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STARS A Valuable Resource for Health Science Teachers 2006 Health Science Technology Education Professional Development Conference July 19, 2006 Joel M. Goodman, Ph.D. Professor of Pharmacology STARS Director Today’s agenda Introduction to STARS Suture clinic What is STARS? • Science Teacher Access to Resources at Southwestern • Developed at UT Southwestern in 1991 to improve science teaching in north Texas. • Currently offer 17 programs and activities for secondary school

• Scan in photos of orcas feeding on great whales • Know there are lots of orcas in the north Pacific A Life without Oxygen: The Physiology of Marine Mammals <Picture> COMPETITION FOR RESOURCES How marine mammals do what they do! Dive Response • Stop Breathing • ↓ Cardiac Output • ↓ Peripheral Blood Flow • Lungs Collapse below 60m • But Maintain Aerobic Metabolism Adaptations to Maintain Aerobic Metabolism under Hypoxic

Osmosis and Osmoregulation Robert Alpern, M.D. Southwestern Medical School Water Transport Across Semipermeable Membranes • In a dilute solution, Jv = Lp (∆P - RΤ∆CS ) • Jv - volume or water flux • Lp - hydraulic conductivity or permeability • ∆P - hydrostatic pressure gradient • R - gas constant • T - absolute temperature (Kelvin) • ∆Cs - solute concentration gradient Osmotic Pressure • If Jv = 0, then ∆P = RT∆Cs van’t Hoff equation ∆Π

Skeletal Muscle and Aging: Going, Going, Gone National Science Teachers Association 53rd National Convention April 2, 2005 20 yr 80 yr (http://www.sarcopenia.com/) Conditions Leading to Muscle Wasting (Atrophy) • Limb immobilization (casting) • Microgravity • Prolonged bed rest/hindlimb suspension • Tumor bearing • Fasting/malnutrition • Burns • Infection • Denervation • Sarcopenia Sarcopenia “No decline with age is more dramatic or potentially more functionally significant that

Introduction to Proteins and Enzymes • Basics of protein structure and composition • The life of a protein • Enzymes – Theory of enzyme function – Not all enzymes are proteins / not all proteins are enzymes – Enzyme REGULATION • Setting up an enzyme assay – Buffer, cofactors, substrate, enzyme Why are Proteins Important? • Major class of catalysts in the cells; responsible for metabolism • Proteins interconvert energy • Proteins permit selective import and export of molecules from

Renal Structure and Function Sodium Transport Orson W. Moe, M.D. Department of Internal Medicine Division of Nephrology UTSouthwestern STARS Program organism world Maintain constancy Composition Quantity Afferent Sensor Efferent Effector Physiologic parameter Disease Excretion Endocrine Metabolism Renal Function Good stuff Bad stuff Endocrine hormone Metabolic substrate Gross anatomy Medulla (Pyramids) Capsule Medullary rays Cortex Major calyx Minor calyx Renal

MASS PROTEIN CHEMISTRY SPECTROMETRY TECHNOLOGY CENTER REQUISITION UTSWMC ND6.202; (214) 645-6300; (214) 645-6298 (fax) yli@biochem.swmed.edu Date Ordered: _____________________ Phone #: __________ Fax #: __________ Requested By: _____________________ Authorized Signature: _______________ Lab Room #: _____________________ Department: ______________________ Investigator: ______________________ PI: _______________________________ Sample Name Amt (pmol) Vol (µL) Est. Mwt (if known) Solution

EDMAN PROTEIN CHEMISTRY SEQUENCING TECHNOLOGY CENTER REQUISITION UTSWMC Y4.334; (214) 648 -5017; (214) 648-9477(fax) Bikash.Pramanik@UTSouthwestern.edu Date Ordered: _____________________ Phone #: __________ Fax #: __________ Requested By: _____________________ Authorized Signature: _______________ Lab Room #: _____________________ Department: ______________________ Investigator: ______________________ Acct #: ___________________________ No. Sample Name Amt (pmol) Est Mwt (if known) 1