Lab Members

Lab Members

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Graduate Students Postdoctoral Fellows Researchers/Staff Principal Investigator

Graduate Students

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Postdoctoral Fellows

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Faculty/Staff

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Lianbo Li, Ph.D. – Biophysics/Biochemistry

Lianbo

Education: B.S. – Biotechnology, 2007, Shandong Normal University, China; Ph.D. – Cell Biology, 2014, Peking University, China

Research interests: Protein structure-guided drug discovery with emphasis on the oncogenic protein KRAS.

Selected publications:

Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C. Cell Chem Biol. 2017.

KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry. Structure. 2017.

Covalent Guanosine Mimetic Inhibitors of G12C KRAS. ACS medicinal chemistry letters 8, 61-66. 2017.

Rationale for RAS mutation-tailored therapies. Future Oncol 13, 263-271. 2017.

Structural Insights on the bacteriolytic and self-protection mechanism of muramidase effector Tse3 in Pseudomonas aeruginosa. J Biol Chem 288, 30607-30613. 2013.

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Zhi-Wei (George) Zhou, Ph.D. – Cancer Biology/Biophysics

george

Education: B.S.  Biotechnology and Pharmacology, 2007, Nanchang University, China; Ph.D.  Health Sciences, 2013, RMIT University, Melbourne, Australia

Research interests: Cancer pharmacology and anticancer drug (synthesized and natural compounds) discovery and development, with a specific focus on KRAS.

Selected publications:

Inhibition of Aurora kinases induces apoptosis and autophagy via AURKB/p70S6K/RPL15 axis in human leukemia cells. Cancer Letters 2016 Sep 6;382(2):215-230.

Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells. Cancer Lett 2014 Mar 28;344(2):239-259. 24280585.

MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through down-regulation of the nuclear receptor co-repressor dosage-sensitive sex reversal adrenal hypoplasia congenital critical region on X chromosome, gene 1 (DAX-1). Drug Metab Dispos 2014 Jan;42(1):44-61. 24104199.

Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.hy926. Eur J Pharmacol 2012 Dec 15;697(1-3):97-105.

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Xingxiao (Shelly) Li, M.S. – Cancer Biology

Shelly

Education: B.S. – Biotechnology, 2007, Nanchung University, China; M.S. – Cancer Biology, 2010, Guangdong Cardiovascular Institute, China

Research interests: Development of cellular and biological techniques including, but not limited to, culturing noncancerous and cancerous cell lines and molecular biology.

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Cynthia Meyer, B.S. – Biological Sciences

Cynthia Meyer

Education: B.S.  Biological Sciences, 1987, Stanford University, Palo Alto, CA

Research interests: Exploration of how molecular biology is used in anticancer drug research.

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