R.A., Luo, J.H., Hsieh, J.T., Tan, W.L., SPARC is a key mediator of TGF-β-induced renal cancer metastasis. J Cell Physiol, 236: 1926-1938, 2021
Drapkin, B.J., Rudin, C.M., Advances in Small-Cell Lung Cancer (SCLC) Translational Research. Cold Spring Harb Perspect Med, 11, 2021
Zhang, Y., Huang, H., Coleman, M., Ziemys, A., Gopal, P., Kazmi, S.M., Brekken, R.A., VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment. JCI Insight, 2021
2020
McCarter, A.L., Khalid, A., Yi, Y., Monroy, M., Zhao, H., Rios, J.J., Dellinger, M.T., Bone development and fracture healing is normal in mice that have a defect in the development of the lymphatic system. Lymphology, 53: 162-171, 2020
Zhang, X., Zhang, R., Chen, H., Wang, L., Ren, C., Pataer, A., Wu, S., Meng, Q.H., Ha, M.J., Morris, J., Xi, Y., Wang, J., Zhang, J., Gibbons, D.L., Heymach, J.V., Meric-Bernstam, F., Minna, J., Swisher, S.G., Roth, J.A., Fang, B., KRT-232 and navitoclax enhance trametinib's anti-Cancer activity in non-small cell lung cancer patient-derived xenografts with KRAS mutations. Am J Cancer Res, 10: 4464-4475, 2020
von Itzstein, M.S., Gonugunta, A.S., Mayo, H.G., Minna, J.D., Gerber, D.E., Immunotherapy Use in Patients With Lung Cancer and Comorbidities. Cancer J, 26: 525-536, 2020
Gong, K., Guo, G., Panchani, N., Bender, M.E., Gerber, D.E., Minna, J.D., Fattah, F., Gao, B., Peyton, M., Kernstine, K., Mukherjee, B., Burma, S., Chiang, C.M., Zhang, S., Amod Sathe, A., Xing, C., Dao, K.H., Zhao, D., Akbay, E.A., Habib, A.A., EGFR inhibition triggers an adaptive response by co-opting antiviral signaling pathways in lung cancer. Nat Cancer, 1: 394-409, 2020
Kim, J., Lee, H.M., Cai, F., Ko, B., Yang, C., Lieu, E.L., Muhammad, N., Rhyne, S., Li, K., Haloul, M., Gu, W., Faubert, B., Kaushik, A.K., Cai, L., Kasiri, S., Marriam, U., Nham, K., Girard, L., Wang, H., Sun, X., Kim, J., Minna, J.D., Unsal-Kacmaz, K., DeBerardinis, R.J., The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer. Nat Metab, 2: 1401-1412, 2020
Layeghi-Ghalehsoukhteh, S., Pal Choudhuri, S., Ocal, O., Zolghadri, Y., Pashkov, V., Niederstrasser, H., Posner, B.A., Kantheti, H.S., Azevedo-Pouly, A.C., Huang, H., Girard, L., MacDonald, R.J., Brekken, R.A., Wilkie, T.M., Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics. Sci Rep, 10: 20662, 2020
Morla, S., Deguchi, H., Fernandez, J.A., Ruf, W., Brekken, R.A., Griffin, J.H., Procoagulant activities of skeletal muscle and cardiac myosins require both myosin protein and myosin-associated anionic phospholipids. Blood, 2020
Zhang, W., Pham, T.H., Wang, D.H., A "Clue" to Improving Liquid Biopsies for Cancer: Microfluidic Multiparametric Exosome Analysis. Clin Chem, 2020
Engelsen, A.S.T., Wnuk-Lipinska, K., Bougnaud, S., Pelissier Vatter, F.A., Tiron, C., Villadsen, R., Miyano, M., Lotsberg, M.L., Madeleine, N., Panahandeh, P., Dhakal, S., Tan, T.Z., Peters, S.D., Grondal, S., Aziz, S.M., Nord, S., Herfindal, L., Stampfer, M.R., Sorlie, T., Brekken, R.A., Straume, O., Halberg, N., Gausdal, G., Thiery, J.P., Akslen, L.A., Petersen, O.W., LaBarge, M.A., Lorens, J.B., AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer. iScience, 23: 101649, 2020
Tlemsani, C., Pongor, L., Elloumi, F., Girard, L., Huffman, K.E., Roper, N., Varma, S., Luna, A., Rajapakse, V.N., Sebastian, R., Kohn, K.W., Krushkal, J., Aladjem, M.I., Teicher, B.A., Meltzer, P.S., Reinhold, W.C., Minna, J.D., Thomas, A., Pommier, Y., SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures. Cell Rep, 33: 108296, 2020
Osborne, J.K., Minna, J.D., Defining the First Part of the Oncogenic KRAS Journey. Cell Stem Cell, 27: 499-500, 2020
von Itzstein, M.S., Burke, M.C., Brekken, R.A., Aguilera, T.A., Zeh, H.J., Beg, M.S., Targeting TAM to Tame Pancreatic Cancer. Target Oncol, 15: 579-588, 2020
Suresh, S., Chen, B., Zhu, J., Golden, R.J., Lu, C., Evers, B.M., Novaresi, N., Smith, B., Zhan, X., Schmid, V., Jun, S., Karacz, C.M., Peyton, M., Zhong, L., Wen, Z., Sathe, A.A., Xing, C., Behrens, C., Wistuba, II, Xiao, G., Xie, Y., Fu, Y.X., Minna, J.D., Mendell, J.T., O'Donnell, K.A., eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer. Nat Cancer, 1: 533-545, 2020
