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A molecule has demonstrated its ability to kill tumor cells and incite an immune response in preclinical models of small cell lung cancer (SCLC), according to UT Southwestern Medical Center researchers.

A nanoparticle-based therapy developed by UT Southwestern Medical Center scientists stimulated an immune pathway that eradicated tumors in mouse models of various cancer types.

When cancer cells metastasize, breaking away from the primary tumor and spreading to blood, tissue, or lymph nodes, the disease is at its most lethal.

Obese mice whose fat cells were genetically altered to produce an increased amount of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lost more than a third of their body weight through a mechanism that burns energy, UT Southwestern Medical Center researchers report in a new study.

In just a few hours, UT Southwestern scientists can tell which variant has infected a COVID-19 patient – a critical task that can potentially influence treatment decisions but takes days or weeks at most medical centers.

Patients with cutaneous lupus erythematosus (CLE), an autoimmune disease that causes skin inflammation, have a higher risk for atherosclerotic cardiovascular disease (ASCVD), or hardening of the arteries, UT Southwestern Medical Center researchers found.

Over the first year of the COVID-19 pandemic, almost 30% of patients with obesity gained more than 5% of their body weight, and 1 in 7 gained more than 10%. While diet and exercise habits were factors, people with the highest levels of stress, anxiety, and depression reported the most weight gain.

Leveraging its broad expertise in biomedical informatics, data sciences, and clinical sciences, UT Southwestern Medical Center is aggressively expanding its involvement in clinical informatics, which aims to harness the power of big data to improve patient care and public health.

Artificial intelligence is rapidly reshaping the landscape of health care, revolutionizing scientific discovery, drug development, diagnosis and treatment, as well as health care delivery operations. As with any emerging technology, its success lies in its implementation, and The University of Texas

– Sex-specific differences in the knee joint should be considered as early as childhood to help prevent higher incidence and severity of knee osteoarthritis (OA) in women later in life, UT Southwestern Medical Center researchers propose in a review of clinical data.