Clinical Research Labs
Center for Depression Research and Clinical Care
Bringing better understanding of the causes of depression, identifying effective new treatments, and improving existing treatments
Brown Lab: Psychoneuroendocrine Research Program
Psychoneuroendocrine research program focusing on substance abuse, dual diagnoses, and effects of corticosteroids on mood and memory
Coughlin Lab: Brain Health Program
Brain Health Program researching molecular neuroimaging techniques, particularly the use of novel radiotracers with positron emission tomography
North Texas Concussion Registry
Researching concussion diagnosis, prognosis, and treatment through comprehensive longitudinal data on sports-related concussions and other mild traumatic brain injury across the lifespan, with an emphasis on adolescent sport-related injuries
Developing analytical methods to integrate microbiome data with neuroimaging, behavioural, and clinical data sets to better understand the individual nature of microbiome-host interactions in health and disease
Schizophrenia/Tamminga Research Lab
Investigating neurobiological mechanisms of schizophrenia and related disorders and developing human in vivo biomarkers for psychotic disorders, primarily using cognition and multimodal brain imaging measures
Jarrett Lab: Psychosocial Research
Evaluating the role of psychosocial factors and interventions on the course of health in mood and related disorders
LoBue Lab: Brain Aging, Injury, and Modulation
Brain aging, injury, and modulation: investigating later-in-life effects of traumatic brain injury and studying effects of noninvasive brain stimulation in Alzheimer’s disease and related disorders
Focusing on functional neuro-imaging studies to examine the connection between biological, psychological, and social aspects of eating disorders
Interventional Psychiatry Research Program
Furthering the development and utility of neurotherapeutic interventions for use in scientific investigations and clinical practice
Focusing on improving cognition in older adults with or at risk for dementia through brain stimulation, with cognitive, functional, and pharmacological modalities
Schizophrenia/Tamminga Research Lab
Investigating the nature and treatment of cognitive deficits commonly seen in schizophrenia and related disorders
Establishing antidepressant treatment efficacy, examining treatment-resistant depression to develop algorithms and guidelines, developing and validating biomarkers to reach the goal of precision medicine for mood disorders
- Our Recent Publications
Genetic analysis of psychosis Biotypes: shared Ancestry-adjusted polygenic risk and unique genomic associations.
Xia C, Alliey-Rodriguez N, Tamminga CA, Keshavan MS, Pearlson GD, Keedy SK, Clementz B, McDowell JE, Parker D, Lencer R, Hill SK, Bishop JR, Ivleva EI, et al.
Mol Psychiatry. 2024. doi: 10.1038/s41380-024-02876-z.Race/ethnicity, sex, and age differences in pediatric SCAT-5 concussion symptoms.
Bunt SC, Silver CH, Shurtz L, Allen TT, Didehbani N, Hicks C, Chowdhury S, Wilmoth K, Hynan LS, Stokes M, Miller SM, Bell K, Cullum CM.
Appl Neuropsychol Child. 2024. doi: 10.1080/21622965.2024.2441490.Relationship between self-reported concussion history, cognition, and mood among former collegiate athletes.
Datoc A, Sanders GD, Tarkenton Allen T, Schaffert J, Didehbani N, Cullum CM.
Clin Neuropsychol. 2024. doi: 10.1080/13854046.2024.2440113.Neuronal viability/astrocyte activity ratio in the dorsolateral prefrontal cortex as a biomarker of Alzheimer's dementia: a proton magnetic resonance spectroscopy study.
Jha S, Torres-Carmona E, Iwata Y, Ma C, Graff-Guerrero A, Fischer CE, Mulsant B, Pollock BG, Rajji TK, et al.
Cereb Cortex. 2024;34(11):bhae465.Problematic Substance Use in Depressed Youth: Associations with Suicidal Ideation and Suicide Attempt History
Armstrong GM, Anderberg JL, Gorman AR, Spencer SD, Minhajuddin A, Ecker AH, Spofford J, Guzick AG, Slater H, Aloor FZ, Flores AM, Lagrone JM, Marino EN, Soutullo CA, Wakefield SM, Goodman WK, Trivedi MH, et al.
J Dual Diagn. 2024. doi: 10.1080/15504263.2024.2434219.Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment: A Randomized Clinical Trial
Rajji TK, et al.
JAMA Psychiatry. 2024 Oct 30:e243241. doi: 10.1001/jamapsychiatry.2024.3241.The relationship between asthma and suggested alcohol dependence and heavy alcohol use in the Cooper Center longitudinal study: The role of depressive symptom severity
Agarwal CD, Shuval K, Li Q, DeFina LF, Barlow CE, Khan DA, Brown ES.
J Affect Disord. 2024;370:356-61. doi: 10.1016/j.jad.2024.11.004.First responders have it covered
Green M, Foster JA.
