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|Graduate Students||Postdoctoral Fellows||Researchers/Staff||Principal Investigator|
Lianbo Li, Ph.D. – Biophysics/Biochemistry
Education: B.S. – Biotechnology, 2007, Shandong Normal University, China; Ph.D. – Cell Biology, 2014, Peking University, China
Research interests: Protein structure-guided drug discovery with emphasis on the oncogenic protein KRAS.
Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C. Cell Chem Biol. 2017.
Covalent Guanosine Mimetic Inhibitors of G12C KRAS. ACS medicinal chemistry letters 8, 61-66. 2017.
Rationale for RAS mutation-tailored therapies. Future Oncol 13, 263-271. 2017.
Structural Insights on the bacteriolytic and self-protection mechanism of muramidase effector Tse3 in Pseudomonas aeruginosa. J Biol Chem 288, 30607-30613. 2013.
Zhi-Wei (George) Zhou, Ph.D. – Cancer Biology/Biophysics
Education: B.S. – Biotechnology and Pharmacology, 2007, Nanchang University, China; Ph.D. – Health Sciences, 2013, RMIT University, Melbourne, Australia
Research interests: Cancer pharmacology and anticancer drug (synthesized and natural compounds) discovery and development, with a specific focus on KRAS.
Inhibition of Aurora kinases induces apoptosis and autophagy via AURKB/p70S6K/RPL15 axis in human leukemia cells. Cancer Letters 2016 Sep 6;382(2):215-230.
Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells. Cancer Lett 2014 Mar 28;344(2):239-259. 24280585.
MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through down-regulation of the nuclear receptor co-repressor dosage-sensitive sex reversal adrenal hypoplasia congenital critical region on X chromosome, gene 1 (DAX-1). Drug Metab Dispos 2014 Jan;42(1):44-61. 24104199.
Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.hy926. Eur J Pharmacol 2012 Dec 15;697(1-3):97-105.
Xingxiao (Shelly) Li, M.S. – Cancer Biology
Education: B.S. – Biotechnology, 2007, Nanchung University, China; M.S. – Cancer Biology, 2010, Guangdong Cardiovascular Institute, China
Research interests: Development of cellular and biological techniques including, but not limited to, culturing noncancerous and cancerous cell lines and molecular biology.
Cynthia Meyer, B.S. – Biological Sciences
Education: B.S. – Biological Sciences, 1987, Stanford University, Palo Alto, CA
Research interests: Exploration of how molecular biology is used in anticancer drug research.