Publications

Publications

2020

Shah S, Molinaro G, Liu B, Wang R, Huber KM, Richter JD FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism.Cell Rep 2020 Mar 30 13 4459-4472.e6

McCamphill PK, Stoppel LJ, Senter RK, Lewis MC, Heynen AJ, Stoppel DC, Sridhar V, Collins KA, Shi X, Pan JQ, Madison J, Cottrell JR, Huber KM, Scolnick EM, Holson EB, Wagner FF, Bear MF, Selective inhibition of glycogen synthase kinase 3a corrects pathophysiology in a mouse model of fragile X syndrome. Sci Transl Med 2020 May 12 544

Hien A, Molinaro G, Liu B, Huber KM, Richter JD, Ribosome profiling in mouse hippocampus: plasticity-induced regulation and bidirectional control by TSC2 and FMRP. Mol Autism 2020 Oct 11 1 78

2019

Gonzalez D, Tomasek M, Hays S, et al. Audiogenic Seizures in the Fmr1 Knock-Out Mouse Are Induced by Fmr1 Deletion in Subcortical, VGlut2-Expressing Excitatory Neurons and Require Deletion in the Inferior Colliculus. J Neurosci. 2019;39(49):9852‐9863. doi:10.1523/JNEUROSCI.0886-19.2019

Goswami S, Cavalier S, Sridhar V, Huber KM, Gibson JR. Local cortical circuit correlates of altered EEG in the mouse model of Fragile X syndrome. Neurobiol Dis. 2019;124:563‐572. doi:10.1016/j.nbd.2019.01.002

2018

Huber KM. Synaptic homeostasis: quality vs. quantity. Nat Neurosci. 2018;21(6):774‐776. doi:10.1038/s41593-018-0159-4

Wilkerson JR, Albanesi JP, Huber KM. Roles for Arc in metabotropic glutamate receptor-dependent LTD and synapse elimination: Implications in health and disease. Semin Cell Dev Biol. 2018;77:51‐62. doi:10.1016/j.semcdb.2017.09.035

2017

Chang CW, Wilkerson JR, Hale CF, Gibson JR, Huber KM. Distinct stages of synapse elimination are induced by burst firing of CA1 neurons and differentially require MEF2A/D. Elife. 2017;6:e26278. Published 2017 Sep 13. doi:10.7554/eLife.26278

Tsai NP, Huber KM. Protocadherins and the Social Brain. Biol Psychiatry. 2017;81(3):173‐174. doi:10.1016/j.biopsych.2016.10.025

Tsai NP, Wilkerson JR, Guo W, Huber KM. FMRP-dependent Mdm2 dephosphorylation is required for MEF2-induced synapse elimination. Hum Mol Genet. 2017;26(2):293‐304. doi:10.1093/hmg/ddw386

Rajkovich KE, Loerwald KW, Hale CF, Hess CT, Gibson JR, Huber KM. Experience-Dependent and Differential Regulation of Local and Long-Range Excitatory Neocortical Circuits by Postsynaptic Mef2c. Neuron. 2017;93(1):48‐56. doi:10.1016/j.neuron.2016.11.022

2016

Guo W, Molinaro G, Collins KA, et al. Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice. J Neurosci. 2016;36(7):2131‐2147. doi:10.1523/JNEUROSCI.2921-15.2016

2015

Guo W, Ceolin L, Collins KA, Perroy J, Huber KM. Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model. Cell Rep. 2015;13(10):2297‐2311. doi:10.1016/j.celrep.2015.11.013

Loerwald KW, Patel AB, Huber KM, Gibson JR. Postsynaptic mGluR5 promotes evoked AMPAR-mediated synaptic transmission onto neocortical layer 2/3 pyramidal neurons during development. J Neurophysiol. 2015;113(3):786‐795. doi:10.1152/jn.00465.2014

2014

Wilkerson JR, Tsai NP, Maksimova MA, et al. A role for dendritic mGluR5-mediated local translation of Arc/Arg3.1 in MEF2-dependent synapse elimination. Cell Rep. 2014;7(5):1589‐1600. doi:10.1016/j.celrep.2014.04.035