von Itzstein, M.S., Gerber, D.E., Minna, J.D., Do mRNA profiles of lung adenocarcinomas provide information that will help individual patients? EBioMedicine, 60: 103006, 2020
Ganguly, D., Chandra, R., Karalis, J., Teke, M., Aguilera, T., Maddipati, R., Wachsmann, M.B., Ghersi, D., Siravegna, G., Zeh, H.J., 3rd, Brekken, R., Ting, D.T., Ligorio, M., Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment. Cancers (Basel), 12, 2020
Ci, B., Yang, D.M., Cai, L., Yang, L., Girard, L., Fujimoto, J., Wistuba, II, Xie, Y., Minna, J.D., Travis, W., Xiao, G., Molecular differences across invasive lung adenocarcinoma morphological subgroups. Transl Lung Cancer Res, 9: 1029-1040, 2020
Dellinger, M.T., McCormack, F.X., The emergence of targetable MEKanisms in sporadic lymphatic disorders. EMBO Mol Med, 12: e12822, 2020
Wang, Y., Ma, J., Martinez, E.D., Liang, D., Xie, H., A UHPLC-MS/MS method for the quantification of JIB-04 in rat plasma: Development, validation and application to pharmacokinetics study. J Pharm Biomed Anal, 191: 113587, 2020
Gerber, D.E., Putnam, W.C., Fattah, F.J., Kernstine, K.H., Brekken, R.A., Pedrosa, I., Skelton, R., Saltarski, J.M., Lenkinski, R.E., Leff, R.D., Ahn, C., Padmanabhan, C., Chembukar, V., Kasiri, S., Kallem, R.R., Subramaniyan, I., Yuan, Q., Do, Q.N., Xi, Y., Reznik, S.I., Pelosof, L., Faubert, B., DeBerardinis, R.J., Kim, J., Concentration-dependent Early Antivascular and Antitumor Effects of Itraconazole in Non-Small Cell Lung Cancer. Clin Cancer Res, 26: 6017-6027, 2020
Chung, A.S., Mettlen, M., Ganguly, D., Lu, T., Wang, T., Brekken, R.A., Hsiehchen, D., Zhu, H., Immune Checkpoint Inhibition is Safe and Effective for Liver Cancer Prevention in a Mouse Model of Hepatocellular Carcinoma. Cancer Prev Res (Phila), 13: 911-922, 2020
Scarpignato, C., Sloan, J.A., Wang, D.H., Hunt, R.H., Gastrointestinal pharmacology: practical tips for the esophagologist. Ann N Y Acad Sci, 1481: 90-107, 2020
Drapkin, B.J., Minna, J.D., Studying Lineage Plasticity One Cell at a Time. Cancer Cell, 38: 150-152, 2020
Badgery, H., Chong, L., Iich, E., Huang, Q., Georgy, S.R., Wang, D.H., Read, M., Recent insights into the biology of Barrett's esophagus. Ann N Y Acad Sci, 1481: 198-209, 2020
Westcott, J.M., Camacho, S., Nasir, A., Huysman, M.E., Rahhal, R., Dang, T.T., Riegel, A.T., Brekken, R.A., Pearson, G.W., DeltaNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader-Follower Relationship That Drives Collective Invasion. Cancer Res, 80: 3933-3944, 2020
Sato, M., Shay, J.W., Minna, J.D., Immortalized normal human lung epithelial cell models for studying lung cancer biology. Respir Investig, 58: 344-354, 2020
Drapkin, B.J., Rudin, C.M., Advances in Small-Cell Lung Cancer (SCLC) Translational Research. Cold Spring Harb Perspect Med, 2020
Hight, S.K., Mootz, A., Kollipara, R.K., McMillan, E., Yenerall, P., Otaki, Y., Li, L.S., Avila, K., Peyton, M., Rodriguez-Canales, J., Mino, B., Villalobos, P., Girard, L., Dospoy, P., Larsen, J., White, M.A., Heymach, J.V., Wistuba, II, Kittler, R., Minna, J.D., An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis. Neoplasia, 22: 294-310, 2020
Huang, H., Brekken, R.A., Beyond Stiffness: Collagen Signaling in Pancreatic Cancer and Pancreas Regeneration. Am J Pathol, 190: 1622-1624, 2020
Shukla, A., Ramirez, N.P., D'Orso, I., HIV-1 Proviral Transcription and Latency in the New Era. Viruses, 12, 2020
Huang, H., Brekken, R.A., Recent advances in understanding cancer-associated fibroblasts in pancreatic cancer. Am J Physiol Cell Physiol, 319: C233-C243, 2020
Luo, S.Y., Kwok, H.H., Yang, P.C., Ip, M.S., Minna, J.D., Lam, D.C., Expression of large tumour suppressor (LATS) kinases modulates chemotherapy response in advanced non-small cell lung cancer. Transl Lung Cancer Res, 9: 294-305, 2020
Hosein, A.N., Brekken, R.A., Maitra, A., Pancreatic cancer stroma: an update on therapeutic targeting strategies. Nat Rev Gastroenterol Hepatol, 17: 487-505, 2020
Brekken, R.A., Loss of BAP1 Leads to More YAPing in Pancreatic Cancer. Cancer Res, 80: 1624-1625, 2020
