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1 : 0 0 - 5 : 0 0 P. M . I N T RODUC T I ON 1 : 0 0 P. M . F E AT UR ED S P E A K E R S : September 11, 2014 HAO TANG, PH.D. Clinical Sciences Precision Medicine in the Era of Big Data XIAOWEI ZHAN, PH.D. Clinical Sciences, Center for Genetics of Host Defense Finding Matched Controls for Targeted Sequencing Experiments HONG ZHU, PH.D. Clinical Sciences, Simmons Comprehensive Cancer Center Statistical Considerations on Design of Historical Control Trials DAWN WETZEL, M.D., PH.D. Pediatrics

September 16, 2015 DAVID MCFADDEN, M.D., PH.D. Internal Medicine, Biochemistry Simple Cancer Genomes and the Search for Selective Cancer Toxins JAMES COLLINS, PH.D. Pharmacology It’s No Fluke! Using Planarians to Guide Our Understanding of Parasitic Schistosomes DOUGLAS STRAND, PH.D. Urology Cell and Molecular Biology of Benign Prostatic Hyperplasia MIKE HENNE, PH.D. Cell Biology, Biophysics Inter-organelle Contact Sites in Lipid Metabolism, Aging, and Neurological Disease YINGFEI WANG

September 14, 2021 UT Southwestern Medical School a n d UT Southwestern Graduate School of Biomedical Sciences p r e s e n t t h e This Event will be Virtual BRE A K C LO S I NG R EMARK S 2:25 - 2:45 P.M. ONI N T RODUC T I XIAOCHUN LI, PH.D. Center for Human Nutrition Fluxomics Analysis of Hepatic Lipid Remodeling ESRA AKBAY, PH.D. Internal Medicine Defining Protective Metabolic Adaptation in States of Inflammation FEATURED SPEAKERS: Forum Research Faculty New 2 0

A: Whole-mount preparation of osseous lamina (OSL) and basilar membrane at a level of focus that shows a vessel (horizontal arrow) emerging from the OSL and joining the spiral vessel (vertical arrows) under the basilar membrane. B: Scanning micrograph showing a similar situation in which a vessel (horizontal arrow) emerges from the OSL to join the spiral vessel (vertical arrows). As in the preceding micrograph (#32), the spiral vessel under the basilar membrane appears exposed to the

Scanning electron micrograph of the spiral ligament beneath the attachment of the basilar membrane to the lateral cochlear wall (the attachment zone of the basilar membrane is indicated by the dotted line at upper left). As in Figure 26, note the porous, mesh-like texture of the spiral ligament. In the region shown here three blood vessels (arrows) are seen coursing very near the surface of the spiral ligament.

Scanning electron microscopic view of the surface of the spiral ligament in the area immediately below the attachment of the basilar membrane. (The site of attachment of the basilar membrane to the lateral wall tissues in indicated by the dotted line.) Note the highly porous, mesh-like structure of the spiral ligament surface. From Roland PS, Wright C.G. Surgical aspects of cochlear implantation: Mechanisms of insertional trauma. Adv Otorhinolaryngol 2006;64:11-30. Copyright S. Karger

Cross section of the posterior spiral vein (arrow) in the basal turn. In this location the vein has virtually no bony covering. ST, scala tympani; MD modiolus.

Lower basal cochlear turn showing the common modiolar vein as it enters the cochlear aqueduct (arrow). The white arrow indicates the vestibulocochlear vein which joins the common modiolar vein. ST, floor of scala tympani.

Cochlear cross section showing a vein (arrow) traversing the floor of scala tympani and approaching the posterior spiral vein. The vein has no bony covering.

A: Cross section of a vein (arrow) on the floor of scala tympani. Note that it has only a thin connective tissue covering. B: Longitudinal section of a vein (arrows) on floor of scala tympani. The vessel appears completely exposed to the perilymphatic space.