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Osmosis and Osmoregulation Robert Alpern, M.D. Southwestern Medical School Water Transport Across Semipermeable Membranes • In a dilute solution, Jv = Lp (∆P - RΤ∆CS ) • Jv - volume or water flux • Lp - hydraulic conductivity or permeability • ∆P - hydrostatic pressure gradient • R - gas constant • T - absolute temperature (Kelvin) • ∆Cs - solute concentration gradient Osmotic Pressure • If Jv = 0, then ∆P = RT∆Cs van’t Hoff equation ∆Π

The Science & Epidemiology of Adolescent Poisonings Greene Shepherd, PharmD., DABATGreene Shepherd, PharmD., DABAT Managing Director & Clinical Assistant ProfessorManaging Director & Clinical Assistant Professor North Texas Poison Center & North Texas Poison Center & UTSW Division of Emergency MedicineUTSW Division of Emergency Medicine What Makes a Poison? •• The odor?The odor? •• The taste?The taste? •• The color?The color? •• The substance?The substance? –– Arsenic Arsenic vsvs

1 Cancer Cancer NanomedicineNanomedicine JinmingJinming GaoGao, Ph.D., Ph.D. Department of PharmacologyDepartment of Pharmacology Harold C. Simmons Comprehensive Cancer CenterHarold C. Simmons Comprehensive Cancer Center UT Southwestern Medical CenterUT Southwestern Medical Center Departments of Chemistry and BioengineeringDepartments of Chemistry and Bioengineering UT DallasUT Dallas 12,75612,756 kmkm NanomedicineNanomedicine in in PerspectivePerspective Mother EarthMother Earth 25.4

? "@ Understanding Cellular Systems Using Genome Data Kim Reynolds, UT Southwestern, Sept. 2014 Why is this problem hard?! ! Detailed knowledge of the molecular players…! an apparently dense, interconnected network.! Why is this problem hard?! ! Detailed knowledge of the molecular players…! an apparently dense, interconnected network.! ! A complex biological system. what do we mean by complex? Hillenmeyer, ME et al. (2008) Science 320, p 5874 gene essentiality in yeast for ~5000

Cardiovascular Alterations Team Basic Science Clinical Science Mature Countermeasure Space Radiation Human Health and Countermeasures Cardiovascular Alterations Team Radiation, Endothelial Cell Senescence, Accelerated Aging, and Atherosclerosis PI. Art Shoukas, Ph.D. Johns Hopkins University Effect of high energy particle irradiation on adhesiveness of vascular endothelium and its consequences for atherosclerosis PI: Dennis Kucik, M.D. The University of Alabama at

How Neurons Communicate at Synapses Jose Rizo-Rey White gives check mate in two moves Samuel Loyd 1859 So beautiful! Samuel Loyd 1859 OUR AMAZING BRAIN http://research.vtc.vt.edu/news/2013/feb/13/brain-awareness-week-designed-highlight-advances-b/ trauma.blog.yorku.ca arttattler.com Neurons are the key cells that make the brain so unique (drawings by Santiago Ramon y Cajal) https://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved

How is the brain influenced by radiation? Amelia J. Eisch, Ph.D. Department of Psychiatry, UT Southwestern October 3, 2009 Presenter Presentation Notes Here I will review the efforts of my laboratory, the dept of psychiatry in general, and the larger stem cell community at UT Southwestern to move from correlative to causative studies. Novel mouse model, unpublished and recently published data, movies of how we model these disorders in laboratory animals. Fike, Limoli, and Raber Why does

Unravelling Autism • Preston Wiles M.D. • Professor, UTSWMC • Senior Attending, Autism Center Learning Objectives • Describe essential features of autism spectrum disorders • Overview of genetic factors in the disorder • Understand brain function related to core features of autism • Review features of epidemiology-is there an epidemic or not • Role of science/education vs. Myth/meme Autism Spectrum Disorders • Autistic Disorder • Pervasive Developmental