Science. 2024;386(6721):497-498.Concurrent and prospective prediction of community-dwelling adults' psychosocial functioning with the Inventory of Depression and Anxiety Symptoms-II (IDAS-II)
Vittengl JR, Ro E, Jarrett RB, et al.
Psychol Assess. 2024. doi: 10.1037/pas0001347.Modulation of neural oscillations in escitalopram treatment: a Canadian biomarker integration network in depression study.
Schwartzmann B, Chatterjee R, Vaghei Y, Quilty LC, Allen TA, Arnott SR, Atluri S, Blier P, Dhami P, Foster JA, et al.
Transl Psychiatry. 2024;14(1):432. doi: 10.1038/s41398-024-03110-8.Endocannabinoid concentrations in major depression: effects of childhood maltreatment and relation to hippocampal volume
Mazurka R, Harkness KL, Hassel S, Stensson N, Nogovitsyn N, Poppenk J, Foster JA, et al.
Transl Psychiatry. 2024;14(1):431. doi: 10.1038/s41398-024-03151-z.Microbes and mood: innovative biomarker approaches in depression
Green M, Trivedi MH, Foster JA.
Trends Mol Med. 2024 Sep 30:S1471-4914(24)00241-7. doi: 10.1016/j.molmed.2024.09.002.Electroconvulsive therapy and cognitive performance from the Global ECT MRI Research Collaboration
Kiebs M, Farrar DC, Yrondi A, Cardoner N, Tuovinen N, Redlich R, Dannlowski U, Soriano-Mas C, Dols A, Takamiya A, Tendolkar I, Narr KL, Espinoza R, Laroy M, van Eijndhoven P, Verwijk E, van Waarde J, Verdijk J, Maier HB, Nordanskog P, van Wingen G, van Diermen L, Emsell L, Bouckaert F, Repple J, Camprodon JA, Wade BSC, Donaldson KT, Oltedal L, Kessler U, Hammar Å, Sienaert P, Hebbrecht K, Urretavizcaya M, Belge JB, Argyelan M, Baradits M, Obbels J, Draganski B, Philipsen A, Sartorius A, Rhebergen D, Ousdal OT, Hurlemann R, McClintock S, et al.
J Psychiatr Res. 2024;179:199-208. doi: 10.1016/j.jpsychires.2024.09.013.EEG measures of brain arousal in relation to symptom improvement in patients with major depressive disorder: Results from a randomized placebo-controlled clinical trial
Ulke C, Kayser J, Tenke CE, Mergl R, Sander C, Panier LY, Alvarenga JE, Fava M, McGrath PJ, Deldin PJ, McInnis MG, Trivedi MH, et al.
Psychiatry Res. 2024;342:116165. doi: 10.1016/j.psychres.2024.116165.The gut-brain axis in depression: Are multi-omics showing the way?
Foster JA, Trivedi MH.
Cell Rep Med. 2024;5(9):101741. doi: 10.1016/j.xcrm.2024.101741.The physical activity in cancer survivors (PACES) trial: a factorial randomized trial to optimize intervention for breast cancer survivors.
Rethorst CD, Carmody TJ, Argenbright KE, Vazquez L, DeLuca T, Mayes TL, Hamann HA, Trivedi MH.
J Behav Med. 2024. doi: 10.1007/s10865-024-00518-x.Clinical and sociodemographic features of the Texas resilience against depression (T-RAD) study: Findings from the initial cohort.
Trivedi MH, Jha MK, Elmore JS, Carmody T, Chin Fatt C, Sethuram S, Wang T, Mayes TL, Foster JA, Minhajuddin A.
J Affect Disord. 2024;364:146-156. doi: 10.1016/j.jad.2024.08.006.Longitudinal prediction of psychosocial functioning outcomes: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Section-II personality disorders versus alternative model personality dysfunction and traits
Clark LA, Ro E, Vittengl JR, Jarrett RB.
Personal Disord. 2024;15(5):341-351. doi: 10.1037/per0000673.Substance use patterns and mental health comorbidities in youth with a history of depression or suicidality: Findings from TX-YDSRN.
Clark SL, Dodd CG, Mitchell TB, Ingram SJ, Armstrong GM, Jha MK, Soares JC, Smith M, Minhajuddin A, Slater H, Wakefield SM, Trivedi MH.
J Affect Disord. 2024;366:210-216. doi: 10.1016/j.jad.2024.08.128.Measurement invariance of the Screen for Child Anxiety Related Emotional Disorders (SCARED) across ethnicity, age, and sex among youth with depression.
Silva T, Spencer SD, Higham M, Castillo AA, Minhajuddin A, Gorman A, Goodman LC, Pinciotti CM, Hernandez S, Slater H, Soutullo CA, Hettema JM, Azhar NA, Goodman WK, Trivedi MH, et al.
Personalized Medicine in Psychiatry. 2024;47-48.