The Aging Brain

Stress Response Signaling

Lipid Metabolism

Traumatic Brain Injury

Research in the Douglas Lab seeks to understand how stress response pathways alter cell physiology, and ultimately influence the aging process and human disease. We can harness latent stress response pathways and apply their protective properties to a multitude of disease models.

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News Updates

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Surveillance pathway tells cells when they run low on lipids
https://www.sciencedaily.com/releases/2022/05/220518152356.htm

Date: May 18, 2022

Source: UT Southwestern Medical Center

Summary: Researchers have discovered a molecular pathway that allows cells to sense when their lipid supplies become depleted, prompting a flurry of activity that prevents starvation. The findings might someday lead to new ways to combat metabolic disorders and a variety of other health conditions.

Research Highlights

Stress in Neurodegeneration

Stress in Neurodegeneration

We seek to understand how stress response pathways protect against neurodegenerative disorders.

High-Throughput Trauma enlargement

High-Throughput Trauma

We utilize the nematode C. elegans to screen for novel factors which mediate protection against blunt trauma.

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Lipid Surveillance

Our studies examine how imbalances in lipid homeostasis can deleteriously impact health and metabolism.

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The Aging Brain

Our studies examine how the aging process influences traumatic brain injury and neurodegeneration.

Meet the Principal Investigator

Peter Douglas, PhD

Peter Douglas, PhD

Dr. Douglas is a faculty member of the Hamon Center for Regenerative Science and Medicine (CRSM) in the Department of Molecular Biology and an integral part of the Genetics, Development and Disease (GDD), and Neuroscience Graduate Programs at UT Southwestern.

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