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Skeletal Muscle and Aging: Going, Going, Gone National Science Teachers Association 53rd National Convention April 2, 2005 20 yr 80 yr (http://www.sarcopenia.com/) Conditions Leading to Muscle Wasting (Atrophy) • Limb immobilization (casting) • Microgravity • Prolonged bed rest/hindlimb suspension • Tumor bearing • Fasting/malnutrition • Burns • Infection • Denervation • Sarcopenia Sarcopenia “No decline with age is more dramatic or potentially more functionally significant that

UT Southwestern to expand cancer care in Fort Worth with a state-of-the-art Radiation Oncology facility

1 www4.utsouthwestern.edu/FrederickGrinnell/hsinteract.htm Teaching Bioethics to High School Students Ethics,morals,law Ethics Greek: ethos, character Morals Latin: moralis, custom Law Old English: lagu, laid down 2 Some Theories Focus on the Elements of Human Behavior Actor  Action  Outcome Actor - Character Action - Obligations Outcome - Consequences Universal Approaches to Ethical-Decision Making Situation evaluated according to general theories, principles, or

Osmosis and Osmoregulation Robert Alpern, M.D. Southwestern Medical School Water Transport Across Semipermeable Membranes • In a dilute solution, Jv = Lp (∆P - RΤ∆CS ) • Jv - volume or water flux • Lp - hydraulic conductivity or permeability • ∆P - hydrostatic pressure gradient • R - gas constant • T - absolute temperature (Kelvin) • ∆Cs - solute concentration gradient Osmotic Pressure • If Jv = 0, then ∆P = RT∆Cs van’t Hoff equation ∆Π

Obesity A Review for Teachers Outline • The prevalence of obesity & associated medical problems has increased greatly in the US, both among adults & children. • The causes are complex. • Controlling obesity by exercise & diet is difficult. • Drug therapy is not very effective. Surgery may be necessary for severe obesity. How Do We Define Overweight & Obesity? • In adults, obesity is defined by the BMI (Body Mass Index), which is the weight in kilograms divided by height in

ß-Lapachone, a ‘Kiss of death’ therapy for cancer David A. Boothman, Ph.D. Laboratory of Molecular Stress Responses Program in Cell Stress and Cancer Nanomedicine Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center at Dallas September 14, 2008 Cellular Damage New Gene Expression Exploitable Target: Expressed in Human Tumors, not (or low) in Normal Tissues Bioactivate Drug For Tumor-Selective Killing -Not cell cycle

TYPE 2 DIABETES MELLITUS:TYPE 2 DIABETES MELLITUS: NEW HOPE FOR PREVENTIONNEW HOPE FOR PREVENTION Robert Dobbins, M.D. Ph.D.Robert Dobbins, M.D. Ph.D. Learning ObjectivesLearning Objectives Recognize current trends in the Recognize current trends in the prevalence of type 2 diabetes.prevalence of type 2 diabetes. Learn differences between type 1 Learn differences between type 1 and type 2 diabetes.and type 2 diabetes. List risk factors for type 2 diabetes.List risk factors for type 2

Introduction to Proteins and Enzymes • Basics of protein structure and composition • The life of a protein • Enzymes – Theory of enzyme function – Not all enzymes are proteins / not all proteins are enzymes – Enzyme REGULATION • Setting up an enzyme assay – Buffer, cofactors, substrate, enzyme Why are Proteins Important? • Major class of catalysts in the cells; responsible for metabolism • Proteins interconvert energy • Proteins permit selective import and export of molecules from