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Researchers have discovered that a molecule – estrogen-related receptor gamma, or ESRRG – becomes hyperactive and promotes tumor cell survival in retinoblastoma.

New research from UT Southwestern suggests that RNA exosomes– the cellular machines that degrade old molecules of RNA – play a key role in the development of B cells, which are critical to the immune system’s ability to protect against infection.

Individuals should weigh their own personal health and risk levels in deciding when to receive a second booster of the COVID-19 vaccine, UT Southwestern infectious diseases experts advise.

Changes in habits during the pandemic can lead to unexpected health issues with feet and ankles. Orthopedic surgeon Kshitij Manchanda, M.D. at UT Southwestern Orthopaedic Surgery and Sports Medicine has seen an increase in both reported injuries and chronic problems.

UT Southwestern researchers Zhijian “James” Chen, Ph.D., and Sihan Wu, Ph.D., are part of a team that has been awarded a Cancer Grand Challenges grant, a unique award that aims to solve some of cancer’s toughest problems by bringing together global teams with diverse areas of expertise.

Patients with rheumatoid arthritis, lupus, and other rheumatic conditions are more at risk for complications and death from pneumonia, meningitis, and other bacterial infections, yet most have not been vaccinated against infection.

The Pfizer-BioNTech COVID-19 vaccine limits transmission, hospitalization, and death from COVID-19 even among patients infected by variants of the virus, but the effectiveness of antibodies it generates diminishes as patients get older, according to a study by UT Southwestern researchers.

A normal process called cell competition, in which healthy tissues eliminate unhealthy cells, could be responsible for cancer relapses in patients months or years after they were declared cancer-free, a new study by UT Southwestern researchers suggests.

The number of surgeries performed on Black, Latino, and Asian children is significantly lower than among white children in the United States, a UT Southwestern study has found. These differences may reflect inequities in access to surgical care.

Changes in weather that accompany the return to school each fall can create a challenging environment for children who suffer from asthma, the most common pediatric chronic illness.