Cases in employees 0 10 20 30 40 50 60 70 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 Day of onset (July) Cases 0 10 20 30 40 50 60 70 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 Employees Visitors Cases Day of onset (July) Cases in employees and visitors Secondary attack rate Cases in household members Total number of household members X 100 • Epidemiology: the study of diseases in populations • Epidemic: an unusual occurrence (a significant increase in

TYPE 2 DIABETES MELLITUS:TYPE 2 DIABETES MELLITUS: NEW HOPE FOR PREVENTIONNEW HOPE FOR PREVENTION Robert Dobbins, M.D. Ph.D.Robert Dobbins, M.D. Ph.D. Learning ObjectivesLearning Objectives Recognize current trends in the Recognize current trends in the prevalence of type 2 diabetes.prevalence of type 2 diabetes. Learn differences between type 1 Learn differences between type 1 and type 2 diabetes.and type 2 diabetes. List risk factors for type 2 diabetes.List risk factors for type 2

WEIGHT REGULATION AND THE ROLE OF LEPTIN J. Denis McGarry, Ph.D. A portion of this outline has been taken, with permission, from a Medical Grand Rounds lecture on the genetics of obesity given by Rody Cox, M.D. at U.T. Southwestern, March 7, 1996. Obesity has become a world-wide epidemic, particularly in developed countries. It is associated with a number of serious morbidities, including Type 2 diabetes, osteoarthritis and hypertension. The current cost of obesity/Type 2 diabetes syndromes

Unravelling Autism • Preston Wiles M.D. • Professor, UTSWMC • Senior Attending, Autism Center Learning Objectives • Describe essential features of autism spectrum disorders • Overview of genetic factors in the disorder • Understand brain function related to core features of autism • Review features of epidemiology-is there an epidemic or not • Role of science/education vs. Myth/meme Autism Spectrum Disorders • Autistic Disorder • Pervasive Developmental

Infertility Update George R Attia, M.D Director of IVF Program University of Texas Southwestern Medical Center at Dallas Infertility • Inability to conceive after one year of adequate unprotected intercourse (six months if the woman is over age 35) Time Required for Conception in Couples Who Will Attain Pregnancy 25 45 57 72 85 93 95 0 10 20 30 40 50 60 70 80 90 100 1 month 2 months 3 months 6 months 1 Year 2 Year 3 ear % P re gn an t 35% 35% 20% 7% 3% Male

Dissecting the Role of MeCP2 in Brain & Implications for Autism Spectrum Disorders Lisa M. Monteggia, Ph.D. Department of Psychiatry UT Southwestern Medical Center, Dallas, TX Autism • Twin studies examining the concordance of autism spectrum disorders for identical twins, compared to fraternal twins or siblings, indicates a strong genetic component. • Many genes have been associated with autism, but each has been found in only a few individuals. • No single

• Scan in photos of orcas feeding on great whales • Know there are lots of orcas in the north Pacific A Life without Oxygen: The Physiology of Marine Mammals <Picture> COMPETITION FOR RESOURCES How marine mammals do what they do! Dive Response • Stop Breathing • ↓ Cardiac Output • ↓ Peripheral Blood Flow • Lungs Collapse below 60m • But Maintain Aerobic Metabolism Adaptations to Maintain Aerobic Metabolism under Hypoxic