Matthews, K.A., Senagbe, K.M., Notzel, C., Gonzales, C.A., Tong, X., Rijo-Ferreira, F., Bhanu, N.V., Miguel-Blanco, C., Lafuente-Monasterio, M.J., Garcia, B.A., Kafsack, B.F.C., Martinez, E.D., Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases. ACS Infect Dis, 6: 1058-1075, 2020
Bae, C.A., Ham, I.H., Oh, H.J., Lee, D., Woo, J., Son, S.Y., Yoon, J.H., Lorens, J.B., Brekken, R.A., Kim, T.M., Han, S.U., Park, W.S., Hur, H., Inhibiting the GAS6/AXL axis suppresses tumor progression by blocking the interaction between cancer-associated fibroblasts and cancer cells in gastric carcinoma. Gastric Cancer, 23: 824-836, 2020
Lee, M.H., Yanagawa, J., Tran, L., Walser, T.C., Bisht, B., Fung, E., Park, S.J., Zeng, G., Krysan, K., Wallace, W.D., Paul, M.K., Girard, L., Gao, B., Minna, J.D., Dubinett, S.M., Lee, J.M., FRA1 contributes to MEK-ERK pathway-dependent PD-L1 upregulation by KRAS mutation in premalignant human bronchial epithelial cells. Am J Transl Res, 12: 409-427, 2020
Monroy, M., McCarter, A.L., Hominick, D., Cassidy, N., Dellinger, M.T., Lymphatics in bone arise from pre-existing lymphatics. Development, 147, 2020
Kasiri, S., Chen, B., Wilson, A.N., Reczek, A., Mazambani, S., Gadhvi, J., Noel, E., Marriam, U., Mino, B., Lu, W., Girard, L., Solis, L.M., Luby-Phelps, K., Bishop, J., Kim, J.W., Kim, J., Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species. Oncogene, 39: 3258-3275, 2020
Dayoub, A.S., Brekken, R.A., TIMs, TAMs, and PS- antibody targeting: implications for cancer immunotherapy. Cell Commun Signal, 18: 29, 2020
Park, J.S., Burckhardt, C.J., Lazcano, R., Solis, L.M., Isogai, T., Li, L., Chen, C.S., Gao, B., Minna, J.D., Bachoo, R., DeBerardinis, R.J., Danuser, G., Mechanical regulation of glycolysis via cytoskeleton architecture. Nature, 578: 621-626, 2020
Poirier, J.T., George, J., Owonikoko, T.K., Berns, A., Brambilla, E., Byers, L.A., Carbone, D., Chen, H.J., Christensen, C.L., Dive, C., Farago, A.F., Govindan, R., Hann, C., Hellmann, M.D., Horn, L., Johnson, J.E., Ju, Y.S., Kang, S., Krasnow, M., Lee, J., Lee, S.H., Lehman, J., Lok, B., Lovly, C., MacPherson, D., McFadden, D., Minna, J., Oser, M., Park, K., Park, K.S., Pommier, Y., Quaranta, V., Ready, N., Sage, J., Scagliotti, G., Sos, M.L., Sutherland, K.D., Travis, W.D., Vakoc, C.R., Wait, S.J., Wistuba, I., Wong, K.K., Zhang, H., Daigneault, J., Wiens, J., Rudin, C.M., Oliver, T.G., New Approaches to SCLC Therapy: From the Laboratory to the Clinic. J Thorac Oncol, 15: 520-540, 2020
Lotsberg, M.L., Wnuk-Lipinska, K., Terry, S., Tan, T.Z., Lu, N., Trachsel-Moncho, L., Rosland, G.V., Siraji, M.I., Hellesoy, M., Rayford, A., Jacobsen, K., Ditzel, H.J., Vintermyr, O.K., Bivona, T.G., Minna, J., Brekken, R.A., Baguley, B., Micklem, D., Akslen, L.A., Gausdal, G., Simonsen, A., Thiery, J.P., Chouaib, S., Lorens, J.B., Engelsen, A.S.T., AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells. J Thorac Oncol, 15: 973-999, 2020
Mender, I., Batten, K., Peyton, M., Vemula, A., Cornelius, C., Girard, L., Gao, B., Minna, J.D., Shay, J.W., SLC43A3 Is a Biomarker of Sensitivity to the Telomeric DNA Damage Mediator 6-Thio-2'-Deoxyguanosine. Cancer Res, 80: 929-936, 2020
Wang, S., Rong, R., Yang, D.M., Fujimoto, J., Yan, S., Cai, L., Yang, L., Luo, D., Behrens, C., Parra, E.R., Yao, B., Xu, L., Wang, T., Zhan, X., Wistuba, II, Minna, J., Xie, Y., Xiao, G., Computational Staining of Pathology Images to Study the Tumor Microenvironment in Lung Cancer. Cancer Res, 80: 2056-2066, 2020
Yenerall, P., Das, A.K., Wang, S., Kollipara, R.K., Li, L.S., Villalobos, P., Flaming, J., Lin, Y.F., Huffman, K., Timmons, B.C., Gilbreath, C., Sonavane, R., Kinch, L.N., Rodriguez-Canales, J., Moran, C., Behrens, C., Hirasawa, M., Takata, T., Murakami, R., Iwanaga, K., Chen, B.P.C., Grishin, N.V., Raj, G.V., Wistuba, II, Minna, J.D., Kittler, R., RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer. Cell Chem Biol, 27: 105-121.e14, 2020
