Scott MM, Lachey JL, Sternson SM, Lee CE, Elias CF, Friedman JM, Elmquist JK.
Leptin Targets in the Mouse Brain. J Comp Neurol. 2009 Jun 19;514(5):518-32.
Williams KW, Scott MM, Elmquist JK. From Observation to Experimentation:
Leptin Action in the Mediobasal Hypothalamus. Am J Clin Nutr. 2009 Mar;89(3):985S-990S.
Fukuda M, Jones JE, Olson D, Hill J, Lee CE, Gautron L, Choi M, Zigman JM, Lowell BB, Elmquist JK.
Monitoring FoxO1 Localization in Chemically Identified Neurons. J Neurosci. 2008 Dec 10; 28(50):13640-8.
Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK.
5-HT2CRs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis. Neuron. 2008 Nov 26;60(4):582-9.
Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK.
Acute Effects of Leptin Require PI3K Signaling in Hypothatalmic Proopiomelanocortin Neurons in Mice. J Clin Invest. 2008 May;118(5):1796-805.
Williams KW, Coppari R, Elmquist JK.
"AMPing Up" our Understanding of the Hypothalamic Control of Energy Balance. J Clin Invest. 2007 Aug;117(8):2089-92.
Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA.
Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake. Neuron. 2006 Jul 20;51(2):239-249.
Scott MM, Marcus JN, Elmquist JK.
Orexin neurons and the TASK of glucosensing. Neuron. 2006 Jun 1;50(5):665-7. Review.
Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S Jr, Elmquist JK, Lowell BB.
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 2006 Jan 19;49(2):191-203.
Zigman JM, Nakano Y, Coppari R, Balthasar N, Marcus JN, Lee CE, Jones JE, Deysher AE, Waxman AR, White RD, Williams TD, Lachey JL, Seeley RJ, Lowell BB, Elmquist JK.
Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest. 2005 Dec;115(12):3564-72.
de Luca C, Kowalski TJ, Zhang Y, Elmquist JK, Lee C, Kilimann MW, Ludwig T, Liu SM, Chua SC Jr.
Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest. 2005 Dec;115(12):3484-93. Epub 2005 Nov 10.
Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB.
Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell. 2005 Nov 4;123(3):493-505.
Coppari R, Ichinose M, Lee CE, Pullen AE, Kenny CD, McGovern RA, Tang V, Liu SM, Ludwig T, Chua SC Jr, Lowell BB, Elmquist JK.
The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab. 2005 Jan;1(1):63-72.
Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC Jr, Elmquist JK, Lowell BB.
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron. 2004 Jun 24;42(6):983-91.
Zigman JM, Elmquist JK. From anorexia to obesity--the yin and yang of body weight control. Endocrinology 2003; 144:3749-3756.
Elmquist JK, Marcus JN Rethinking the central causes of diabetes. Nature Medicine 2003; 9:645-647.
Liu H, Kishi T, Roseberry AG, Cai X, Lee CE, Montez J, Friedman JM, Elmquist JK. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J. Neuroscience 2003; 23:7143-7154.
Zhang YH, Lu J, Elmquist JK, Saper CB.Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and fos expression in rat brain. J. Comp. Neurol. 2003; 463:3-12.
Willie JT, Chemelli RM, Sinton CM, Tokita S, Williams SC, Kisanuki YY, Marcus JN, Lee C, Elmquist JK, Kohlmeier KA, Leonard CS, Richardson JA, Hammer RE, Yanagisawa M.Distinct narcolepsy syndromes in orexin receptor type 2 (OX2R) and orexin knockout mice: molecular genetic dissection of non-REM and REM Sleep regulatory processes. Neuron 2003; 38:715-730.
Heisler LK, Cowley MA, Kishi T, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Zigman JM, Cone RD, Elmquist JK. Central serotonin and melanocortin pathways regulating energy homeostasis. Ann. N. Y. Acad. Sci. 2003; 994:169-174.
Masuzaki H, Yamamoto H, Kenyon CJ, Elmquist JK, Morton NM, Paterson JM, Shinyama H, Sharp MG, Fleming S, Mullins JJ, Seckl JR, Flier JS. Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J. Clinical Investigation 2003; 112:83-90.
Kishi T, Aschkenasi CJ, Lee CE, Mountjoy KG, Saper CB, Elmquist JK. Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J. Comp. Neurol. 2003; 457:213-235.
