Publications

Publications for Lorena Saelices, Ph.D.

  1. Cao Q, Anderson DH, Liang WY, Chou J, Saelices L* (2020) The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin. (unrefereed preprint, BioRxiv).
  2. Saelices L, Nguyen BA, Chung K, Wang Y, Ortega A, Lee JH, Coelho T, Bijzet J, Benson MD, Eisenberg DS (2019) A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils. The Journal of Biological Chemistry 294(15):6130-6141.
  3. Saelices L*, Pokrzywa M, Pawelek K, Eisenberg DS. (2018) Assessment of the effects of transthyretin peptide inhibitors in Drosophila models of neuropathic ATTR. Neurobiology of Disease 120:118-125.
  4. Saelices L, Chung K, Lee JH, Cohn W, Whitelegge JP, Benson MD, Eisenberg DS (2018) Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition. Proceedings of the National Academyof Sciences 115(29):E6741-E6750.
  5. Saelices L, Sievers SA, Sawaya MR, Eisenberg, DS (2018) Crystal structures of amyloidogenic segments of human transthyretin. Protein Science 27(7):1295-1303.
  6. Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS (2018) Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors. The Journal of Biological Chemistry 293(8):2888-2902.
  7. Pantoja-Uceda D, Neira JL, Saelices L, Robles-Rengel R, Florencio FJ, Muro-Pastor MI, Santoro J (2016) Dissecting the Binding between Glutamine Synthetase and Its Two Natively Unfolded Protein Inhibitors. Biochemistry, 55(24), 3370-3382.
  8. Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS (2015) Uncovering the Mechanism of Aggregation of Human Transthyretin. The Journal of Biological Chemistry 290: 28932-28943.
  9. Saelices L, Robles-Rengel R, Florencio FJ, Muro-Pastor MI (2015) A core of three amino acids at the carboxyl-terminal region of glutamine synthetase defines its regulation in cyanobacteria. Molecular Microbiology 96(3):483-96.
  10. Saelices L, Galmozzi CV, Florencio FJ, Muro-Pastor MI, Neira JL (2011) The inactivating factor of glutamine synthetase IF17 is an intrinsically disordered protein, which folds upon binding to its target. Biochemistry 50(45):9767-78.
  11. Saelices L, Galmozzi CV, Florencio FJ, Muro-Pastor MI (2011) Mutational analysis of the inactivating factors, IF7 and IF17 from Synechocystis sp. PCC 6803: critical role of arginine amino acid residues for glutamine synthetase inactivation. Molecular Microbiology 82(4):964-75.
  12. Galmozzi CV, Saelices L, Florencio FJ, Muro-Pastor MI (2010) Posttranscriptional regulation of glutamine synthetase in the filamentous Cyanobacterium Anabaena sp. PCC 7120: differential expression between vegetative cells and heterocysts. Journal of Bacteriology 192, 4701-11.
  13. Saelices L, Youssar L, Holdermann I, Al-Babili S, Avalos J (2007) Identification of the gene responsible for torulene cleavage in the Neurospora carotenoid pathway. Molecular Genetics and Genomics 278, 527-37.

Book Chapters

Saelices L, Galmozzi CV, Florencio FJ, Muro-Pastor MI (2011) Chapter of the book "Avances en el metabolismo del nitrógeno. Aproximación molecular al estudio del ciclo del nitrógeno en la biosfera y sus repercusiones agronómicas y medioambientales". Servicio de Publicaciones de la Univ. de Córdoba.

Structures Published on PBD

Full-length transthyretin variants: 6E71, 6E75, 6E76, 4TLU, 4TNF, 4TNG, 4TKW, 4TL4, 4TL5, 4TLK, 4TLS, 4TLT, 4TM9, 4TNE

Full-length transthyretin variants with stabilizing ligands: 6E6Z, 6E70, 6E72, 6E74, 6E73, 6E77, 6E78

Peptides in their amyloid state: 6C3F, 6C3G, 6C3S, 6C3T, 6C4O, 6C88, 5VOS, 4XFN, 4XFO

Glutamine synthetase: 3NG0