Zi, Z., Zhang, Y., Zhang, P., Ding, Q., Chu, M., Chen, Y., Minna, J.D., Yu, Y., A Proteomic Connectivity Map for Characterizing the Tumor Adaptive Response to Small Molecule Chemical Perturbagens. ACS Chem Biol, 15: 140-150, 2020
Shimada, Y., Kudo, Y., Maehara, S., Matsubayashi, J., Otaki, Y., Kajiwara, N., Ohira, T., Minna, J.D., Ikeda, N., Ubiquitin C-terminal hydrolase-L1 has prognostic relevance and is a therapeutic target for high-grade neuroendocrine lung cancers. Cancer Sci, 111: 610-620, 2020
Zhang, W., Williams, T.A., Bhagwath, A.S., Hiermann, J.S., Peacock, C.D., Watkins, D.N., Ding, P., Park, J.Y., Montgomery, E.A., Forastiere, A.A., Jie, C., Cantarel, B.L., Pham, T.H., Wang, D.H., GEAMP, a novel gastroesophageal junction carcinoma cell line derived from a malignant pleural effusion. Lab Invest, 100: 16-26, 2020
Yanev, P., Poinsatte, K., Hominick, D., Khurana, N., Zuurbier, K.R., Berndt, M., Plautz, E.J., Dellinger, M.T., Stowe, A.M., Impaired meningeal lymphatic vessel development worsens stroke outcome. J Cereb Blood Flow Metab, 40: 263-275, 2020
2019
Mulshine, J.L., Ujhazy, P., Antman, M., Burgess, C.M., Kuzmin, I., Bunn, P.A., Jr., Johnson, B.E., Roth, J.A., Pass, H.I., Ross, S.M., Aldige, C.R., Wistuba, II, Minna, J.D., From clinical specimens to human cancer preclinical models-a journey the NCI-cell line database-25 years later. J Cell Biochem, 121: 3986-99, 2019
Cuevas, I.C., Sahoo, S.S., Kumar, A., Zhang, H., Westcott, J., Aguilar, M., Cortez, J.D., Sullivan, S.A., Xing, C., Hayes, D.N., Brekken, R.A., Bae-Jump, V.L., Castrillon, D.H., Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition. Proc Natl Acad Sci U S A, 116: 25880-25890, 2019
Wang, W., Wang, H., Zhou, X., Li, X., Sun, W., Dellinger, M., Boyce, B.F., Xing, L., Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice. J Bone Miner Res, 34: 2162, 2019
Arner, E.N., Du, W., Brekken, R.A., Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers. Front Oncol, 9: 1049, 2019
Huang, H., Zhang, Y., Gallegos, V., Sorrelle, N., Zaid, M.M., Toombs, J., Du, W., Wright, S., Hagopian, M., Wang, Z., Hosein, A.N., Sathe, A.A., Xing, C., Koay, E.J., Driscoll, K.E., Brekken, R.A., Targeting TGFbetaR2-mutant tumors exposes vulnerabilities to stromal TGFbeta blockade in pancreatic cancer. EMBO Mol Med, 11: e10515, 2019
Liang, Y., Besch-Williford, C., Cook, M.T., Belenchia, A., Brekken, R.A., Hyder, S.M., APR-246 alone and in combination with a phosphatidylserine-targeting antibody inhibits lung metastasis of human triple-negative breast cancer cells in nude mice. Breast Cancer (Dove Med Press), 11: 249-259, 2019
Zoeller, E.L., Pedro, B., Konen, J., Dwivedi, B., Rupji, M., Sundararaman, N., Wang, L., Horton, J.R., Zhong, C., Barwick, B.G., Cheng, X., Martinez, E.D., Torres, M.P., Kowalski, J., Marcus, A.I., Vertino, P.M., Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes. J Cell Sci, 132, 2019
Tuladhar, R., Yeu, Y., Tyler Piazza, J., Tan, Z., Rene Clemenceau, J., Wu, X., Barrett, Q., Herbert, J., Mathews, D.H., Kim, J., Hyun Hwang, T., Lum, L., CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation. Nat Commun, 10: 4056, 2019
Hsieh, M.H., Choe, J.H., Gadhvi, J., Kim, Y.J., Arguez, M.A., Palmer, M., Gerold, H., Nowak, C., Do, H., Mazambani, S., Knighton, J.K., Cha, M., Goodwin, J., Kang, M.K., Jeong, J.Y., Lee, S.Y., Faubert, B., Xuan, Z., Abel, E.D., Scafoglio, C., Shackelford, D.B., Minna, J.D., Singh, P.K., Shulaev, V., Bleris, L., Hoyt, K., Kim, J., Inoue, M., DeBerardinis, R.J., Kim, T.H., Kim, J.W., p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Cell Rep, 28: 1860-1878.e9, 2019
Hosein, A.N., Huang, H., Wang, Z., Parmar, K., Du, W., Huang, J., Maitra, A., Olson, E., Verma, U., Brekken, R.A., Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution. JCI Insight, 5, 2019
Zhu, D., Huang, H., Pinkas, D.M., Luo, J., Ganguly, D., Fox, A.E., Arner, E., Xiang, Q., Tu, Z.C., Bullock, A.N., Brekken, R.A., Ding, K., Lu, X., 2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy. J Med Chem, 62: 7431-7444, 2019
Faubert, B., DeBerardinis, R.J., Minna, J.D., AIF: an acquired metabolic liability in lung cancer. Cell Res, 29: 607-608, 2019
