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A UT Southwestern research team has catalogued gene activity in the skeletal muscle of mice, comparing healthy animals to those carrying a genetic mutation that causes Duchene muscular dystrophy (DMD) in humans.

New research has uncovered a surprising role for so-called “jumping” genes that have traditionally been considered a source of genetic mutations responsible for a number of human diseases.

UT Southwestern researchers have identified factors that put patients with childhood-onset lupus at elevated risk for poor outcomes, such as end-stage renal disease or death, as they transition from pediatric to adult health care.

UT Southwestern faculty have discovered what appears to be an Achilles’ heel in ovarian cancers, as well as new biomarkers that could point to which patients are the best candidates for possible new treatments.

Newly developed artificial intelligence (AI) programs accurately predicted the role of DNA’s regulatory elements and three-dimensional (3D) structure based solely on its raw sequence, according to two recent studies in Nature Genetics.

The dominant form of heart failure worldwide appears to be caused by a strong, bidirectional interaction between the body’s response to metabolic stress and the immune system, according to a review article written by UT Southwestern researchers and colleagues.

UT Southwestern is joining with medical centers around the nation to apply advanced sequencing to pediatric brain tumors as part of the National Cancer Institute’s new Molecular Characterization Initiative, a subset of the Cancer Moonshot Childhood Cancer Initiative.

UT Southwestern Medical Center scientists have identified the first two cases of the B.1.617.2 (Indian origin) variant of COVID-19 infection in North Texas using next-generation sequencing technologies along with targeted PCR testing.

More teenage athletes experienced depression and anxiety during the early weeks of the pandemic, when COVID-19 restrictions curtailed sports activities, according to a survey of 600 child and adolescent athletes led by researchers at UT Southwestern and Scottish Rite for Children.

A set of biomarkers not traditionally associated with cell fate can accurately predict how genetically identical cells behave differently under stress, according to a UT Southwestern study.