Joseph (Xin Jin) Zhou, M.D.
Professor of Pathology and Internal Medicine

Research Interests:

	Tissue expression of endothelial nitric oxide synthase (eNOS) in the kidneys of 63-week-old Wistar-Kyoto rats (WKY, A), untreated spontaneously hypertensive rats (SHR, B), and losartan-treated SHR (SHR-L, C).

My research has been focused on the regulation of L-arginine-nitric oxide pathway and the interplay of nitric oxide with reactive oxygen species in the pathogenesis of acquired and genetic hypertension as well as various other renal diseases in experimental animals.

Selected Publications:

Zhou, X.J., Z. Laszik, Z. Ni, X.Q. Wang, D.J. Brackett, M.R. Lerner, F.G. Silva, and N.D. Vaziri: Down-regulation of renal endothelial nitric oxide synthase expression in experimental glomerular thrombotic microangiopathy. Lab Invest. 80:1079-1087, 2000.

Zhou, X.J., Z. Laszik, X.Q. Wang, F.G. Silva, and N.D. Vaziri: Association of renal injury with increased oxygen free radical activity and altered nitric oxide metabolism in chronic experimental hemosiderosis. Lab Invest. 80:1905-1914, 2000.

Zhou, X.J., N.D. Vaziri, X.Q. Wang, F.G. Silva, and Z. Laszik: Nitric oxide synthase expression in hypertension induced by inhibition of glutathione synthase. J Pharmacol Exp Ther. 300:762-767, 2002.

Zhou, X.J., N.D. Vaziri, J. Zhang, H.W. Wang, and X.Q. Wang: Association of renal injury with nitric oxide deficiency in aged SHR: prevention by hypertension control with AT1 blockade. Kidney Int. 62:914-921, 2002.

Xie, C., X.J. Zhou, X. Liu, and C. Mohan: Enhanced susceptibility to end-organ disease in the lupus-facilitating NZW mouse strain. Arthritis Rheum. 48:1080-1092, 2003. (featured on cover page)

Liang, Z., C. Xie, C. Chen, D. Kreska, K. Hsu, L. Li, X.J. Zhou, and C. Mohan: Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus mice. J Exp Med. 199:381-398, 2004.

Xie, C., R. Sharma, H. Wang, X.J. Zhou, and C. Mohan: Strain distribution pattern of susceptibility to immune-mediated nephritis. J Immunol. 172:5047-5055, 2004.

Subramanian, S., Y.S. Yim, K. Liu, K. Tus, X.J. Zhou, and E.K. Wakeland: Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb. J Immunol. 175:1062-1072, 2005.

Fu, Y., C. Xie, J. Chen, J. Zhu, H. Zhou, J. Thomas, X.J. Zhou, and C. Mohan: Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production. J Immunol. 176:632-639, 2006.

Subramanian, S., K. Tus, Q.Z. Li, A. Wang, X.H. Tian, J. Zhou, C. Liang, G. Bartov, L.D. McDaniel, X.J. Zhou, R.A. Schultz, and E.K. Wakeland: A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci U S A. 103:9970-9975, 2006.