Psychiatry Neuroscience Labs
Working with investigators to perform a broad battery of behavioral tests in both rats and mice
Setting up gene methodologies (viral vectors) in animals as a neuroscience tool and potential gene therapy for rare childhood neurological disorders; interested in animal models of chronic pain
Investigating spinal cord pathways that mediate pain and touch and how they interact with emotionally relevant brain regions to influence positive and negative moods
Combining tools from cognitive neuroscience, psychiatry & developmental psychology to elucidate the brain circuits and mechanisms supporting language & cognition in humans
Experimenting with blood-based biomarkers for diagnostic tests in clinical care; investigating immunohistochemical disturbances in a thalamic brain region involved in essential tremor
Gospocic Lab: Epigenetic Regulation of Social Brain
Studying how epigenetic pathways and gene expression regulate brain plasticity in the context of social behavior and aging by working with a unique ant species
Examining functional excitatory synaptic changes across behavioral arousal states including sleep deprivation and anesthesia
Focusing on function of the hippocampus in learning and memory, studying the role of the entorhinal cortex and its circuits in modifying hippocampal function and temporal memory
Exploring cellular and synaptic memories encoded by experience-induced gene programs, under-standing their roles in behaviors and perturbations in neurodevelop-mental and psychiatric disorders
Studying the role of double stranded DNA breaks in chromatin dynamics and how this regulates gene expression involved in learning, memory, and neuropsychiatric disease (e.g., addiction)
Psychiatry Imaging Facility
Focusing on neuronal circuit connectivity and working to support investigators to perform imaging and tissue dissection
Investigating the neural mechanisms of reward and punishment and their links to mental illnesses, such as depression and addiction
Schizophrenia/Tamminga Research Lab
Focusing on biomarkers of psychotic illness from individuals with psychosis and animal models and psychosis across the life-span and analyzing biomarker databases
Focusing on the neural dynamics for successful memory access and retrieval during episodic working memory tasks to elucidate the neural circuit mechanism in the hippocampal-cortical network
- Our Recent Publications
RNAi Knockdown of EHMT2 in Maternal Expression of Prader-Willi Syndrome Genes
Zaric V, Kang HR, Rybalchenko V, Zigman JM, Gray SJ, Butler RK.
Genes (Basel). 2024;15(11):1366. doi: 10.3390/genes15111366.Schizophrenia pathology reverse-translated into mouse shows hippocampal hyperactivity, psychosis behaviors and hyper-synchronous events
Scott DS, Subramanian M, Yamamoto J, Tamminga CA.
Mol Psychiatry. 2024. doi: 10.1038/s41380-024-02781-5.Psychosis Risk With Prescription Amphetamine
Tamminga CA.
Am J Psychiatry. 2024;181(10):856-7. doi: 10.1176/appi.ajp.20240732.Upregulated solute-carrier family genes in the hippocampus of schizophrenia can be rescued by antipsychotic medications.
Liu Z, Sun YH, Ren Y, Perez JM, Scott D, Tamminga C.
Schizophr Res. 2024;272:39-50. doi: 10.1016/j.schres.2024.08.012.