Department of Biochemistry
About Our Department
The Department of Biochemistry at UT Southwestern is a hub for innovation at the interface of chemistry and biology, fueling transformative advances in medicine, biotechnology, and beyond. Our scientists explore fundamental questions through the mechanistic study of metabolic pathways, catalytic enzymes, and their regulatory processes. Much of our work focuses on developing a better understanding of diseases, and projects within the department have advanced drug discovery in areas such as cancer, immune diseases, metabolic disorders, and malaria. Our collaborative, interdisciplinary environment fosters discovery at the interface of chemistry, biology, and medicine, while training the next generation of scientists to think creatively and push boundaries.
The department is actively recruiting new faculty in research areas that complement our mission.
Department News
Get news from UT Southwestern Biochemists or news@utsouthwestern.edu our media relations team.
Recent Publications
- Bench-stable reagents for modular access to persulfuranyl scaffolds. Li, R., Liu, C., Hu, C. et al. Nature Communications (2025).
- Total Synthesis of Annotinolide B via Sequential Quinoline Dearomatization. Duvvuru, B., Smith, M. W. Journal of the American Chemical Society (2025).
- Fucosylation of glycoproteins and glycolipids: opposing roles in cholera intoxication. Ghorashi, A. C., Boucher, A., Archer-Hartmann, S. A. et al. Nature Chemical Biology (2025).
- Structural basis for substrate selectivity by site-one protease revealed by studies with a small-molecule inhibitor. Bullington, A. V., Micallo, I., Bajaj, B. et al. Proceedings of the National Academy of Sciences (2025).
- The yeast Mkt1/Pbp1 complex promotes adaptive responses to respiratory growth. Caballero, D., Sutter, B. M., Xing, Z. et al. Journal of Cell Biology (2025).
