Two postdoctoral positions are available for collaborative projects managed by Dr. Kimberly Huber and Dr. Jay Gibson in the Neuroscience Department at UT Southwestern Medical Center in Dallas. The overall goal of these projects is to understand synaptic and circuit mechanisms of neocortical development and function and the role of autism risk genes. These projects are funded for 4-5 years by 2 new NIH grants.
One position will be funded by a new NIH Collaborative Research Center in Fragile X Syndrome , which is a collaboration among 3 research teams working at different levels in both mice and humans to understand and treat neocortical circuit dysfunction and develop translational neurophysiological biomarkers for Fragile X. The project will test the role of specific inhibitory neuron types in regulation of cortical circuit dynamics in Fragile X Syndrome model mice using optogenetics, chemogenetics and electrophysiological methods. Through collaborations with the other research teams in the Center, we will examine how these mechanisms impact brain function at the systems in vivo and behavioral level in mice and possibly humans. The position would principally involve electrophysiological experiments in acutely prepared neocortical slices, incorporating optogenetics, laser-guided circuit mapping techniques and molecular manipulations of single cells in vivo, and possibly in vivo recording techniques.
A second position is funded by a new NIH R37 grant to study sex-specific mechanisms of neocortical dysfunction in the PTEN deletion model of autism. The project will also utilize electrophysiological methods as described above and will also incorporate biochemical methods to examine the interaction of sex hormones and autism-risk genes on cortical circuits, of which little is known.
Applicants should have a Ph.D. in neuroscience or related field. Experience in electrophysiology is preferred. To apply, send a CV, statement of interests, and a list of 3 references to email@example.com or firstname.lastname@example.org . For more information on our laboratory, go to these links: Kimberly Huber Lab - UT Southwestern and https://www.utsouthwestern.edu/labs/gibson/. More information on our postdoctoral training program and benefits can be found in our Postdoc Handbook or at http://www.utsouthwestern.edu/postdocs.
We want to welcome Christopher Williams, Huber Lab’s new skillful and reliable technician. Welcome Chris!
Congratulation to Dr. Gemma Molinaro on her publication in Molecular Autism Journal (collaboration with Dr. Joel Richter at U Massachusetts Medical School).
Hien A, Molinaro G, Liu B, Huber KM, Richter JD. Ribosome profiling in mouse hippocampus: plasticity-induced regulation and bidirectional control by TSC2 and FMRP. Mol Autism. 2020 Oct 14;11(1):78. doi: 10.1186/s13229-020-00384-9. PMID: 33054857; PMCID: PMC7556950.
Congratulations to Andrew Holley for receiving the grant from FRAXA Research Foundation for investigating circuit mechanisms for auditory system dysfunction and drug tolerance in the Fragile X mouse model.
Drs. Kimberly Huber and Jay Gibson are part of newly funded NIH Collaborative Research Center in Fragile X Syndrome. https://www.nichd.nih.gov/newsroom/news/093020-fragile-x
Dr. Kimberly Huber received a new NIH multiple PI grant with Dr. Joel Richter at U Massachusetts Medical School for research on FMRP regulation of gene expression.
We want to welcome Jacob Eli Bowles, Huber Lab’s new talented and highly motivated technician. Welcome Eli!
Congratulations to Dr. Kimberly Huber for receiving Javits Award 2020 for the project examining sex-specific mechanisms of cortical circuit dysfunction in a mouse ASD model.