Stefanius, K., Servage, K., de Souza Santos, M., Gray, H.F., Toombs, J.E., Chimalapati, S., Kim, M.S., Malladi, V.S., Brekken, R., Orth, K., Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation. Elife, 8, 2019
Huang, H., Wright, S., Zhang, J., Brekken, R.A., Getting a grip on adhesion: Cadherin switching and collagen signaling. Biochim Biophys Acta Mol Cell Res, 1866: 118472, 2019
Cruz, V.H., Arner, E.N., Du, W., Bremauntz, A.E., Brekken, R.A., Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer. JCI Insight, 5, 2019
Ham, I.H., Oh, H.J., Jin, H., Bae, C.A., Jeon, S.M., Choi, K.S., Son, S.Y., Han, S.U., Brekken, R.A., Lee, D., Hur, H., Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer. Mol Cancer, 18: 68, 2019
Rudin, C.M., Poirier, J.T., Byers, L.A., Dive, C., Dowlati, A., George, J., Heymach, J.V., Johnson, J.E., Lehman, J.M., MacPherson, D., Massion, P.P., Minna, J.D., Oliver, T.G., Quaranta, V., Sage, J., Thomas, R.K., Vakoc, C.R., Gazdar, A.F., Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Nat Rev Cancer, 19: 289-297, 2019
Haave, T.R., Manstad-Hulaas, F., Brekken, R., Treatment of restenosis in radiocephalic arteriovenous hemodialysis fistulas: percutaneous transluminal angioplasty or drug-coated balloon. Acta Radiol, 60: 1584-1589, 2019
Bayo, J., Fiore, E.J., Dominguez, L.M., Real, A., Malvicini, M., Rizzo, M., Atorrasagasti, C., Garcia, M.G., Argemi, J., Martinez, E.D., Mazzolini, G.D., A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets. J Hepatol, 71: 78-90, 2019
Le, T., Minna, J.D., Gerber, D.E., Checkpoint Inhibitor Pneumonitis: Too Clinically Serious For Benefit? J Thorac Oncol, 14: 332-335, 2019
Gazdar, A.F., Minna, J.D., Small cell lung cancers made from scratch. J Exp Med, 216: 476-478, 2019
Tuladhar, R., Yarravarapu, N., Ma, Y., Zhang, C., Herbert, J., Kim, J., Chen, C., Lum, L., Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN). J Biol Chem, 294: 6273-6282, 2019
Zhou, H., Belzile, O., Zhang, Z., Wagner, J., Ahn, C., Richardson, J.A., Saha, D., Brekken, R.A., Mason, R.P., The effect of flow on blood oxygen level dependent (R(*) 2 ) MRI of orthotopic lung tumors. Magn Reson Med, 81: 3787-3797, 2019
Ye, R., Onodera, T., Blanchard, P.G., Kusminski, C.M., Esser, V., Brekken, R.A., Scherer, P.E., beta1 Syntrophin Supports Autophagy Initiation and Protects against Cerulein-Induced Acute Pancreatitis. Am J Pathol, 189: 813-825, 2019
Huang, H., Brekken, R.A., The Next Wave of Stroma-Targeting Therapy in Pancreatic Cancer. Cancer Res, 79: 328-330, 2019
Rodriguez-Laguna, L., Agra, N., Ibanez, K., Oliva-Molina, G., Gordo, G., Khurana, N., Hominick, D., Beato, M., Colmenero, I., Herranz, G., Torres Canizalez, J.M., Rodriguez Pena, R., Vallespin, E., Martin-Arenas, R., Del Pozo, A., Villaverde, C., Bustamante, A., Ayuso, C., Lapunzina, P., Lopez-Gutierrez, J.C., Dellinger, M.T., Martinez-Glez, V., Somatic activating mutations in PIK3CA cause generalized lymphatic anomaly. J Exp Med, 216: 407-418, 2019
Zhang, L.S., Kang, X., Lu, J., Zhang, Y., Wu, X., Wu, G., Zheng, J., Tuladhar, R., Shi, H., Wang, Q., Morlock, L., Yao, H., Huang, L.J., Maire, P., Kim, J., Williams, N., Xu, J., Chen, C., Zhang, C.C., Lum, L., Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9. EBioMedicine, 39: 145-158, 2019
Sorrelle, N., Ganguly, D., Dominguez, A.T.A., Zhang, Y., Huang, H., Dahal, L.N., Burton, N., Ziemys, A., Brekken, R.A., Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues. J Immunol, 202: 292-299, 2019
Huang, H., Salavaggione, O., Rivera, L., Mukherjee, S., Brekken, R., Tennant, B., Iyer, R., Adjei, A., Woodchuck VEGF (wVEGF) characteristics: Model for angiogenesis and human hepatocellular carcinoma directed therapies. Arch Biochem Biophys, 661: 97-106, 2019
Yan, X., Zhang, X., Wang, L., Zhang, R., Pu, X., Wu, S., Li, L., Tong, P., Wang, J., Meng, Q.H., Jensen, V.B., Girard, L., Minna, J.D., Roth, J.A., Swisher, S.G., Heymach, J.V., Fang, B., Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis. Cancer Res, 79: 125-132, 2019
