Featured Publications

Cholesterol auxotrophy and intolerance to ezetimibe in mice with SREBP-2 deficiency in the intestine.

Rong S, McDonald J, Engelking L J. Lipid Res. 2017 Jun

Scap is required for sterol synthesis and crypt growth in intestinal mucosa.

McFarlane MR, Cantoria MJ, Linden AG, January BA, Liang G, Engelking LJ J. Lipid Res. 2015 Apr

Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.

Engelking LJ, Evers BM, Richardson JA, Goldstein JL, Brown MS, Liang G J. Clin. Invest. 2006 Sep 116 9 2356-65

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.

Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS J. Clin. Invest. 2005 Sep 115 9 2489-98

Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.

Engelking LJ, Kuriyama H, Hammer RE, Horton JD, Brown MS, Goldstein JL, Liang G J. Clin. Invest. 2004 Apr 113 8 1168-75

Interplay between ChREBP and SREBP-1c Coordinates Postprandial Glycolysis and Lipogenesis in Livers of Mice.

Linden AG, Li S, Choi HY, Fang F, Fukasawa M, Uyeda K, Hammer RE, Horton JD, Engelking LJ, Liang G J. Lipid Res. 2018 Jan

Developmental and extrahepatic physiological functions of SREBP pathway genes in mice.

Engelking LJ, Cantoria MJ, Xu Y, Liang G Semin. Cell Dev. Biol. 2017 Jul

Hypoxia-inducible factor-1a activates insig-2 transcription for degradation of HMG CoA reductase in the liver.

Hwang S, Nguyen AD, Jo Y, Engelking LJ, Brugarolas J, DeBose-Boyd RA J. Biol. Chem. 2017 Apr

Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine.

McFarlane MR, Liang G, Engelking LJ J. Biol. Chem. 2014 Jan 289 4 2148-56

Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes.

Engelking LJ, McFarlane MR, Li CK, Liang G J. Lipid Res. 2012 Jul 53 7 1359-68