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STARS Mini-Symposium Skeletal Muscle: Development, Adaptation & Disease “Gain Without Pain” Rhonda Bassel-Duby, Ph.D. Associate Professor of Molecular Biology Diagram of Skeletal Muscle Myoglobin Immunohistochemistry Subtypes of Skeletal Myofibers Type I (slow)Type I (slow) Type Type IIaIIa Type Type IIb IIb (fast)(fast) white, glycolytic fatigue rapidly rapid force development insulin-resistant red, oxidative fatigue-resistant slow contraction insulin-sensitive endurance

Medical Student Research for Project Description Form All descriptions must contain enough detail to permit an assessment of the problem that is to be addressed and the methodologies that are to be employed. Please be careful to outline the role that the student will play in the project that is described. Please ensure that all relevant approval numbers (IRB, IACUC) are provided. Mentor: Department: Room number: Phone number: E-mail: Research Coordinator: Project title: Human

Transcriptional Control of Neural Diversity Jane E. Johnson, PhD UT Southwestern Medical Center Department of Neuroscience � � Ey les� � � � � � i � Evd� � � Alb� Nervous  System   •  Brain   •  Spinal  cord   •  Sensory  systems   •  Neurons   •  Oligodendrocytes   •  Astrocytes   Modified from J. Hsieh Tuj1! RIP! GFAP

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A. Axial T2-weighted MRI scan through the lateral ventricles of the brain reveals abnormal high signal intensity within the corticospinal tracts (arrows). B. Axial T2- weighted image through the level of the internal capsules reveals abnormal foci of high singal intensity in the posterior limbs of the internal capsule (arrows). This MRI feature represents an increase in water content in myelin tracts undergoing Wallerian degeneration secondary to cortical neuronal loss. This finding is commonly

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Stroke:Stroke: Incidence and Cost in the United StatesIncidence and Cost in the United States ◆ 700,000 new cases yearly ◆ #3 cause of death ◆ $43 billion annual health cost (1998) ◆ 4,400,000 stroke survivors at high risk for recurrence Most strokes can be prevented Cost of StrokeCost of Stroke ◆ Stroke severity includes a broad range; about half of survivors unable to walk unaided. ◆ Acute inpatient costs average $38,000 but are only a fraction of total economic burden (including

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