Zhang, Y., Kirane, A., Huang, H., Sorrelle, N.B., Burrows, F.J., Dellinger, M.T., Brekken, R.A., Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer. Mol Cancer Res, 17: 348-355, 2019
Xie, Y., Lu, W., Wang, S., Tang, X., Tang, H., Zhou, Y., Moran, C., Behrens, C., Roth, J.A., Zhou, Q., Johnson, D.H., Swisher, S.G., Heymach, J.V., Papadimitrakopoulou, V.A., Xiao, G., Minna, J.D., Wistuba, II, Validation of the 12-gene Predictive Signature for Adjuvant Chemotherapy Response in Lung Cancer. Clin Cancer Res, 25: 150-157, 2019
Li, X., Lee, Y., Kang, Y., Dai, B., Perez, M.R., Pratt, M., Koay, E.J., Kim, M., Brekken, R.A., Fleming, J.B., Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma. Cell Death Differ, 26: 382-393, 2019
2018
Cai, L., Lin, S., Girard, L., Zhou, Y., Yang, L., Ci, B., Zhou, Q., Luo, D., Yao, B., Tang, H., Allen, J., Huffman, K., Gazdar, A., Heymach, J., Wistuba, I., Xiao, G., Minna, J., Xie, Y., LCE: an open web portal to explore gene expression and clinical associations in lung cancer. Oncogene, 2018
Zhang, Q.J., Tran, T.A.T., Wang, M., Ranek, M.J., Kokkonen-Simon, K.M., Gao, J., Luo, X., Tan, W., Kyrychenko, V., Liao, L., Xu, J., Hill, J.A., Olson, E.N., Kass, D.A., Martinez, E.D., Liu, Z.P., Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis. Nat Commun, 9: 5230, 2018
Updegraff, B.L., Zhou, X., Guo, Y., Padanad, M.S., Chen, P.H., Yang, C., Sudderth, J., Rodriguez-Tirado, C., Girard, L., Minna, J.D., Mishra, P., DeBerardinis, R.J., O'Donnell, K.A., Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism. Cell Rep, 25: 2223-2233 e6, 2018
Du, W., Huang, H., Sorrelle, N., Brekken, R.A., Sitravatinib potentiates immune checkpoint blockade in refractory cancer models. JCI Insight, 3, 2018
Bayo, J., Tran, T.A., Wang, L., Pena-Llopis, S., Das, A.K., Martinez, E.D., Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks. Cell Rep, 25: 1040-1050 e5, 2018
Ruder, D., Papadimitrakopoulou, V., Shien, K., Behrens, C., Kalhor, N., Chen, H., Shen, L., Lee, J.J., Hong, W.K., Tang, X., Girard, L., Minna, J.D., Diao, L., Wang, J., Mino, B., Villalobos, P., Rodriguez-Canales, J., Hanson, N.E., Sun, J., Miller, V., Greenbowe, J., Frampton, G., Herbst, R.S., Baladandayuthapani, V., Wistuba, II, Izzo, J.G., Concomitant targeting of the mTOR/MAPK pathways: novel therapeutic strategy in subsets of RICTOR/KRAS-altered non-small cell lung cancer. Oncotarget, 9: 33995-34008, 2018
Pozo, K., Kelenis, D.P., Minna, J.D., Johnson, J.E., Different Originating Cells Underlie Intertumoral Heterogeneity in Lung Neuroendocrine Tumors. Cancer Discov, 8: 1216-1218, 2018
Du, W., Brekken, R.A., Does Axl have potential as a therapeutic target in pancreatic cancer? Expert Opin Ther Targets, 22: 955-966, 2018
Akbay, E.A., Kim, J., Autochthonous murine models for the study of smoker and never-smoker associated lung cancers. Transl Lung Cancer Res, 7: 464-486, 2018
Song, K., Bi, J.H., Qiu, Z.W., Felizardo, R., Girard, L., Minna, J.D., Gazdar, A.F., A quantitative method for assessing smoke associated molecular damage in lung cancers. Transl Lung Cancer Res, 7: 439-449, 2018
Gazdar, A.F., Preface: lung cancer in never smokers. Transl Lung Cancer Res, 7: 437-438, 2018
Hiramitsu, S., Ishikawa, T., Lee, W.R., Khan, T., Crumbley, C., Khwaja, N., Zamanian, F., Asghari, A., Sen, M., Zhang, Y., Hawse, J.R., Minna, J.D., Umetani, M., Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol. Front Endocrinol (Lausanne), 9: 470, 2018
Nichols, B.A., Oswald, N.W., McMillan, E.A., McGlynn, K., Yan, J., Kim, M.S., Saha, J., Mallipeddi, P.L., LaDuke, S.A., Villalobos, P.A., Rodriguez-Canales, J., Wistuba, II, Posner, B.A., Davis, A.J., Minna, J.D., MacMillan, J.B., Whitehurst, A.W., HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress. Cancer Res, 78: 6196-6208, 2018
Jia, D., Augert, A., Kim, D.W., Eastwood, E., Wu, N., Ibrahim, A.H., Kim, K.B., Dunn, C.T., Pillai, S.P.S., Gazdar, A.F., Bolouri, H., Park, K.S., MacPherson, D., Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition. Cancer Discov, 8: 1422-1437, 2018