Yamamoto H, Kishi T, Lee CE, Choi BJ, Fang H, Hollenberg AN, Drucker DJ, Elmquist JK. Glucagon-like peptide-1 responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 action with central autonomic control sites. J. Neuroscience 2003; 23:2939-2946.
Saper CB, Chou TC, Elmquist JK. The need to feed: homeostatic and hedonic control of eating. Neuron 2002; 36:199-211.
Heisler LK, Cowley MA, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Marcus JN, Holstege H, Lee CE, Cone RD, Elmquist JK. Activation of central melanocortin pathways by fenfluramine. Science. 2002. 297:609-611.
Yamamoto H, Lee CE, Marcus JN, Williams TD, Overton JM, Lopez ME, Hollenberg AN, Baggio L, Saper CB, Drucker DJ, Elmquist JK. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J Clin Invest. 2002 110:43-52.
Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad A, Haj F, Wang Y, Minokoshi Y, Kim YB, Elmquist JK, Tartaglia LA, Kahn BB, Neel BG. 2002. PTP1B regulates leptin signal transduction in vivo. Dev Cell. 2002 2:489-495.
Hahm S, Fekete C, Mizuno TM, Windsor J, Yan H, Boozer CN, Lee C, Elmquist JK, Lechan RM, Mobbs CV, Salton SR. VGF is required for obesity induced by diet, gold-thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. J. Neuroscience 2002; 22:6929-6938.
Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, Elmquist JK. Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 2001 Jun 18;435(1):6-25.
Elmquist, JK. Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin. Int. J. Obes. 2001; 5:S78-82.
Abel ED, Ahima RS, Boers ME, Elmquist JK, Wondisford FE. Critical role for thyroid hormone receptor beta2 in the regulation of paraventricular thyrotropin-releasing hormone neurons. J Clin Invest 2001. 107:1017-1023.
Dumont LM, Wu CS, Aschkenasi CJ, Elmquist JK, Lowell BB, Mountjoy KG. Mouse melanocortin-4 receptor gene 5'-flanking region imparts cell specific expression in vitro. Mol Cell Endocrinol 2001. 184:173-185.
Chou TC, Lee CE, Lu J, Elmquist JK, Hara J, Willie JT, Beuckmann CT, Chemelli RM, Sakurai T, Yanagisawa M, Saper CB, Scammell TE. Orexin (hypocretin) neurons contain dynorphin. J Neurosci 2001. 21:RC168.
Malick A, Jakubowski M, Elmquist JK, Saper CB, Burstein R. A neurohistochemical blueprint for pain-induced loss of appetite. Proc Natl Acad Sci U S A. 2001. 98:9930-9935..
Hashimoto K, Curty FH, Borges PP, Lee CE, Abel ED, Elmquist JK, Cohen RN, Wondisford FE. An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proc Natl Acad Sci U S A 2001. 98:3998-4003.
Lu J, Zhang YH, Chou TC, Gaus SE, Elmquist JK, Shiromani P, Saper CB. Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation. J Neurosci 2001. 21:4864-4874.
Elias CF, Lee CE, Kelly JF, Ahima RS, Kuhar M, Saper CB, Elmquist JK. Distribution and characterization of CART neurons in the rat and human hypothalamus. J Comp Neurol. 2001 Mar 26;432(1):1-19.
Harris M, Aschkenasi C, Elias CF, Chandrankunnel A, Nillni EA, Bjorbaek C, Elmquist JK, Flier JS, Hollenberg AN. Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest. 2001 Jan 1;107(1):111-120.
Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Elmquist J, Lowell B, Flier JS, Maratos-Flier E. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J Clin Invest 2001; 107:379-86.
Elias CF, Kelly JF, Lee CE, Ahima RS, Drucker DJ, Saper CB, Elmquist JK. Chemical characterization of leptin-activated neurons in the rat brain. J Comp Neurol. 2000 Jul 24;423(2):261-81.
Zhang YH, Lu J, Elmquist JK, Saper CB. Lipopolysaccharide activates specific populations of hypothalamic and brainstem neurons that project to the spinal cord. J Neurosci. 2000 Sep 1;20(17):6578-86.
