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A two-step screening protocol that combines clinical risk assessment with biomarker testing can more effectively identify which patients with Type 2 diabetes need medication to prevent heart failure, according to a study led by UT Southwestern Medical Center researchers.

An experimental form of insulin administered just once a week was safe for patients with Type 2 diabetes and helped them maintain healthy blood sugar levels better than insulin injected daily, according to the results of a phase 3 clinical trial led by a UT Southwestern Medical Center researcher.

Triptans, a commonly prescribed class of migraine drugs, may also be useful in treating obesity, a new study by scientists at UT Southwestern suggests.

UT Southwestern will lead a multisite initiative funded by the National Cancer Institute (NCI) to identify biomarkers to improve risk assessment and early detection of hepatocellular cancer (HCC), the most common form of liver cancer, among patients with cirrhosis.

Liver cells have a vital metabolic inflexibility during regeneration to starve dysfunctional cells and keep damage from spreading, according to new research from Children’s Medical Center Research Institute at UT Southwestern (CRI) published in Science.

A new type of CAR T-cell therapy more than triples the expected length of remission for multiple myeloma patients who have relapsed several times, according to an international clinical trial with UT Southwestern as the lead enrolling site.

Immunotherapy drugs that target a protein called programmed death ligand 1 (PD-L1) on the surface of cancer cells have quickly become a mainstay to treat many forms of cancer, often with dramatic results.

About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now, UT Southwestern scientists have discovered a new role for p53 in its fight against tumors: preventing retrotransposons, or “jumping genes,” from hopping around the human genome.

UT Southwestern researchers have determined how circulating “bad cholesterol” enters artery walls to cause the plaque that narrows the blood vessels and leads to heart attacks and strokes.

Wheelchair users are nearly three times more likely to experience hospital readmission following total shoulder arthroplasty (TSA), according to UT Southwestern Medical Center researchers.