Osmosis and Osmoregulation Robert Alpern, M.D. Southwestern Medical School Water Transport Across Semipermeable Membranes • In a dilute solution, Jv = Lp (∆P - RΤ∆CS ) • Jv - volume or water flux • Lp - hydraulic conductivity or permeability • ∆P - hydrostatic pressure gradient • R - gas constant • T - absolute temperature (Kelvin) • ∆Cs - solute concentration gradient Osmotic Pressure • If Jv = 0, then ∆P = RT∆Cs van’t Hoff equation ∆Π

10/10/2013 1 "From Molecules to Man: The Importance of Molecular Imaging in Clinical Medicine” A. Dean Sherry, Ph.D. Director, Advanced Imaging Research Center, UT Southwestern Medical Center Professor of Radiology, UT Southwestern Professor of Chemistry, UT Dallas ADVANCED IMAGING RESEARCH CENTER A IR C Frontiers in Biomedical Imaging symposium for STARS, Oct. 12, 2013 What is Molecular Imaging? bioluminescence "Anatomy Lesson of Dr. Nicolaes Tulp" by Rembrandt (slightly

Molecular Mechanisms of Circadian Clocks Circadian Rhythms • Endogenous rhythm which persists under constant conditions • Period of approximately 24 hours • Entrainable (reset) by environmental cues such as light and temperature • Temperature compensated - period stays about the same at different temperatures Circadian rhythm of locomoter activity Body temperature cycle Circadian rhythm of melatonin secretion Circadian rhythms of photosynthetic genes in plants

Cardiovascular Alterations Team Basic Science Clinical Science Mature Countermeasure Space Radiation Human Health and Countermeasures Cardiovascular Alterations Team Radiation, Endothelial Cell Senescence, Accelerated Aging, and Atherosclerosis PI. Art Shoukas, Ph.D. Johns Hopkins University Effect of high energy particle irradiation on adhesiveness of vascular endothelium and its consequences for atherosclerosis PI: Dennis Kucik, M.D. The University of Alabama at

Microarrays Ralph V. Shohet, M.D. Department of Internal Medicine, UTSWMC Outline 1. Types of microarrays 2. How to make one 3. How to use one Historical perspective 1. Watson-Crick basepairing 2. Southern & Northern analysis 3. Genome project Types of microarrays 1. Synthesized in situ 2. Spotted Types of microarrays 1. Synthesized in situ Short oliogonucleotides (25mers) masked and DOC particularly useful for interrogating small regions of a gene for sequence

Obesity A Review for Teachers Outline • The prevalence of obesity & associated medical problems has increased greatly in the US, both among adults & children. • The causes are complex. • Controlling obesity by exercise & diet is difficult. • Drug therapy is not very effective. Surgery may be necessary for severe obesity. How Do We Define Overweight & Obesity? • In adults, obesity is defined by the BMI (Body Mass Index), which is the weight in kilograms divided by height in

1 www4.utsouthwestern.edu/FrederickGrinnell/hsinteract.htm Teaching Bioethics to High School Students Ethics,morals,law Ethics Greek: ethos, character Morals Latin: moralis, custom Law Old English: lagu, laid down 2 Some Theories Focus on the Elements of Human Behavior Actor  Action  Outcome Actor - Character Action - Obligations Outcome - Consequences Universal Approaches to Ethical-Decision Making Situation evaluated according to general theories, principles, or

STARS A Valuable Resource for Health Science Teachers 2006 Health Science Technology Education Professional Development Conference July 19, 2006 Joel M. Goodman, Ph.D. Professor of Pharmacology STARS Director Today’s agenda Introduction to STARS Suture clinic What is STARS? • Science Teacher Access to Resources at Southwestern • Developed at UT Southwestern in 1991 to improve science teaching in north Texas. • Currently offer 17 programs and activities for secondary school