Ahima RS, Saper CB, Flier JS, Elmquist JK. Leptin regulation of neuroendocrine systems. Front Neuroendocrinol. 2000 Jul;21(3):263-307. Review.
Oka T, Oka K, Scammell TE, Lee C, Kelly JF, Nantel F, Elmquist JK, Saper CB. Relationship of EP(1-4) prostaglandin receptors with rat hypothalamic cell groups involved in lipopolysaccharide fever responses. J Comp Neurol. 2000 Dec 4;428(1):20-32.
Kelly JF, Elias CF, Ahima RS, Bjørbæk C, Saper CB, Flier JS, Elmquist JK. Differential induction of immediate early gene expression in the central nervous system by ciliary neurotrophic factor and leptin. Diabetes 2003.
Elmquist JK. Anatomic basis of leptin action in the hypothalamus. Front Horm Res. 2000;26:21-41. Review.
Silveira DC, Klein P, Ransil BJ, Liu Z Hori A, Holmes GL, de LaCalle S, Elmquist JK, Herzog AG. Lateral asymmetry in activation of hypothalamic neurons with unilateral amygdaloid seizures. Epilepsia 2000; 41:34-41.
Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron. 1999 Aug;23(4):775-86.
Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999 Aug 20;98(4):437-51.
Ahima RS, Kelly J, Elmquist JK, Flier JS. Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia. Endocrinology. 1999 Nov;140(11):4923-31.
Elmquist JK, Elias CF, Saper CB. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron. 1999 Feb;22(2):221-32. Review.
Bjorbaek C, Elmquist JK, El-Haschimi K, Kelly J, Ahima RS, Hileman S, Flier JS. Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor. Endocrinology. 1999 May;140(5):2035-43.
Swanson JJ, Kuehl-Kovarik MC, Elmquist JK, Sakaguchi DS, Jacobson CD. Development of the facial and hypoglossal motor nuclei in the neonatal Brazilian opossum brain. Brain Res Dev Brain Res. 1999 Feb 5;112(2):159-72.
Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, Couceyro PR, Kuhar MJ, Saper CB, Elmquist JK. Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron. 1998 Dec;21(6):1375-85.
Elias CF, Saper CB, Maratos-Flier E, Tritos NA, Lee C, Kelly J, Tatro JB, Hoffman GE, Ollmann MM, Barsh GS, Sakurai T, Yanagisawa M, Elmquist JK. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol. 1998 Dec 28;402(4):442-59.
Elmquist JK, Maratos-Flier E, Saper CB, Flier JS. Unraveling the central nervous system pathways underlying responses to leptin. Nat Neurosci. 1998 Oct;1(6):445-50. Review.
Elmquist JK, Ahima RS, Elias CF, Flier JS, Saper CB. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):741-6.
Elmquist JK, Bjorbaek C, Ahima RS, Flier JS, Saper CB. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol. 1998 Jun 15;395(4):535-47.
Bjorbaek C, Elmquist JK, Frantz JD, Shoelson SE, Flier JS. Identification of SOCS-3 as a potential mediator of central leptin resistance. Molecular Cell 1998; 1:619-625.
Bjorbaek C, Elmquist JK, Michl P, Ahima RS, van Bueren A, McCall AL, Flier JS. Expression of leptin receptor isoforms in rat brain microvessels. Endocrinology. 1998 Aug;139(8):3485-91.
Tritos NA, Elmquist JK, Mastaitis JW, Flier JS, Maratos-Flier E. Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice. Endocrinology. 1998 Nov;139(11):4634-41.
Scammell TE, Griffin JD, Elmquist JK, Saper CB. Microinjection of a cyclooxygenase inhibitor into the anteroventral preoptic region attenuates LPS fever. Am J Physiol. 1998 Mar;274(3 Pt 2):R783-9.
Sherin JE, Elmquist JK, Torrealba F, Saper CB. Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat. J Neurosci. 1998 Jun 15;18(12):4705-21.
Elmquist JK, Scammell TE, Saper CB. Mechanisms of CNS response to systemic immune challenge: the febrile response. Trends Neurosci. 1997 Dec;20(12):565-70. Review.
Elmquist JK. CNS regulation of energy balance and body weight: insights from rodent models. Lab Anim Sci. 1998 Dec;48(6):630-7. Review.
