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Unravelling Autism • Preston Wiles M.D. • Professor, UTSWMC • Senior Attending, Autism Center Learning Objectives • Describe essential features of autism spectrum disorders • Overview of genetic factors in the disorder • Understand brain function related to core features of autism • Review features of epidemiology-is there an epidemic or not • Role of science/education vs. Myth/meme Autism Spectrum Disorders • Autistic Disorder • Pervasive Developmental

Biotechnology in the Post- Genomic Age STARS Inservice on Biotechnology February 4, 2006 Joel M. Goodman, Ph.D. Supporting Cast  STARS support  Ms. Jeannie Han  Ms. Traydell Beard  Goodman lab support  Dr. Derk Binns  Ms. Kimberly Szymanski Activity 1: PCR  We’ll start this now, talk more later  You will be amplifying a yeast gene (one of five different genes) using the polymerase chain reaction.  6 groups, 4 teachers to a group  By the end of the day, you will identify

Dissecting the Role of MeCP2 in Brain & Implications for Autism Spectrum Disorders Lisa M. Monteggia, Ph.D. Department of Psychiatry UT Southwestern Medical Center, Dallas, TX Autism • Twin studies examining the concordance of autism spectrum disorders for identical twins, compared to fraternal twins or siblings, indicates a strong genetic component. • Many genes have been associated with autism, but each has been found in only a few individuals. • No single

Skeletal Muscle and Aging: Going, Going, Gone National Science Teachers Association 53rd National Convention April 2, 2005 20 yr 80 yr (http://www.sarcopenia.com/) Conditions Leading to Muscle Wasting (Atrophy) • Limb immobilization (casting) • Microgravity • Prolonged bed rest/hindlimb suspension • Tumor bearing • Fasting/malnutrition • Burns • Infection • Denervation • Sarcopenia Sarcopenia “No decline with age is more dramatic or potentially more functionally significant that

Cases in employees 0 10 20 30 40 50 60 70 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 Day of onset (July) Cases 0 10 20 30 40 50 60 70 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 Employees Visitors Cases Day of onset (July) Cases in employees and visitors Secondary attack rate Cases in household members Total number of household members X 100 • Epidemiology: the study of diseases in populations • Epidemic: an unusual occurrence (a significant increase in

STARS A Valuable Resource for Health Science Teachers 2006 Health Science Technology Education Professional Development Conference July 19, 2006 Joel M. Goodman, Ph.D. Professor of Pharmacology STARS Director Today’s agenda Introduction to STARS Suture clinic What is STARS? • Science Teacher Access to Resources at Southwestern • Developed at UT Southwestern in 1991 to improve science teaching in north Texas. • Currently offer 17 programs and activities for secondary school

? "@ Understanding Cellular Systems Using Genome Data Kim Reynolds, UT Southwestern, Sept. 2014 Why is this problem hard?! ! Detailed knowledge of the molecular players…! an apparently dense, interconnected network.! Why is this problem hard?! ! Detailed knowledge of the molecular players…! an apparently dense, interconnected network.! ! A complex biological system. what do we mean by complex? Hillenmeyer, ME et al. (2008) Science 320, p 5874 gene essentiality in yeast for ~5000