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ARH
We study the mechanisms by which the protein ARH supports LDLR-dependent LDL uptake, but is dispensable for LDLR-dependent VLDL uptake.
LDLR
Our research has shown how the LDLR responds to low pH and low calcium concentrations to release lipoprotein in endocytic vesicles.
Springs
By modifying amino acid residues of the helical protein ankyrin (ANK),we can alter its shape. We are now developing engineered ANK-repeat protein springs for making nanodevices.
Cavin-3
Cavin-3 is a tumor suppressor protein whose loss leads to cachexia (wasting), a frequent cause of death in cancer.