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Anti-malarial Drug Discovery Jeffrey Baldwin, PhD UT Southwestern Medical Center Department of Pharmacology Malaria Burden Life Cycle Jones & Good, Nature Medicine (Feb. 2006) Complex life cycle Intracellular parasite Pathogenesis 4 Plasmodium species are human pathogens: Falciparum Vivax Ovale Malariae Miller et al, Nature (7 Feb, 2002) Clinical Outcomes Miller et al, Nature (7 Feb, 2002) Immune Evasion PfEMP1 is key to lethality of P. falciparum Sticky molecules evade

Cardiovascular Alterations Team Basic Science Clinical Science Mature Countermeasure Space Radiation Human Health and Countermeasures Cardiovascular Alterations Team Radiation, Endothelial Cell Senescence, Accelerated Aging, and Atherosclerosis PI. Art Shoukas, Ph.D. Johns Hopkins University Effect of high energy particle irradiation on adhesiveness of vascular endothelium and its consequences for atherosclerosis PI: Dennis Kucik, M.D. The University of Alabama at

Introduction to Proteins and Enzymes • Basics of protein structure and composition • The life of a protein • Enzymes – Theory of enzyme function – Not all enzymes are proteins / not all proteins are enzymes – Enzyme REGULATION • Setting up an enzyme assay – Buffer, cofactors, substrate, enzyme Why are Proteins Important? • Major class of catalysts in the cells; responsible for metabolism • Proteins interconvert energy • Proteins permit selective import and export of molecules from

Protein Structure Determination An Introduction Chad A. Brautigam, Ph.D. Structural Biology Laboratory UTSW Medical Center at Dallas What is “Protein Structure?” …Arg-Lys-Ala-Gln-Trp-Cys-His-Ala-Asp… What is “Protein Structure?” • It is the description of the three- dimensional architecture of a polypeptide. • Our aim: to know accurately and precisely the position of every atom in a protein. That’s usually between 2000 and 10,000 atoms! Wherefore Art Thou, Protein

WEIGHT REGULATION AND THE ROLE OF LEPTIN J. Denis McGarry, Ph.D. A portion of this outline has been taken, with permission, from a Medical Grand Rounds lecture on the genetics of obesity given by Rody Cox, M.D. at U.T. Southwestern, March 7, 1996. Obesity has become a world-wide epidemic, particularly in developed countries. It is associated with a number of serious morbidities, including Type 2 diabetes, osteoarthritis and hypertension. The current cost of obesity/Type 2 diabetes syndromes

Fall 2021 T H E P O W E R O F P H I L A N T H R O P Y Campaign for the Brain surpasses goal, drives investment in Peter O’Donnell Jr. Brain Institute Campus Paths Under a brilliant autumn sky, Eugene McDermott Plaza is the perfect spot to see the seasons change at the center of South Campus. Pathways is published by the Office of Development and Alumni Relations at UT Southwestern Medical Center. Pathways strives to offer current news about health topics of interest to our