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Understanding mechanisms
of tumorigenesis

We investigate mechanisms of tumor initiation, progression, and metastasis using molecular and biochemical studies and animal models.

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Novel cancer therapeutics

We apply insights from molecular and genetic studies towards the development of new therapies for lung cancer and other tumor types.

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Functional genetic approaches

We perform unbiased genetic screens to uncover new therapeutic targets for cancer.

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Investigating new mechanisms of immune checkpoint regulation

Integrated stress response-dependent translation of PD-L1 in lung cancer, leading to suppression of anti-tumor immunity. Image depicts PD-L1 protein (left) engaging the T-cell PD-1 receptor (right).

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Meet the Lab