Research Publication Highlights

General Topics

  • Nam, Y-J, Song, K, Luo, X, Daniel, E, Lambeth, K, West, KA, Hill, JA, DiMaio, JM, Baker, LA, Bassel-Duby, R, Olson, EN. Reprogramming of adult human fibroblasts toward a cardiac fate. Proceedings of the National Academy of Science, 110(14):5588-93, 2013. PMID: 23487791.
  • Chang, S-W, Mislankar, M, Misra, C, Huang, N, DaJusta, DG, Harrison, SM, McBride, KL, Baker, LA, and Garg, V. Genetic abnormalities in FOXP1 are associated with congenital heart defects. Human Mutation, 34(9):1226-30, 2013. PMID: 23766104.
  • Nagamani, S.C.S., Erez, A., Probst, F.J., Bader, P., Evans, P., Baker, L.A., Fang, P., Bertin, T., Stankiewicz, P., Nelson, D., Patel, A., and Cheung, S.W. Small genomic rearrangements involving FMR1 support the importance of its gene dosage for normal neurocognitive function. Neurogenetics, 13(4):333-9, 2012. PMID: 22890812
  • Cowan, C.A., Yokoyama, N., Saxena, A., Chumley, M.J., Silvany, R.S., Baker, L.A., Srivastava, D., and Henkemeyer, M. Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development. Dev Biol, 271(2):263-71, 2004. PMID: 15223333.
  • Flickinger, C.J., Howards, S.S., Skaggs, L.A., Baker, L.A., Herr, J.C.: Antisperm autoantibody responses to vasectomy and vasovasostomy in Fischer and Lewis rats. J Reprod Immunol 28:137-157, 1995. PMID: 7769580.
  • Flickinger, C.J., Howards, S.S., Bush, L.A., Baker, L.A., Herr, J.C.: Temporal recognition of sperm autoantigens by IgM and IgG autoantibodies after vasectomy and vasovasostomy. J Reprod Immunol 27:135-150, 1994. PMID: 7884742.

Prune Belly Syndrome

  • Granberg, C.F.*, Harrison,S.M.*,Dajusta, D., Zhang, S., Hajarnis, S., Igarashi, P., and Baker, L.A. (*Co-first authors) Genetic Basis of Prune Belly Syndrome: Screening the HNF1bgene, J Urol, 187: 272-278, 2012. PMID: 22114815.

Disorders of Sexual Development

  • Harrison, SM., Granberg, CF, Keays, M., Grimsby, GM, Baker, LA. DNA Copy-number variations in 46,XY disorders of sex development. J Urol, S0022-5347(14)03793-8, 2014.
  • Harrison, SM, Seideman, C, and Baker, LA. DNA Copy-Number Variations in Persistent Cloaca Patients. J Urol, 191(5 Suppl):1543-6, 2014.
  • Harrison, SM, Campbell, IM, Keays, M, Granberg, CF, Villanueva, C, Tannin, G, Cope-Yokoyama, S., Zinn, AR, Castrillon DH, Shaw, CA, Stankiewicz, P, and Baker, LA. Screening and Familial Characterization of Copy-Number Variations in NR5A1 in 46,XY Disorders of Sexual Development and Premature Ovarian Failure. Am J Med Genet Pt A, 161(10):2487-94, 2013. PMID: 23918653.

VACTERL Association

  • Prieto, J.C., Garcia, N.M., Elder F.F., Zinn A.R., Baker, L.A. Phenotypic Expansion of the Supernumerary Derivative (22) Chromosome Syndrome. J Peds Surg, 41(11): 1928-32, 2007. PMID: 18022449.