Patel AB, Loerwald KW, Huber KM, Gibson JR. Postsynaptic FMRP promotes the pruning of cell-to-cell connections among pyramidal neurons in the L5A neocortical network. J Neurosci. 2014;34(9):3413‐3418. doi:10.1523/JNEUROSCI.2921-13.2014

2013

Jakkamsetti V, Tsai NP, Gross C, et al. Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depression. Neuron. 2013;80(1):72‐79. doi:10.1016/j.neuron.2013.07.020

2012

Tsai NP, Wilkerson JR, Guo W, et al. Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell. 2012;151(7):1581‐1594. doi:10.1016/j.cell.2012.11.040

Niere F, Wilkerson JR, Huber KM. Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression. J Neurosci. 2012;32(17):5924‐5936. doi:10.1523/JNEUROSCI.4650-11.2012

2011

Hays SA, Huber KM, Gibson JR. Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry. J Neurosci. 2011;31(40):14223‐14234. doi:10.1523/JNEUROSCI.3157-11.2011

2010

Pfeiffer BE, Zang T, Wilkerson JR, et al. Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2. Neuron. 2010;66(2):191‐197. doi:10.1016/j.neuron.2010.03.017

2008

Waung, M.W., Pfeiffer, B.E., Nosyreva, E.D., Ronesi, J.A. and Huber, K.M. (2008) Rapid translation of Arc/Arg3.1 selectively mediates mGluR dependent LTD through persistent increases in AMPAR endocytosis rate. Neuron, 59(1):84-97.

Gibson, J.R., Bartley, A.F., Hays, S. and Huber, K.M. (2008) An imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of Fragile X Syndrome. Journal of Neurophysiology, 100(5):2615-26.

Ronesi, J.A. and Huber, K.M. (2008) Homer interactions are necessary for mGluR-induced long-term depression and translational activation. Journal of Neuroscience, 28(2):543-7.

2007

Volk, L. J., Pfeiffer, B.E, Gibson, J.R. and Huber, K.M. (2007) Multiple Gq-coupled receptors converge upon a common protein synthesis- dependent LTD that is affected in Fragile X syndrome mental retardation. Journal of Neuroscience, 27(43):11624-34.

Pfeiffer, B.E. and Huber, K.M. (2007) Fragile X Mental Retardation Protein induces synapse loss through acute postsynaptic translational regulation. Journal of Neuroscience, 27(12):3120-30. Highlighted in Nature Reviews Neuroscience, May 2007.

2006

Gibson, J.R., Bartley, A. and Huber, K.M. (2006) A Role for the Subthreshold Currents ILeak and IH in the Homeostatic Control of Excitability in Neocortical Somatostatin-Positive Inhibitory Neurons Journal of Neurophysiology, 96(1):420-32.

Nosyreva E. N. and Huber K.M. (2006) Metabotropic glutamate receptor dependent long-term depression persists in the absence of protein synthesis in the mouse model of Fragile X Syndrome Journal of Neurophysiology, 95(5): 3291-5.

Volk, L, Daly, C.A. and Huber K.M. (2006) Differential roles for group 1 mGluR subtypes in induction and expression of chemically-induced hippocampal long-term depression. Journal of Neurophysiology, 95(4): 2427-38.

2005

Nosyreva, E.N. and Huber, K.M. (2005) Developmental switch in mechanisms of hippocampal metabotropic glutamate receptor dependent synaptic plasticity. Journal of Neuroscience, 25(11): 2992-3001.

2004

Gallagher, S.M.. Daly, C.A., Bear, M.F. and Huber, K.M. (2004) Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor -dependent long-term depression in hippocampal area CA1. Journal of Neuroscience, 24(20):4859-64.

2002

Huber, K.M., Gallagher, S., Warren, S.T. and Bear, M.F. (2002) Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc. Natl. Acad. Sci., 99(11): 7746-7750.

2000

Huber, K.M., Kayser, M.S. and M.F. Bear. (2000) Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent LTD. Science, 288(5469):1254-1257.

Complete list of Dr. Huber’s publications