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UT Southwestern Medical Center at Dallas Graduate School of Biomedical Sciences Doctor of Philosophy (Ph.D.) in Molecular Biophysics / Average Number of Degrees per Year 8 Graduation Rates 100% of students who earned PhDs have done so in less than 10 years Average Time to Degree 5.7 years Employment Profile (1) 17 employed in field (85%) 1 going to law school post-PhD (5%) 1 out of science (5%) 1 unknown (5%) Admissions Criteria The following criteria are used in evaluating each

Protein Structure Determination An Introduction Chad A. Brautigam, Ph.D. Structural Biology Laboratory UTSW Medical Center at Dallas What is “Protein Structure?” …Arg-Lys-Ala-Gln-Trp-Cys-His-Ala-Asp… What is “Protein Structure?” • It is the description of the three- dimensional architecture of a polypeptide. • Our aim: to know accurately and precisely the position of every atom in a protein. That’s usually between 2000 and 10,000 atoms! Wherefore Art Thou, Protein

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Microarrays Ralph V. Shohet, M.D. Department of Internal Medicine, UTSWMC Outline 1. Types of microarrays 2. How to make one 3. How to use one Historical perspective 1. Watson-Crick basepairing 2. Southern & Northern analysis 3. Genome project Types of microarrays 1. Synthesized in situ 2. Spotted Types of microarrays 1. Synthesized in situ Short oliogonucleotides (25mers) masked and DOC particularly useful for interrogating small regions of a gene for sequence

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DR. WOODRING E. WRIGHT BIOLOGY OF AGING Learning objectives: At the completion of the lecture, you should be able to: 1. 2. 3. 4. 5. 6. 7. 8. 9. Define antagonistic pleiotropy Give the rationale for why the “disposable soma” theory of aging can be treated as an example of antagonistic pleiotropy Name four premature aging syndromes, two of which are known to affect DNA repair enzymes Describe why patients with diabetes are thought to show accelerated aging of

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The Science & Epidemiology of Adolescent Poisonings Greene Shepherd, PharmD., DABATGreene Shepherd, PharmD., DABAT Managing Director & Clinical Assistant ProfessorManaging Director & Clinical Assistant Professor North Texas Poison Center & North Texas Poison Center & UTSW Division of Emergency MedicineUTSW Division of Emergency Medicine What Makes a Poison? •• The odor?The odor? •• The taste?The taste? •• The color?The color? •• The substance?The substance? –– Arsenic Arsenic vsvs