Motea, E.A., Fattah, F.J., Xiao, L., Girard, L., Rommel, A., Morales, J.C., Patidar, P., Zhou, Y., Porter, A., Xie, Y., Minna, J.D., Boothman, D.A., Kub5-Hera (RPRD1B) Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers. Clin Cancer Res, 24: 6459-6470, 2018
Raman, P., Maddipati, R., Lim, K.H., Tozeren, A., Pancreatic cancer survival analysis defines a signature that predicts outcome. PLoS One, 13: e0201751, 2018
Wang, Z., Zhang, Y., Pinkas, D.M., Fox, A.E., Luo, J., Huang, H., Cui, S., Xiang, Q., Xu, T., Xun, Q., Zhu, D., Tu, Z., Ren, X., Brekken, R.A., Bullock, A.N., Liang, G., Ding, K., Lu, X., Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2. J Med Chem, 61: 7977-7990, 2018
Huang, F., Ni, M., Chalishazar, M.D., Huffman, K.E., Kim, J., Cai, L., Shi, X., Cai, F., Zacharias, L.G., Ireland, A.S., Li, K., Gu, W., Kaushik, A.K., Liu, X., Gazdar, A.F., Oliver, T.G., Minna, J.D., Hu, Z., DeBerardinis, R.J., Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers. Cell Metab, 28: 369-382 e5, 2018
Du, L., Zhao, Z., Suraokar, M., Shelton, S.S., Ma, X., Hsiao, T.H., Minna, J.D., Wistuba, I., Pertsemlidis, A., LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer. Oncotarget, 9: 29601-29618, 2018
Mender, I., LaRanger, R., Luitel, K., Peyton, M., Girard, L., Lai, T.P., Batten, K., Cornelius, C., Dalvi, M.P., Ramirez, M., Du, W., Wu, L.F., Altschuler, S.J., Brekken, R., Martinez, E.D., Minna, J.D., Wright, W.E., Shay, J.W., Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance. Neoplasia, 20: 826-837, 2018
Sathyanarayana, U.G., Moore, A.Y., Li, L., Padar, A., Majmudar, K., Stastny, V., Makarla, P., Suzuki, M., Minna, J.D., Feng, Z., Gazdar, A.F., Retraction notice to "Sun exposure related methylation in malignant and non-malignant skin lesions" [Cancer Letters 245/1-2 (2007) 112-120]. Cancer Lett, 432: 272, 2018
Wang, S., Chen, A., Yang, L., Cai, L., Xie, Y., Fujimoto, J., Gazdar, A., Xiao, G., Comprehensive analysis of lung cancer pathology images to discover tumor shape and boundary features that predict survival outcome. Sci Rep, 8: 10393, 2018
Pozo, K., Minna, J.D., Johnson, J.E., Identifying a missing lineage driver in a subset of lung neuroendocrine tumors. Genes Dev, 32: 865-867, 2018
Cruz, V.H., Arner, E.N., Wynne, K.W., Scherer, P.E., Brekken, R.A., Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction. Mol Metab, 16: 139-149, 2018
Reichert, M., Bakir, B., Moreira, L., Pitarresi, J.R., Feldmann, K., Simon, L., Suzuki, K., Maddipati, R., Rhim, A.D., Schlitter, A.M., Kriegsmann, M., Weichert, W., Wirth, M., Schuck, K., Schneider, G., Saur, D., Reynolds, A.B., Klein-Szanto, A.J., Pehlivanoglu, B., Memis, B., Adsay, N.V., Rustgi, A.K., Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer. Dev Cell, 45: 696-711.e8, 2018
Aiello, N.M., Maddipati, R., Norgard, R.J., Balli, D., Li, J., Yuan, S., Yamazoe, T., Black, T., Sahmoud, A., Furth, E.E., Bar-Sagi, D., Stanger, B.Z., EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration. Dev Cell, 45: 681-695.e4, 2018
Jin, H., Ham, I.H., Oh, H.J., Bae, C.A., Lee, D., Kim, Y.B., Son, S.Y., Chwae, Y.J., Han, S.U., Brekken, R.A., Hur, H., Inhibition of Discoidin Domain Receptor 1 Prevents Stroma-Induced Peritoneal Metastasis in Gastric Carcinoma. Mol Cancer Res, 16: 1590-1600, 2018
Rashdan, S., Minna, J.D., Gerber, D.E., Diagnosis and management of pulmonary toxicity associated with cancer immunotherapy. Lancet Respir Med, 6: 472-478, 2018
Dellinger, M.T., Witte, M.H., Lymphangiogenesis, lymphatic systemomics, and cancer: context, advances and unanswered questions. Clin Exp Metastasis, 35: 419-424, 2018
Li, Q., Wang, X., Liang, F., Yi, F., Xie, Y., Gazdar, A., Xiao, G., A Bayesian hidden Potts mixture model for analyzing lung cancer pathology images. Biostatistics, 2018
Yang, L., Wang, S., Gerber, D.E., Zhou, Y., Xu, F., Liu, J., Liang, H., Xiao, G., Zhou, Q., Gazdar, A., Xie, Y., Main bronchus location is a predictor for metastasis and prognosis in lung adenocarcinoma: A large cohort analysis. Lung Cancer, 120: 22-26, 2018
