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UT Southwestern biochemist Zhijian “James” Chen, Ph.D., famously identified the cGAS enzyme pathway that alerts the human immune system to disease-causing invaders like viruses. Since then, researchers have found that cGAS signaling is an ancient, conserved defense strategy stretching from bacteria

UT Southwestern researchers have discovered a new form of progeria, a rare premature-aging syndrome, in a man from Malaysia and traced its cause to a novel gene mutation.

Using the CRISPR-Cas9 gene editing system, UT Southwestern researchers corrected mutations responsible for a common inherited heart condition called dilated cardiomyopathy (DCM) in human cells and a mouse model of the disease.

When McKinney real estate developer John Hill was 35, his father died of prostate cancer. The elder Mr. Hill had undergone surgery to remove his prostate a few years earlier, but the cancer had already spread.

Summertime means lots of opportunities for fun in the sun. But this year’s high temperatures also bring an increased risk of dehydration that can cause urinary tract infections (UTIs), said Maude Carmel, M.D., Associate Professor of Urology at UT Southwestern Medical Center.

A single protein can reverse the developmental clock on adult brain cells called astrocytes, morphing them into stem-like cells that produce neurons and other cell types, UT Southwestern researchers report in a PNAS study.

A new study by the Kidney Cancer Program (KCP) at UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center shows that highly focused radiation to isolated metastases that progress despite drug therapy can prolong drug use in kidney cancer patients, saving the few other drugs for treating

A pregnant mother who tested positive for COVID-19 transmitted the virus causing the disease to her prematurely born baby, UT Southwestern physicians report. Both were treated and recovered.

As you drift into unconsciousness before a surgery, general anesthetic drugs flowing through your blood are putting you to sleep by binding mainly to a protein in the brain called the ɣ-aminobutyric acid type A (GABAA) receptor.

Research led by UT Southwestern scientists suggests that an investigational drug could restore the ability of some non-small cell lung cancers (NSCLCs) to respond to an immune checkpoint blockade (ICB), a therapy that harnesses the immune system to fight malignant tumors.