Publications
2023
Cross-Linking Mass Spectrometry Analysis of Metastable Compact Structures in Intrinsically Disordered Proteins
Chen D, Joachimiak LA, Methods Mol Biol 2023 2551 189-201
2022
The interactions that shape amyloid fibrils in disease
Joachimiak LA, Structure 2022 Aug 30 8 1045-1047
Update on Disease-Specific Biomarkers in Transthyretin Cardiac Amyloidosis
Hood CJ, Hendren NS, Pedretti R, Roth LR, Saelices L, Grodin JL, Curr Heart Fail Rep 2022 Aug
Structural polymorphism of amyloid fibrils in cardiac ATTR amyloidosis revealed by cryo-electron microscopy
Nguyen BA, Afrin S, Singh V, Ahmed Y, Pedretti R, Fernandez-Ramirez M, Benson MD, Sawaya RM, Cao Q, Boyer D, Pope A, Wydorski PM, Chhapra F, Eisenberg DS, Saelices L bioRxiv 2022 496949 2022.06.21
Seed-competent tau monomer initiates pathology in a tauopathy mouse model
Mirbaha H, Chen D, Mullapudi V, Terpack SJ, White CL, Joachimiak LA, Diamond MI, J Biol Chem 2022 Jun 102163
RNA induces unique tau strains and stabilizes Alzheimer's disease seeds
Zwierzchowski-Zarate AN, Mendoza-Oliva A, Kashmer OM, Collazo-Lopez JE, White CL 3rd, Diamond MI. J Biol Chem. 2022 Jun 11:102132. doi: 10.1016/j.jbc.2022.102132. Online ahead of print.
The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics
Wickramaratne AC, Li L, Hopkins JB, Joachimiak LA, Green CB. Biochemistry. 2022 May 10. doi: 10.1021/acs.biochem.2c00072. Online ahead of print.
The dual fates of exogenous tau seeds: Lysosomal clearance versus cytoplasmic amplification
Kolay S, Vega AR, Dodd DA, Perez VA, Kashmer OM, White CL 3rd, Diamond MI. J Biol Chem. 2022 May 5;298(6):102014. doi: 10.1016/j.jbc.2022.102014. Online ahead of print.
VCP suppresses proteopathic seeding in neurons
Zhu J, Pittman S, Dhavale D, French R, Patterson JN, Kaleelurrrahuman MS, Sun Y, Vaquer-Alicea J, Maggiore G, Clemen CS, Buscher WJ, Bieschke J, Kotzbauer P, Ayala Y, Diamond MI, Davis AA, Weihl C, Mol Neurodegener 2022 Apr 17 1 30
Chaperoning shape-shifting tau in disease
Ryder BD, Wydorski PM, Hou Z, Joachimiak ŁA. Trends Biochem Sci. 2022 Apr;47(4):301-313. doi: 10.1016/j.tibs.2021.12.009.
Modifying Amyloid Motif Aggregation Through Local Structure
Bali S, Joachimiak LA. Methods Mol Biol. 2022; 2340:343-356. doi: 10.1007/978-1-0716-1546-1_15.
2021
Tau seeding in chronic traumatic encephalopathy parallels disease severity
Kaufman SK, Svirsky S, Cherry JD, McKee AC, Diamond MI. Acta Neuropathol. 2021 Dec;142(6):951-960. doi: 10.1007/s00401-021-02373-5.
Anatomic survey of seeding in Alzheimer's disease brains reveals unexpected patterns
Stopschinski BE, Del Tredici K, Estill-Terpack SJ, Ghebremdehin E, Yu FF, Braak H, Diamond MI. Acta Neuropathol Commun. 2021 Oct 11;9(1):164. doi: 10.1186/s40478-021-01255-x.
Deep learning reveals disease-specific signatures of white matter pathology in tauopathies
Vega AR, Chkheidze R, Jarmale V, Shang P, Foong C, Diamond MI, White CL, Rajaram S, Acta Neuropathol Commun 2021 Oct 9 1 170
Extensive rod and cone photoreceptor-cell degeneration in rat models of giant axonal neuropathy: implications for gene therapy of human disease
Armao D, Bouldin TW, Bailey RM, Gray SJ. Ophthalmic Genet vol. 42,5 (2021): 600-603. doi:10.1080/13816810.2021.1923036
DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation
Hou Z, Wydorski PM, Perez VA, Mendoza-Oliva A, Ryder BD, Mirbaha H, Kashmer O,Joachimiak, LA. Nat Commun. 2021 Sep 9;12(1):5338. doi: 10.1038/s41467-021-25635-y.
Biophysical properties of a tau seed
Hou, Z, Chen, D, Ryder, BD, Joachimiak, L. Sci Rep 11, 13602 (2021). doi: 10.1038/s41598-021-93093-z
AAV9-mediated FIG4 delivery prolongs life span in Charcot-Marie-Tooth disease type 4J mouse model
Presa M, Bailey RM, Davis C, Murphy T, Cook J, Walls R, Wilpan H, Bogdanik L, Lenk GM, Burgess RW, Gray SJ, Lutz C. J Clin Invest. 2021 Jun 1;131(11):e137159. doi: 10.1172/JCI137159.
Ultrasensitive tau biosensor cells detect no seeding in Alzheimer's disease CSF
Hitt BD, Vaquer-Alicea J, Manon VA, Beaver JD, Kashmer OM, Garcia JN, Diamond MI. Acta Neuropathol Commun. 2021 May 26;9(1):99. doi: 10.1186/s40478-021-01185-8.
