Biological Chemistry Faculty

Chair:  Kristen Lynch 

Stefan Andersson -- Steroid hormone action and metabolism; biochemistry, pharmacology, and genetics of 17b-hydroxysteroid dehydrogenases.

Richard Auchus -- Biochemical, structural, and genetic studies of the enzymes and pathways of steroid hormone biosynthesis in human beings.

Michael Brown -- Regulation of gene expression; cell-surface receptor function; genetics and biochemistry of lipoprotein and cholesterol metabolism.

Richard Bruick -- Regulation of the mammalian hypoxic response pathway.

Igor Butovich -- 

Chuo Chen -- Naturalproduct synthesis, synthetic methodology development, small molecule library synthesis and chemical biology.

David Chuang  -- Structure and function of macromolecular machines; mechanism of chaperone-mediated protein folding.

Nicholas Conrad -- gene expression and RNA biogenesis in Kaposi's sarcoma-associated herpesvirus.

David Corey -- Engineering proteins and nucleic acids for novel function.

Russell DeBose-Boyd  -- Regulation of HMG-CoA reductase and sterol metabolism.

Jef De Brabander -- Synthesis of natural products and other molecular architectures and interrogation of their mode-of-action using molecular pharmacology and biochemistry.

George DeMartino -- Biochemical mechanisms and regulation of intracellular protein degradation; structure and function of intracellular proteases.

Victoria Esser  -- Molecular biology of carnitine palmitoyltransferase; tissue-specific knockout mouse of muscle CPT I.

Douglas Frantz -- Development and discovery of practical and efficient synthetic methodologies for useful application in both medicinal and process chemistry activities in support of drug discovery and pre-clinical development of drug candidates.

Kevin H. Gardner -- Biophysical and biochemical studies of photoreceptors and other signaling proteins.

Jinming Gao-- Cancer nanomedicine; targeted drug delivery; cancer molecular imaging.

Marie-Alda Gilles-Gonzalez -- Mechanisms of O2, CO and NO sensing and in novel signal-transduction heme proteins.

Elizabeth Goldsmith -- Crystallographic studies of recognition and signal transduction in protein molecules.

Joseph Goldstein -- Genetics and biochemistry of lipoprotein and cholesterol metabolism; cell-surface receptor function; regulation of gene expression.

Bethany Janowski -- Gene regulation by small RNAs

Thomas Kodadek -- Biochemistry of transcriptional regulation, chemical biology, proteomics.

Jennifer Kohler -- understanding and exploiting the molecular foundations of glycoconjugate biosynthesis

Mark Lehrman -- Informational carbohydrates in the endoplasmic reticulum:  roles in protein folding, stress responses and human disease.

Wen-Hong Li -- Intercellular communications through gap junctions; molecular engineering of fluorescent sensors for cellular imaging; wide field, confocal and multi-photon fluorescence microscopy; mechanisms and functions of cellular calcium signaling.

Qinghua Liu -- Cellular use of small RNAs to specifically silence gene expression; harnessing the power of RNAi to shut down expression of pathological genes to cure human disease.

Kristen Lynch -- Mechanisms and regulation of mammalian pre-mRNA splicing.

Mischa Machius -- Basic processes in living organisms at atomic level, using X-ray crystallography, NMR spectroscopy and other biophysical techniques.

John MacMillan -- Isolation and structural determination of biologically active natural products from marine bacteria; new methodology for stereochemical assignment; medicinal chemistry.

Steven McKnight -- Molecular genetics and biochemical studies of mammalian gene regulation.

Carole Mendelson  -- Molecular mechanisms in tissue-specific, developmental and hormonal regulation of eukaryotic gene expression.

Marc Mumby -- Signaling pathways controlling cell growth and transformation.

Kim Orth -- Signal transduction in the microbial pathogen Yersinia pestis.

Steve Patrie --role of post-translational modifications (PTMs) in disease biology, and development of protein array and mass spectrometry technologies for discovery of novel PTMs and clinical diagnostics.

Margaret Phillips -- Polyamine and pyrimidine metabolism in trypanosome and malaria parasites.

Rama Ranganathan -- Biophysical mechanisms that underlie cellular signal transduction in sensory neurons.

Joseph Ready -- Discovery and application of new chemical reactions; total synthesis of complex molecules.

Michael Rosen -- Analysis of structural, biochemical, and cell biological mechanisms that regulate the actin cytoskeleton.

Vanessa Sperandio -- Quorum sensing in enteropathogenic Escherichia coli

Diana Tomchick -- Structural characterization of signal-transduction protein complexes, proteins involved in reproductive biology and novel proteins from pathogenic bacteria; improved methods of crystallographic data collection, processing and phasing; automated crystallization techniques.

Benjamin Tu -- metabolic oscillation and the mechanisms by which cellular processes are coupled to cyclic changes in metabolic or redox state in time

Kosaku Uyeda -- Elucidation of biochemical mechanisms for regulation of carbohydrate metabolism in mammalian cells.

Xiaodong Wang -- Biochemistry of mammalian apoptosis, chemical synthesis of inhibitors of apoptosis.

Wade Winkler -- RNA biology; biochemistry of gene regulation; RNA structure and function; posttranscriptional genetic control; microbial metabolism.

Jin Ye -- Geranylgeranylation and HCV replication; regulation of geranylgeranyl lipid homeostasis; regulated intramembrane proteolysis.