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Mutations in a gene called OTP cause obesity by controlling the output of another gene already targeted by an anti-obesity drug, a study led by UT Southwestern Medical Center researchers shows.

An investigational therapy significantly shrank lung cancer tumors that are notoriously resistant to treatment by encouraging an attack from natural killer (NK) cells in an animal model, a study led by UT Southwestern Medical Center researchers shows.

Researchers at UT Southwestern Medical Center have linked blindness in animal models to a brain-wide cellular stress response that’s a common risk factor for dementia. Their findings, published in Nature Communications, could help explain the connection between vision or hearing loss and dementia.

– A “clot-busting” drug recently approved to treat acute ischemic strokes (AIS) that can be delivered quickly works as well as a decades-old medication used by most hospitals in the U.S. and could hold significant advantages for some patients, a study led by a UT Southwestern Medical Center

Weight-loss surgeries for adolescents increased 15% in the U.S. between 2021 and 2023, even as the Food and Drug Administration (FDA) approved effective new weight-loss medications for this age group, a study led by UT Southwestern Medical Center researchers shows. Their findings, published in The

Using a tool called Automated Meiotic Mapping (AMM) that was developed at UT Southwestern Medical Center, a team of researchers has identified a gene that appears to be key for regulating food intake.

A traditional Chinese medicine whose name means “to open the network of the heart” reduced the risk of heart attacks, deaths, and other major cardiovascular complications for at least a year after a first heart attack, a study led by UT Southwestern Medical Center researchers shows.

Pregnant individuals should be careful regarding energy drinks and their overall intake of caffeine, according to an expert at UT Southwestern Medical Center.

Researchers led by a team at UT Southwestern Medical Center have developed a device that can isolate blood flow to the brain, keeping the organ alive and functioning independent from the rest of the body for several hours.

Saad B. Omer, M.B.B.S., M.P.H., Ph.D., Founding Dean of the Peter O’Donnell Jr. School of Public Health at UT Southwestern Medical Center, discovered a passion for public health while he was a medical student in Pakistan.