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1 Cancer Cancer NanomedicineNanomedicine JinmingJinming GaoGao, Ph.D., Ph.D. Department of PharmacologyDepartment of Pharmacology Harold C. Simmons Comprehensive Cancer CenterHarold C. Simmons Comprehensive Cancer Center UT Southwestern Medical CenterUT Southwestern Medical Center Departments of Chemistry and BioengineeringDepartments of Chemistry and Bioengineering UT DallasUT Dallas 12,75612,756 kmkm NanomedicineNanomedicine in in PerspectivePerspective Mother EarthMother Earth 25.4

Cases in employees 0 10 20 30 40 50 60 70 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 Day of onset (July) Cases 0 10 20 30 40 50 60 70 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 Employees Visitors Cases Day of onset (July) Cases in employees and visitors Secondary attack rate Cases in household members Total number of household members X 100 • Epidemiology: the study of diseases in populations • Epidemic: an unusual occurrence (a significant increase in

? "@ Understanding Cellular Systems Using Genome Data Kim Reynolds, UT Southwestern, Sept. 2014 Why is this problem hard?! ! Detailed knowledge of the molecular players…! an apparently dense, interconnected network.! Why is this problem hard?! ! Detailed knowledge of the molecular players…! an apparently dense, interconnected network.! ! A complex biological system. what do we mean by complex? Hillenmeyer, ME et al. (2008) Science 320, p 5874 gene essentiality in yeast for ~5000

ß-Lapachone, a ‘Kiss of death’ therapy for cancer David A. Boothman, Ph.D. Laboratory of Molecular Stress Responses Program in Cell Stress and Cancer Nanomedicine Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center at Dallas September 14, 2008 Cellular Damage New Gene Expression Exploitable Target: Expressed in Human Tumors, not (or low) in Normal Tissues Bioactivate Drug For Tumor-Selective Killing -Not cell cycle

How is the brain influenced by radiation? Amelia J. Eisch, Ph.D. Department of Psychiatry, UT Southwestern October 3, 2009 Presenter Presentation Notes Here I will review the efforts of my laboratory, the dept of psychiatry in general, and the larger stem cell community at UT Southwestern to move from correlative to causative studies. Novel mouse model, unpublished and recently published data, movies of how we model these disorders in laboratory animals. Fike, Limoli, and Raber Why does

How Neurons Communicate at Synapses Jose Rizo-Rey White gives check mate in two moves Samuel Loyd 1859 So beautiful! Samuel Loyd 1859 OUR AMAZING BRAIN http://research.vtc.vt.edu/news/2013/feb/13/brain-awareness-week-designed-highlight-advances-b/ trauma.blog.yorku.ca arttattler.com Neurons are the key cells that make the brain so unique (drawings by Santiago Ramon y Cajal) https://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved

9/12/16   1   STARS Mini-Symposium 9/12/2016 DNA Sequencing: The Past, the Present and the Future Ralf Kittler, Ph.D. McDermott Center for Human Growth and Development ralf.kittler@utsouthwestern.edu Outline DNA sequencing is a biochemical method to determine the sequence of the nucleotide bases that make up the DNA 1.   The Past – Sanger Sequencing 2.   The Present – Illumina Sequencing 3. The Future – Single Molecule Sequencing 9/12/16   2   Part 1 The past

Infertility Update George R Attia, M.D Director of IVF Program University of Texas Southwestern Medical Center at Dallas Infertility • Inability to conceive after one year of adequate unprotected intercourse (six months if the woman is over age 35) Time Required for Conception in Couples Who Will Attain Pregnancy 25 45 57 72 85 93 95 0 10 20 30 40 50 60 70 80 90 100 1 month 2 months 3 months 6 months 1 Year 2 Year 3 ear % P re gn an t 35% 35% 20% 7% 3% Male