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Unravelling Autism • Preston Wiles M.D. • Professor, UTSWMC • Senior Attending, Autism Center Learning Objectives • Describe essential features of autism spectrum disorders • Overview of genetic factors in the disorder • Understand brain function related to core features of autism • Review features of epidemiology-is there an epidemic or not • Role of science/education vs. Myth/meme Autism Spectrum Disorders • Autistic Disorder • Pervasive Developmental

Dissecting the Role of MeCP2 in Brain & Implications for Autism Spectrum Disorders Lisa M. Monteggia, Ph.D. Department of Psychiatry UT Southwestern Medical Center, Dallas, TX Autism • Twin studies examining the concordance of autism spectrum disorders for identical twins, compared to fraternal twins or siblings, indicates a strong genetic component. • Many genes have been associated with autism, but each has been found in only a few individuals. • No single

? "@ Understanding Cellular Systems Using Genome Data Kim Reynolds, UT Southwestern, Sept. 2014 Why is this problem hard?! ! Detailed knowledge of the molecular players…! an apparently dense, interconnected network.! Why is this problem hard?! ! Detailed knowledge of the molecular players…! an apparently dense, interconnected network.! ! A complex biological system. what do we mean by complex? Hillenmeyer, ME et al. (2008) Science 320, p 5874 gene essentiality in yeast for ~5000

The Science & Epidemiology of Adolescent Poisonings Greene Shepherd, PharmD., DABATGreene Shepherd, PharmD., DABAT Managing Director & Clinical Assistant ProfessorManaging Director & Clinical Assistant Professor North Texas Poison Center & North Texas Poison Center & UTSW Division of Emergency MedicineUTSW Division of Emergency Medicine What Makes a Poison? •• The odor?The odor? •• The taste?The taste? •• The color?The color? •• The substance?The substance? –– Arsenic Arsenic vsvs

Fundamentals of Investigating Epidemics Robert W. Haley, M.D. Professor of Internal Medicine Chief, Epidemiology Division University of Texas Southwestern Medical Center Dallas, Texas Epidemic Curve of a Typical Common Source Outbreak: 1976 Outbreak of Fatal Pneumonia in Attendees at a Conference of American Legionnaires Steps in the Investigation of an Epidemic 1. Prepare for field work. 2. Establish the existence of an outbreak 3. Verify the diagnosis 4. Define and identify cases 5

Better Living Through ChemistryBetter Living Through Chemistry Kurt C. Kleinschmidt, M.D.Kurt C. Kleinschmidt, M.D. Associate Professor of SurgeryAssociate Professor of Surgery Division of Emergency MedicineDivision of Emergency Medicine Faculty, Section of ToxicologyFaculty, Section of Toxicology University of Texas Southwestern Medical CenterUniversity of Texas Southwestern Medical Center Associate Medical Director, Emergency DepartmentAssociate Medical Director, Emergency Department

Medical ImagingMedical Imaging Gary Gary ArbiqueArbique, Ph.D., Ph.D. UTSW Medical Physics DivisionUTSW Medical Physics Division Medical Imaging Time LineMedical Imaging Time Line •• 1895 1895 -- First xFirst x--ray image of human handray image of human hand •• 1914 1914 -- First practical fluoroscopeFirst practical fluoroscope •• 1924 1924 -- BlumgartBlumgart & de & de HevesyHevesy perform first perform first clinical tracer studiesclinical tracer studies •• 1948 1948 –– Fluoroscopic