Featured Publications

Discovery of a selective inhibitor of doublecortin like kinase 1.

Ferguson FM, Nabet B, Raghavan S, Liu Y, Leggett AL, Kuljanin M, Kalekar RL, Yang A, He S, Wang J, Ng RWS, Sulahian R, Li L, Poulin EJ, Huang L, Koren J, Dieguez-Martinez N, Espinosa S, Zeng Z, Corona CR, Vasta JD, Ohi R, Sim T, Kim ND, Harshbarger W, Lizcano JM, Robers MB, Muthaswamy S, Lin CY, Look AT, Haigis KM, Mancias JD, Wolpin BM, Aguirre AJ, Hahn WC, Westover KD, Gray NS, Nat. Chem. Biol. 2020 Apr

GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRAS^P34R.

Bera AK, Lu J, Lu C, Li L, Gondi S, Yan W, Nelson A, Zhang G, Westover KD, Birth Defects Res 2020 Mar

Dynamic surveillance of tamoxifen-resistance in ER-positive breast cancer by CAIX-targeted ultrasound imaging.

Li Y, Chen X, Zhou Z, Li Q, Westover KD, Wang M, Liu J, Zhang S, Zhang J, Xu B, Wei X, Cancer Med 2020 Feb

Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine.

Du G, Rao S, Gurbani D, Henning NJ, Jiang J, Che J, Yang A, Ficarro SB, Marto JA, Aguirre AJ, Sorger PK, Westover KD, Zhang T, Gray NS, J. Med. Chem. 2020 Jan

Structure and Characterization of a Covalent Inhibitor of Src Kinase.

Gurbani D, Du G, Henning NJ, Rao S, Bera AK, Zhang T, Gray NS, Westover KD, Front Mol Biosci 2020 7 81

A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase.

Scarneo SA, Hughes PF, Yang KW, Carlson DA, Gurbani D, Westover KD, Haystead TAJ, J. Biol. Chem. 2019 Dec

Publisher Correction: Green Synthesis of Substituted Anilines and Quinazolines from Isatoic Anhydride-8-amide.

Gondi SR, Bera AK, Westover KD, Sci Rep 2019 Dec 9 1 20379

Exploring Targeted Degradation Strategy for Oncogenic KRAS^G12C.

Zeng M, Xiong Y, Safaee N, Nowak RP, Donovan KA, Yuan CJ, Nabet B, Gero TW, Feru F, Li L, Gondi S, Ombelets LJ, Quan C, Jänne PA, Kostic M, Scott DA, Westover KD, Fischer ES, Gray NS, Cell Chem Biol 2019 Dec

Green Synthesis of Substituted Anilines and Quinazolines from Isatoic Anhydride-8-amide.

Gondi SR, Bera AK, Westover KD, Sci Rep 2019 Oct 9 1 14258

Structural basis of the atypical activation mechanism of KRAS V14I.

Bera AK, Lu J, Wales TE, Gondi S, Gurbani D, Nelson A, Engen JR, Westover KD, J. Biol. Chem. 2019 Jul