McMillan, E.A., Ryu, M.J., Diep, C.H., Mendiratta, S., Clemenceau, J.R., Vaden, R.M., Kim, J.H., Motoyaji, T., Covington, K.R., Peyton, M., Huffman, K., Wu, X., Girard, L., Sung, Y., Chen, P.H., Mallipeddi, P.L., Lee, J.Y., Hanson, J., Voruganti, S., Yu, Y., Park, S., Sudderth, J., DeSevo, C., Muzny, D.M., Doddapaneni, H., Gazdar, A., Gibbs, R.A., Hwang, T.H., Heymach, J.V., Wistuba, I., Coombes, K.R., Williams, N.S., Wheeler, D.A., MacMillan, J.B., Deberardinis, R.J., Roth, M.G., Posner, B.A., Minna, J.D., Kim, H.S., White, M.A., Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell, 173: 864-878 e29, 2018
Fu, G., Sanjay, S.T., Zhou, W., Brekken, R.A., Kirken, R.A., Li, X., Exploration of Nanoparticle-Mediated Photothermal Effect of TMB-H2O2 Colorimetric System and Its Application in a Visual Quantitative Photothermal Immunoassay. Anal Chem, 90: 5930-5937, 2018
Kim, J., Minna, J.D., Evaluating tumor-suppressor gene combinations. Nat Genet, 50: 480-482, 2018
Tanaka, I., Sato, M., Kato, T., Goto, D., Kakumu, T., Miyazawa, A., Yogo, N., Hase, T., Morise, M., Sekido, Y., Girard, L., Minna, J.D., Byers, L.A., Heymach, J.V., Coombes, K.R., Kondo, M., Hasegawa, Y., eIF2beta, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer. Cancer Sci, 109: 1843-1852, 2018
Hominick, D., Silva, A., Khurana, N., Liu, Y., Dechow, P.C., Feng, J.Q., Pytowski, B., Rutkowski, J.M., Alitalo, K., Dellinger, M.T., VEGF-C promotes the development of lymphatics in bone and bone loss. Elife, 7, 2018
Gong, K., Guo, G., Gerber, D.E., Gao, B., Peyton, M., Huang, C., Minna, J.D., Hatanpaa, K.J., Kernstine, K., Cai, L., Xie, Y., Zhu, H., Fattah, F.J., Zhang, S., Takahashi, M., Mukherjee, B., Burma, S., Dowell, J., Dao, K., Papadimitrakopoulou, V.A., Olivas, V., Bivona, T.G., Zhao, D., Habib, A.A., TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer. J Clin Invest, 128: 2500-2518, 2018
Manders, D.B., Kishore, H.A., Gazdar, A.F., Keller, P.W., Tsunezumi, J., Yanagisawa, H., Lea, J., Word, R.A., Dysregulation of fibulin-5 and matrix metalloproteases in epithelial ovarian cancer. Oncotarget, 9: 14251-14267, 2018
Kontarakis, Z., Rossi, A., Ramas, S., Dellinger, M.T., Stainier, D.Y.R., Mir-126 is a conserved modulator of lymphatic development. Dev Biol, 437: 120-130, 2018
Zhang, W., Girard, L., Zhang, Y.A., Haruki, T., Papari-Zareei, M., Stastny, V., Ghayee, H.K., Pacak, K., Oliver, T.G., Minna, J.D., Gazdar, A.F., Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes. Transl Lung Cancer Res, 7: 32-49, 2018
Yingling, J.M., McMillen, W.T., Yan, L., Huang, H., Sawyer, J.S., Graff, J., Clawson, D.K., Britt, K.S., Anderson, B.D., Beight, D.W., Desaiah, D., Lahn, M.M., Benhadji, K.A., Lallena, M.J., Holmgaard, R.B., Xu, X., Zhang, F., Manro, J.R., Iversen, P.W., Iyer, C.V., Brekken, R.A., Kalos, M.D., Driscoll, K.E., Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-beta receptor type I inhibitor. Oncotarget, 9: 6659-6677, 2018
Walser, T.C., Jing, Z., Tran, L.M., Lin, Y.Q., Yakobian, N., Wang, G., Krysan, K., Zhu, L.X., Sharma, S., Lee, M.H., Belperio, J.A., Ooi, A.T., Gomperts, B.N., Shay, J.W., Larsen, J.E., Minna, J.D., Hong, L.S., Fishbein, M.C., Dubinett, S.M., Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells. Cancer Res, 78: 1986-1999, 2018
Gazdar, A.F., Morphologic and Other Forms of Heterogeneity in Small Cell Lung Cancer: What Can We Learn from Them? J Thorac Oncol, 13: 148-150, 2018
Belzile, O., Huang, X., Gong, J., Carlson, J., Schroit, A.J., Brekken, R.A., Freimark, B.D., Antibody targeting of phosphatidylserine for the detection and immunotherapy of cancer. Immunotargets Ther, 7: 1-14, 2018
He, M., Liu, S., Gallolu Kankanamalage, S., Borromeo, M.D., Girard, L., Gazdar, A.F., Minna, J.D., Johnson, J.E., Cobb, M.H., The Epithelial Sodium Channel (alphaENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors. Transl Oncol, 11: 292-299, 2018
Fan, C.W., Yarravarapu, N., Shi, H., Kulak, O., Kim, J., Chen, C., Lum, L., A synthetic combinatorial approach to disabling deviant Hedgehog signaling. Sci Rep, 8: 1133, 2018
Cruz, V.H., Brekken, R.A., Assessment of TANK-binding kinase 1 as a therapeutic target in cancer. J Cell Commun Signal, 12: 83-90, 2018
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