Publications

Publications

    • Johnston AN, Wang Z. (2020). HSP70 promotes MLKL polymerization and necroptosis. Molecular & Cellular Oncology, DOI: 10.1080/23723556.2020.1791561.
    • Yu B, Ma J, Li J, Wang DZ, Wang Z, Wang S. (2020). Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics. Nat Commun 11 (1), 2549.
    • Johnston AN, Ma Y, Liu H, Liu S, Hanna-Addams S, Chen S, Chen C, Wang Z. (2020b). Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis. Proc Natl Acad Sci U S A 117(12):6521-6530.
    • Hanna-Addams S, Liu S, Liu H, Chen S, Wang Z. (2020a). CK1α, CK1δ and CK1ε are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis. Proc Natl Acad Sci U S A 117 (4): 1962-1970.
    • Li Y, Zhang Z, Chen J, Liu W, Liu B, Li X, Liu L, Xu S, Dong Q, Wang Z, Wang H, Gao S, Zhu B. (2018). Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1. Nature 564, 136-140.
    • Johnston AN, Wang Z. (2018). Necroptosis: MLKL polymerization. J Nat Sci. 4 (7), e513.
    • Hanna-Addams, S and Wang, Z. (2018). Use of two-dimensional semi-denaturing detergent agarose gel electrophoresis to confirm size heterogeneity of amyloid or amyloid-like fibers, J Vis Exp (134), e57498, doi:10.3791/57498.

Mechanisms of necroptosis pathway research

    • Reynoso, E, Liu, H, Li, L, Yuan, A, Chen, S and Wang, Z (2017). Thioredoxin 1 actively maintains the pseudokinase MLKL in a reduced state to suppress MLKL polymerization and necroptosis. J Biol Chem 292, 17514-17524
    • Liu, S, Liu, H, Johnston, A, Hanna-Addams, S, Reynoso, E, Xiang, Y and Wang, Z. (2017). MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis. Proc Natl Acad Sci U S A , E7450-7459.
    • Hanus, J, Zhang, H, Wang, Z, Liu, Q Zhou, Q and Wang, S. (2013). Induction of necrotic cell death by oxidative stress in retinal pigment epithelial cells. Cell Death Dis 4: e965.
    • Wang, Z., Jiang, H., Chen, S., Du, F. and Wang, X. (2012). The mitochondrial phosphatase PGAM5 functions at the convergent point of multiple necrotic death pathways. Cell. 148(1-2):228-43. (Commented in 148(1-2):17-8. and evaluated in Faculty of 1000. F1000.com/13861956)
    • Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X. and Wang, X. (2012). Mixed Lineage kinase domain-like protein mediates necrosis signaling downstream of receptor-interacting serine-threonine kinase 3. Cell. 148(1-2):213-27. (Commented in Cell. 148(1-2):17-8., and evaluated in Faculty of 1000. F1000.com/14267354)
    • Wang, J., Li, A., Wang, Z., Feng, X., Olson, E.N., and Schwartz, R.J. (2007). Myocardin sumoylation transactivates cardiogenic genes in pluripotent 10T1/2 fibroblasts. Mol Cell Biol 27, 622-632.
    • Xing, W., Zhang, T.C., Cao, D., Wang, Z., Antos, C.L., Li, S., Wang, Y., Olson, E.N., and Wang, D.Z. (2006). Myocardin induces cardiomyocyte hypertrophy. Circ Res 98, 1089-1097.
    • Cao, D.*, Wang, Z.*, Zhang, C.L.*, Oh, J., Xing, W., Li, S., Richardson, J.A., Wang, D.Z., and Olson, E.N. (2005). Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol 25, 364-376. (* equal contribution).
    • Liu, Z.P., Wang, Z., Yanagisawa, H., and Olson, E.N. (2005). Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. Dev Cell 9, 261-270.
    • Oh, J.*, Wang, Z.*, Wang, D.Z.*, Lien, C.L., Xing, W., and Olson, E.N. (2004). Target gene-specific modulation of myocardin activity by GATA transcription factors. Mol Cell Biol 24, 8519-8528. (* equal contribution).­
    • Wang, Z., Wang, D.Z., Hockemeyer, D., McAnally, J., Nordheim, A., and Olson, E.N. (2004). Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature 428, 185-189.
    • Li, S., Wang, D.Z., Wang, Z., Richardson, J.A., and Olson, E.N. (2003). The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci U S A 100, 9366-9370.
    • Wang, Z., Wang, D.Z., Pipes, G.C., and Olson, E.N. (2003). Myocardin is a master regulator of smooth muscle gene expression. Proc Natl Acad Sci U S A 100, 7129-7134.
    • Wang, D.Z., Li, S., Hockemeyer, D., Sutherland, L., Wang, Z., Schratt, G., Richardson, J.A., Nordheim, A., and Olson, E.N. (2002). Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci U S A 99, 14855-14860.
    • Wang, D.Z., Chang, P.S., Wang, Z., Sutherland, L., Richardson, J.A., Small, E., Krieg, P.A., and Olson, E.N. (2001). Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell 105, 851-862.