Autophagy and Neurodegeneration

Autophagy is a critical mechanism for the maintenance of neuronal function and the suppression of neurodegeneration. Our findings suggest a role for the Acinus protein in the regulation of this quality control function of autophagy. We aim to define the molecular mechanism of its regulatory function.

Electroretinograms Diagram
Electroretinograms show the requirement for Acinus expression to prevent age-dependent photoreceptor cell degeneration, which is further hastened by expression of Huntingtin-polyQ proteins.