We are a group of biophysicists, cell biologists and computational folks interested in the spatiotemporal organization of cell surface receptors, the mechanisms underlying it, and its consequences for cell signaling. We utilize light microscopy, particularly single-molecule and super-resolution imaging, to monitor molecular behavior in its native cellular environment, and we develop computer vision and mathematical modeling approaches to quantitate the observed behavior and gain insight beyond what the eye can see.
We hope that you enjoy the following 2-min Science Sketch video about the lab ...
... and our recent publications and preprints:
Da Rocha-Azevedo B., Lee S., Dasgupta A., Vega A. R., do Oliveira L. R., Kim T., Kittisopikul M., Malik Z. and Jaqaman K., 2020. Heterogeneity in VEGF Receptor-2 mobility and organization on the endothelial cell surface leads to diverse activation models by VEGF. Cell Reports, Accepted. Preprint on BioRXiv.
Kittisopikul M., Vahabikashi A., Shimi T., Goldman R. D. and Jaqaman K., 2020. Adaptive multi-orientation resolution analysis of complex filamentous network images. Bioinformatics, In Press.
De Oliveira L. R. and Jaqaman K., 2019. FISIK: Framework for the Inference of in Situ Interaction Kinetics from single-molecule imaging data. Biophysical Journal. 117: 1012-1028.