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A team led by UT Southwestern Medical Center researchers has discovered a new way that cells regulate senescence, an irreversible end to cell division. The findings, published in Cell, could one day lead to new interventions for a variety of conditions associated with aging, including

Multidrug resistance in cancer can be overcome by combining a drug that blocks a key enzyme with another anticancer drug, according to a study in preclinical models led by researchers at UT Southwestern Medical Center. The findings, published in Science Advances, could have implications for patients

UT Southwestern researchers have discovered a mechanism that cells use to degrade microRNAs (miRNAs), genetic molecules that regulate the amounts of proteins in cells.

A far shorter, simpler, and less toxic treatment protocol for patients with triple-negative breast cancer produced outcomes similar to the current standard of care, a clinical trial co-led by a UT Southwestern Medical Center researcher shows.

A team led by UT Southwestern Medical Center researchers has identified a key mechanism responsible for endosomal recycling in cells, a process critical to human health. Their findings, published in Nature Communications, answer a fundamental question in cell biology and could lead to therapies for

Early in his career, Ralf Kittler, Ph.D., attracted the attention of academic leaders at UT Southwestern Medical Center with his studies of DNA transcription factors and their role in tumor growth and suppression.

In an animal model of multiple sclerosis (MS), decreasing the amount of a protein made in the liver significantly protected against development of the disease’s characteristic symptoms and promoted recovery in symptomatic animals, UTSW scientists report.

Tripling the standard dose of semaglutide, a popular drug prescribed to treat obesity, led to significantly greater weight loss and associated metabolic benefits without increased risk of serious side effects, a multicenter clinical trial led by a UT Southwestern Medical Center researcher shows.

UT Southwestern Medical Center researchers have identified a gene called Lipe that appears to be pivotal to retinal health, with mutations spurring immune activation and retinal degeneration. This is important because the retina is responsible for detecting the light that is transformed into vision.

Studies look at measuring blood flow velocity, a treatment strategy for non-small cell lung cancer, and the body’s response to airborne pathogens.