Phase VIII – Pre-clinical Studies
Researchers studied the effects of cholinesterase-inhibiting chemicals on the brain in a laboratory rodent model of Gulf War illness (2009-2010).
A. Studies in a rodent model of Gulf War illness
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Development of the rodent model of Gulf War illness [References]
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Neuronal signal transduction (Bibb) [References]
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Cholinergic signaling (Cooper) [References]
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Mitochondrial calcium metabolism (Bezprozvanny)
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Hippocampal synaptic transmission [References]
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ALS mouse model (Elliott) [References]
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Glioblastoma model (Bachoo)
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Autonomic nervous system model (Vernino) [References]
C. Demonstrated that gene therapy to boost serum PON1 isoenzymes protects rats from organophosphate toxicity. [References]