Elmquist JK, Ahima RS, Maratos-Flier E, Flier JS, Saper CB. Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology. 1997 Feb;138(2):839-42.
Saper CB, Sherin JE, Elmquist JK. Role of the ventrolateral preoptic area in sleep induction. In: Sleep and Sleep Disorders: From Molecules to Man. Hayaishi O, Inoue S, eds. Academic Press 1997, Tokyo, pp. 281-294.
Elmquist JK, Breder CD, Sherin JE, Scammell TE, Hickey WF, Dewitt D, Saper CB. Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages. J Comp Neurol. 1997 May 5;381(2):119-29.
Elmquist JK, Scammell TE, Saper CB. CNS Responses to immune system challenge: mechanisms of the febrile response. Trends in Neurosci. 1997; 20:565-570.
Flier JS, Elmquist JK. Energetic pursuit of leptin function. Nat Biotechnol. 1997 Jan;15(1):20-1.
Elmquist JK, Scammell TE, Jacobson CD, Saper CB. Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration. J Comp Neurol. 1996 Jul 15;371(1):85-103.
Elmquist JK, Saper CB. Activation of neurons projecting to the paraventricular hypothalamic nucleus by intravenous lipopolysaccharide. J Comp Neurol. 1996 Oct 21;374(3):315-31.
Scammell TE, Elmquist JK, Saper CB. Inhibition of nitric oxide synthase produces hypothermia and depresses lipopolysaccharide fever. Am J Physiol. 1996 Aug;271(2 Pt 2):R333-8.
Scammell TE, Elmquist JK, Griffin JD, Saper CB. Ventromedial preoptic prostaglandin E2 activates fever-producing autonomic pathways. J Neurosci. 1996 Oct 1;16(19):6246-54.
Swanson JJ, Kuehl-Kovarik MC, Czernik AJ, Wilson MC, Elmquist JK, Ross LR, Jacobson CD. Characterization and ontogeny of synapse-associated proteins in the developing facial motor nucleus of the Brazilian opossum. J. Comp. Neurol. 1996; 368:270-284.
Greenlee MH, Swanson JJ, Simon JJ, Elmquist JK, Jacobson CD, Sakaguchi DS. Postnatal development and the differential expression of presynaptic terminal-associated proteins in the developing retina of the Brazilian opossum, Monodelphis domestica. Brain Res Dev Brain Res. 1996 Oct 23;96(1-2):159-72.
Ackermann MR, Stabel JR, Pettit RK, Jacobson CD, Elmquist JK, Register KB, Rimler RB, Hilton JH. Reduced physeal area and chondrocyte proliferation in Pasteurella multocida toxin-treated rats. Vet. Path. 1995; 32:674-682.
Iqbal J, Elmquist JK, Ross LR, Ackermann MR, Jacobson CD. Postnatal neurogenesis of the hypothalamic paraventricular and supraoptic nuclei in the Brazilian opossum brain. Dev. Brain Research 1995; 85:151-160.
Elmquist JK, Swanson JJ, Sakaguchi DS, Ross LR, Jacobson CD. Developmental Distribution of GFAP and Vimentin in the Brazilian Opossum Brain. J. Comp. Neurol. 1994; 344:283-296.
Elmquist JK, Ackermann MR, Register KB, Rimler RB, Ross LR, Jacobson CD. Induction of fos-like immunoreactivity in the rat brain following Pasteurella multocida endotoxin administration. Endocrinology 1993; 133 (No. 6):3054-3057.
Elmquist JK, Ross LR, Hsu WH, Rothschild MF, Jacobson CD. Cholecystokinin immunoreactivity in the brains of young Meishan and Duroc pigs. J. Animal Breeding and Genetics 1993; 110:473-479.
Elmquist JK, Kao A, Kuehl-Kovarik MC, Jacobson CD. Developmental profile of galanin binding sites in the mammalian brain. Mol. Cell. Neurosci. 1993; 4:354-365.
Kuehl-Kovarik MC, Ross LR, Elmquist JK, Jacobson CD. Localization of cholecystokinin binding in the adult and developing Brazilian opossum brain. J. Comp. Neurol. 1993; 336:40-52.
Elmquist JK, Fox CA, Ross LR, Jacobson CD. Galanin-like immunoreactivity in the adult and developing Brazilian opossum brain. Dev. Brain Research 67:161-179.
