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Antibiotics Joel Goodman STARS Minisymposium March 6, 2006 Outline • The spectrum of infectious agents and the global problem of human infections • Classification of bacteria • Intro to antibiotic classes, drug targets and resistance • Three antibiotics in detail – Sulfonamides – Penicillin – Streptomycin Statement by Dr. David L. Heymann Executive Director for Communicable Diseases World Health Organization Before the Committee on International Relations U.S. House of

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Cost Transfer Justification Form for Sponsored Projects INSTRUCTIONS: Please complete and attach this form to each transfer request that will move costs on or off grant Chart of Accounts to or from other grant or non-grant Chart of Accounts. Complete all COA fields and questions 1-4 if applicable and provide the detail supporting documentation. Additional information can be found on the Cost Transfer Guidance document. Date Error was discovered by Department: Click or tap to enter a date

© 2008 UT Southwestern Medical Center at Dallas Concise Health Risk Tracking (CHRT) with Clinician Rated Behavioral Module Please rate the extent to which each of the following statements describes how you have been feeling or acting in the past week. For example, if you feel the statement very accurately describes how you have been feeling in the past week, you would give a rating of “Strongly Agree.” If you feel the statement is not at all how you have been feeling in the past week

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Anti-malarial Drug Discovery Jeffrey Baldwin, PhD UT Southwestern Medical Center Department of Pharmacology Malaria Burden Life Cycle Jones & Good, Nature Medicine (Feb. 2006) Complex life cycle Intracellular parasite Pathogenesis 4 Plasmodium species are human pathogens: Falciparum Vivax Ovale Malariae Miller et al, Nature (7 Feb, 2002) Clinical Outcomes Miller et al, Nature (7 Feb, 2002) Immune Evasion PfEMP1 is key to lethality of P. falciparum Sticky molecules evade

AGING, MEMORY, AND AGING, MEMORY, AND THE BRAINTHE BRAIN Anne M. Lipton, M.D., Anne M. Lipton, M.D., PhPh.D..D. Assistant Professor of Neurology Assistant Professor of Neurology and Psychiatryand Psychiatry UTUT--SouthwesternSouthwestern NORMAL AGING AND THE BRAINNORMAL AGING AND THE BRAIN •• Reduced brain weight and volumeReduced brain weight and volume •• Fewer neuronsFewer neurons •• Widening ofWidening of sulcisulci (grooves)(grooves) •• Enlargement of the ventricular Enlargement of