Gene Transfer Therapy for Neurodevelopmental Disorders
Ozlu C, Bailey RM, Sinnett S, Goodspeed KD. Dev Neurosci. 2021 ;43(3-4):230-240. doi: 10.1159/000515434.
Tau strains shape disease
Vaquer-Alicea, J, Diamond, MI, Joachimiak, L. Acta Neuropathol 2021. doi: 10.1007/s00401-021-02301-7.
Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone
Ryder, BD, Matlahov, I, Bali, S, Vaquer-Alicea, J, van der Wel, PCA, Joachimiak, L. Nat Commun 2021 12, 946. doi:10.1038/s41467-021-21147-x
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2020
Alzheimer's disease risk modifier genes do not affect tau aggregate uptake, seeding or maintenance in cell models
Kolay S, Diamond MI. FEBS Open Bio. 2020 Sep;10(9):1912-1920. doi: 10.1002/2211-5463.12928.
Comparison of high-dose intracisterna magna and lumbar puncture intrathecal delivery of AAV9 in mice to treat neuropathies
Bailey RM, Rozenberg A, Gray SJ. Brain Research vol. 1739 (2020): 146832. doi:10.1016/j.brainres.2020.146832.
A synthetic heparinoid blocks Tau aggregate cell uptake and amplification
Stopschinski BE, Thomas TL, Nadji S, Darvish E, Fan L, Holmes BB, Modi AR, Finnell JG, Kashmer OM, Estill-Terpack S, Mirbaha H, Luu HS, Diamond MI. J Biol Chem. 2020 Mar 6;295(10):2974-2983. doi: 10.1074/jbc.RA119.010353.
The inhibition of cellular toxicity of amyloid-β by dissociated transthyretin
Cao Q, Anderson DH, Liang WY, Chou J, Saelices L J Biol Chem 2020; 295, 12015-14024. doi: 10.1074/jbc.RA120.013440
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2019
Propagation of Protein Aggregation in Neurodegenerative Diseases
Vaquer-Alicea J, Diamond MI. Annu Rev Biochem. 2019 Jun 20;88:785-810. doi: 10.1146/annurev-biochem-061516-045049.
Tau local structure shields an amyloid-forming motif and controls aggregation propensity
Chen D, Drombosky KW, Hou Z, Sari L, Kashmer OM, Ryder BD, Perez VA, Woodard DR, Lin MM, Diamond MI, Joachimiak LA. Nat Commun. 2019 Jun 7;10(1):2493. doi: 10.1038/s41467-019-10355-1.
2018
Tau monomer encodes strains
Sharma A, Thomas TL, Woodard DR, Kashmer OM, Diamond, MI.
eLife vol. 7 e37813. 11 Dec. 2018, doi:10.7554/eLife.37813.
Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART
Kaufman SK, Del Tredici K, Thomas TL, Braak H, Diamond MI. Acta Neuropathol. 2018 Jul;136(1):57-67. doi: 10.1007/s00401-018-1855-6.
Inert and seed-competent tau monomers suggest structural origins of aggregation
Mirbaha H, Chen D, Morazova OA, Ruff KM, Sharma AM, Liu X, Goodarzi M, Pappu RV, Colby DW, Mirzaei H, Joachimiak LA, Diamond MI. Elife. 2018 Jul 10;7. pii: e36584. doi: 10.7554/eLife.36584.
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Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates
Stopschinski BE, Holmes BB, Miller GM, Manon VA, Vaquer-Alicea J, Prueitt WL, Hsieh-Wilson LC, Diamond MI. J Biol Chem. 2018 Jul 6;293(27):10826-10840. doi: 10.1074/jbc.RA117.000378.
Development of Intrathecal AAV9 Gene Therapy for Giant Axonal Neuropathy
Bailey RM, Armao D, Nagabhushan Kalburgi S, Gray SJ. Mol Ther Methods Clin Dev. 2018 Feb 15;9:160-171. doi: 10.1016/j.omtm.2018.02.005.
2017
FRET and Flow Cytometry Assays to Measure Proteopathic Seeding Activity in Biological Samples
Furman JL, Diamond MI. Methods Mol Biol. 2017;1523:349-359.
2016
Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo
Kaufman SK, Sanders DW, Thomas TL, Ruchinskas AJ, Vaquer-Alicea J, Sharma AM, Miller TM, Diamond MI. Neuron. 2016 Nov 23;92(4):796-812. doi: 10.1016/j.neuron.2016.09.055.
Autonomic nervous system involvement in the giant axonal neuropathy (GAN) KO mouse: implications for human disease
Armao D, Bailey RM, Bouldin TW, Kim Y, Gray SJ. Clin Autonom Res 2016 Aug;26(4):307-13. doi: 10.1007/s10286-016-0365-7.
2015
Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry
Furman JL, Holmes BB, Diamond MI. J Vis Exp. 2015 Dec 8;(106):e53205. doi: 10.3791/53205.
Photo-activatable Cre recombinase regulates gene expression in vivo
Schindler SE, McCall JG, Yan P, Hyrc KL, Li M, Tucker CL, Lee JM, Bruchas MR, Diamond MI. Sci Rep. 2015 Sep 9;5:13627. doi: 10.1038/srep13627.
Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake
Funk KE, Mirbaha H, Jiang H, Holtzman DM, Diamond MI. J Biol Chem. 2015 Aug 28;290(35):21652-62. doi: 10.1074/jbc.M115.657924.
Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation
Mirbaha H, Holmes BB, Sanders DW, Bieschke J, Diamond MI. J Biol Chem. 2015 Jun 12;290(24):14893-903. doi: 10.1074/jbc.M115.652693.