Cryptorchidism/Testicular Torsion

  • Sozubir, S., Barber, T., Wang, Y., Ahn, C. Zhang, S., Verma, S., Lonergan, D., Lorenzo, A.J., Nef, S., and Baker, L.A. Loss of Insl3: A potential predisposing factor for testicular torsion. J Urol, 183(6):2373-9, 2010. PMID: 20400152.
  • Nguyen, M.T., Showalter, P., Timmons, C.F., Nef, S., Parada, L.F., and Baker, L.A. Effects of Orchiopexy on Congenitally Cryptorchid Insulin-3 Knockout Mice. J Urol, 168:1779-83, 2002. PMID: 12352358.
  • Baker, L.A., Zhang, S., Nef, S., Nguyen, M., Pohl, H., and Parada, L.F. The Insulin-3 (INSL3) Gene: Lack of a genetic basis for human cryptorchidism. J Urol, 167(6): 2534-7, 2002. PMID: 11992081.
  • Baker, L.A., Turner, T.T.: Leydig cell function after experimental testicular torsion despite loss of spermatogenesis. J Androl 16:12-17, 1995. PMID: 7768748.

Lower GU Tract Anomalies of Cloaca, Imperforate Anus, and Hypospadias

  • Bhoj, E.J., Ramos, P., Baker, L.A., Cost, N.G., Nordenskjöld, A., Elder, F.F., Bleyl, S.B., Bowles, N.E., Maitra, M., Garg, V., Delhomme, B., Vanhoutteghem, A., Djian, P., and Zinn, A.R. Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development. Eur J Hum Genet, 19:540-6, 2011. PMID: 21368915.
  • De Leeuw, N., Bulk, S., Green, A., Jaekle-Santos, L., Baker, L.A., Zinn, A.R., Kleefstra, T., van der Snagt, J., Morgante, A.M.V., de Vries, B.B.A., van Bokhoven, H., and de Brouwer, A.P.M.: UBE2A Deficiency Syndrome: Moderate to Severe Intellectual Disability Accompanied by Seizures, Absent Speech and Urogenital Anomalies in Male Patients. Am J Med Genet - A, 152A(12): 3084-90, 2010. PMID: 21108393.
  • Yucel, S., Dravis, C., Garcia, N., Henkemeyer, M., and Baker, L.A. Hypospadias and anorectal malformations mediated by Eph/ephrin signaling. J Peds Urol, 3:354-363, 2007. PMID: 18431460.
  • Jenkins, D., Bitner-Glindzicz, M., Thomasson, L., Malcolm, S., Warne, S. A., Feather, S. A., Falnagan, S. E., Ellard, S., Bingham, C., Santos, L., Henkemeyer, M., Zinn, A., Baker, L. A., Wilcox, D.T., and Woolf, A. Mutation analyses of UPIIIA, SHH, EFNB2 and HNF1β in persistent cloaca and associated kidney malformations. J Peds Urol, 3(1):2-9, 2007. PMID: 17476318.
  • Garcia, N.M., Allgood, J., Santos, L.J., Lonergan, D., Batanian, J.R., Henkemeyer, M., Bartsch, O., Schultz, R.A., Zinn, A.R., and Baker, L.A. Deletion Mapping of Critical Region for Hypospadias, Penoscrotal Transposition and Imperforate Anus on Human Chromosome 13. J Peds Urol, 2(4):233-242, 2006. PMID: 17476316.
  • Yucel, S., Henkemeyer, M., Garcia, N., and Baker, L.A. Eph/ephrin signaling in hypospadias and anorectal malformations. Proceedings of the First World Congress on Hypospadias and Intersex Disorders, pp. 51-66, 2006.
  • Dravis, C., Yokoyama, N., Chumley, M.J., Cowan, C.A., Silvany, R.S., Shay, J., Baker, L.A. and Henkemeyer, M. Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development. Dev Biol, 271(2):272-90, 2004. July 15 Issue Cover Photograph. PMID: 15223334.
  • Lorenzo, A.J., Nguyen, M.T., Sozubir, S., Henkemeyer, M., and Baker, L.A. Dihydrotestosterone induction of EphB2 expression in the female genital tubercle mimics male pattern of expression during embryogenesis. J Urol, 170:1618-23; discussion 1623, 2003. PMID: 14501676.
  • Baker, L.A., Gomez, R.A.: TMP21-1, a vesicular trafficking protein, is differently expressed during induction of ureter and metanephros. J Urol 164:562-566, 2000. PMID: 10893644.
  • Baker. L.A., Gomez, R.A.: Embryonic development of the ureter and bladder: Acquisition of smooth muscle. J Urol 160:545-550, 1998. PMID: 9679926.