Phase V: Brain-Testing Studies, National Sample
Researchers next applied the novel brain-testing technology to a representative sample of Gulf War-era veterans (2007-2015).
A. U.S. Military Health Survey in a large representative sample of Gulf War-era veterans [References]
B. Clinical neurological studies demonstrating autonomic dysfunction in the national sample of Gulf War veterans [References]
C. Cholinergic-challenge experiment showing abnormal cholinergic brain function
D. Neuroimaging studies showing objective brain abnormalities in ill veterans
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Arterial spin labeling and SPECT neuroimaging (Briggs/Li)
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Magnetic resonance spectroscopy (MRS) (Briggs/Cheshkov) [References]
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Diffusion tensor imaging (McColl)
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Quantitative sensory fMRI (Gopinath)
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Functional connectivity fMRI (Gopinath)
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Emotional memory circuits fMRI (Kraut/Ringe)
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Material-specific encoding memory fMRI (Ringe)
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Attention and executive function fMRI (Rypma)
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Word retrieval fMRI (Hart)
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Auditory and visual memory fMRI (Odegard)
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Complex verbal functions fMRI (Crosson)
E. EEG studies show objective brain abnormalities in ill veterans
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Resting EEG
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Functional EEG of hyperarousal
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Functional EEG with visual threat to differentiate from PTSD
F. Neuropsychological testing (Hart/Cullum)
Phase V was funded by an IDIQ research contract from the Department of Veterans Affairs.